Maternal serum and amniotic fluid bisphenol A concentrations in the early second trimester

Yamada, Hideto; Furuta, Itsuko; Kato, Emi H.; Kataoka, Soromon; Usuki, Yasuteru; Kobashi, Gén; Sata, Fumihiro; Kishi, Reiko; Fujimoto, Seiichiro

doi:10.1016/s0890-6238(02)00051-5

Cited by 221 publications

(120 citation statements)

References 16 publications

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“…Because of concerns that BPA alters the development of rodents exposed during gestation, several human biomonitoring studies have focused on measuring BPA in serum from pregnant women, and in plasma, serum, and tissue from umbilical cords (Ikezuki et al 2002;Kuroda et al 2003;Lee et al 2008;Padmanabhan et al 2008;Schönfelder et al 2002;Tan and Ali Mohd 2003;Todaka and Mori 2002;Yamada et al 2002) (Tables 4 and 5). Of the eight studies examining these populations, six used analytical chemistry and two used ELISA.…”

Section: Healthymentioning

confidence: 99%

“…For instance, BPA levels in blood have been associated with a variety of conditions in women, including obesity, endometrial hyperplasia, endometriosis, recurrent miscarriages, sterility, and PCOS (reviewed by Vandenberg et al 2007). Other studies detected associations between high BPA exposure and chromosomal abnormalities, including pregnancies with fetuses that had an abnormal karyotype (Yamada et al 2002), recurrent miscarriage (Sugiura-Ogasawara et al 2005), and sister chromatid exchange measured in peripheral lymphocytes (Yang et al 2006). These epidemiological studies have several limitations, including small sample sizes, insufficient information on subject selection criteria, and crosssectional designs that failed to adequately control for potential confounders (Vandenberg et al 2007), thus preventing accurate assessments regarding the potential health risks of BPA.…”

Section: Relationships Between Measured Bpa Concentrations and Diseasmentioning

confidence: 99%

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Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A

Vandenberg

Chahoud

Heindel³

et al. 2012

Ciênc. saúde coletiva

333

331

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Estudos de biomonitoração do sistema urinário, circulatório e tecidos indicam grande exposição ao Bisfenol A Resumo Bisfenol A (BPA) é um dos produtos quí-micos mais produzido em todo o mundo, e a exposição humana a ele é considerada onipresente. Assim, há preocupações de que a quantidade de BPA para o qual os seres humanos estão expostos podem causar efeitos adversos à saúde. Nós examinamos muitas possibilidades sobre o porquê estudos de biomonitorização e toxicocinética podem chegar a conclusões aparentemente conflitantes. Mais de 80 estudos publicados de biomonitorização humana que mediram a concentração de BPA em tecidos humanos, urina, sangue e outros fluidos, juntamente com dois estudos de toxicocinéti-ca do metabolismo humano BPA foram examinados. BPA não conjugado foi detectado no sangue (nonanogramas por mililitro gama), e BPA conjugado foi detectado na grande maioria das amostras de urina. Em contraste, estudos de toxico-cinética propuseram que os seres humanos não são internamente expostos ao BPA. Dados disponíveis de estudos de biomonitorização indicam que a população em geral está exposta ao BPA e em risco de exposição interna ao BPA não conjugado. Os dois estudos de toxicocinética, que sugeriram a exposição humana ao BPA é insignificante, têm deficiências significativas e estão diretamente refutados por outros estudos e, portanto não são confiáveis para fins de avaliação de risco. Palavras-chave Disruptor endócrino, Exposição humana, Modelo PBPK/PBTK, Gravidez, Avaliação de risco, Toxicocinética Abstract Bisphenol A (BPA) is one of the highest-volume chemicals produced worldwide, and human exposure to BPA is thought to be ubiquitous. Thus, there are concerns that the amount of BPA to which humans are exposed may cause adverse health effects. We examined many possibilities for why biomonitoring and toxicokinetic studies could come to seemingly conflicting conclusions. More than 80 published human biomonitoring studies that measured BPA concentrations in human tissues, urine, blood, and other fluids, along with two toxicokinetic studies of human BPA metabolism were examined. Unconjugated BPA was routinely detected in blood (in the nanograms per milliliter range), and conjugated BPA was routinely detected in the vast majority of urine samples (also in the nanograms per milliliter range). In stark contrast, toxicokinetic studies proposed that humans are not internally exposed to BPA. Available data from biomonitoring studies clearly indicate that the general population is exposed to BPA and is at risk from internal exposure to unconjugated BPA. The two toxicokinetic studies that suggested human BPA exposure is negligible have significant deficiencies, are directly contradicted by hypothesis-driven studies, and are therefore not reliable for risk assessment purposes.

