Maternal serum cytokine levels in pregnancies complicated with threatened preterm labour

Herrera-Muñoz, Alejandra; Fernández-Alonso, Ana M.; Fischer-Suárez, Natalia; Chedraui, Peter; Pérez‐López, Faustino R.

doi:10.1080/09513590.2017.1284786

Cited by 25 publications

(25 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study we also demonstrated that there were no significant differences between mothers experiencing a preterm labor and those with term labor regarding vital signs, uterine cervical length, vaginal culture and other factors. Our results were in line with a recent study, performed by Herrera-Munoz and colleagues [13] . There, they examine 61 preterm mothers and their measurements showed higher amount of IL-5, IL-6, IL-7, IL-8, IL-10and TNF-a and lower amounts of GMC-SF which is suggested to be a sign of immune failure