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Section: Healthymentioning

confidence: 99%

Section: Relationships Between Measured Bpa Concentrations and Diseasmentioning

confidence: 99%

Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A

Vandenberg

Chahoud

Heindel³

et al. 2012

Ciênc. saúde coletiva

333

331

View full text Add to dashboard Cite

show abstract

“…Studies from industrialized nations such as Germany and Japan, suggest that measurable levels of BPA are found in maternal circulation. [27][28][29] Similar studies have not been undertaken with pregnant women in the United States. The only available information in the US population relates to urinary levels of BPA metabolites in the general population.…”

Section: Introductionmentioning

confidence: 99%

Maternal bisphenol-A levels at delivery: a looming problem?

et al. 2008

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Objective: The objective was to determine whether bisphenol-A (BPA) is found in maternal circulation of pregnant women in the US population and is related to gestational length and birth weight.Method: Circulating levels of BPA were quantified by high performance liquid chromatography-tandem mass spectrometry at delivery in 40 southeastern Michigan mothers and correlated with gestational length and birth weight of offspring.Result: Maternal levels of unconjugated BPA ranged between 0.5 and 22.3 ng ml À1 in southeastern Michigan mothers. There was no correlation between BPA concentrations and gestational length or birth weight of offspring.Conclusion: This is the first study to document measurable levels of BPA in maternal blood of the US population. Long-term follow-up studies of offspring are needed to validate or refute concerns over human fetal exposure to synthetic exogenous steroids.

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“…It was observed that several EDCs are able to pass through the placenta to the fetus. Many recent studies were devoted to the transmittance of EDC and assessing their content in the cord blood serum and maternal adipose tissue [13][14][15][16][17][18][19][20][21][22][23][24][25][26], showing that a fetus and once born an infant may be exposed to significantly high levels of EDC [27]. This can result in a decrease in fetal birth weight, premature birth, psychomotor retardation and altered cognitive function [28][29][30][31][32][33].…”

Section: Endocrine Disrupting Compoundsmentioning

confidence: 99%

Research trends on emerging environment pollutants – a review

Rykowska

Wasiak

2015

Open Chemistry

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Concern for the natural environment increasingly devotes more attention to growing potential hazards resulting from the release of various substances. Currently, one of the main problems associated with environmental pollution is the derivation of organic compounds from wastewater. Substances derived from sewage leaks into the environment in the form of a multicomponent mixtures often enhances the toxic effects caused by these compounds. While analyzing the reports in the literature of the last two decades it can be seen that substantial efforts are devoted to the determination of selected trace contaminants present in wastewater. Among the most marked there are endocrine disrupting compounds, residues of pharmaceuticals and personal care products, plastics and sunscreens. Recently, a new group of compounds joined the aforementioned contaminants, namely drugs, whose legality and availability is increasing every year. Exposure to these type of compounds, named in the literature as emerging contaminants (ECs), involves, among others, such effects as hormonal imbalance, reduction of the survivability of aquatic organisms and reproductive problems.This paper provides a review of the types of emerging organic groundwater contaminants (EGCs) which are beginning to be found in the natural environment in many countries all around the world.

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Maternal serum and amniotic fluid bisphenol A concentrations in the early second trimester

Cited by 221 publications

References 16 publications

Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A

Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A

Maternal bisphenol-A levels at delivery: a looming problem?

Research trends on emerging environment pollutants – a review

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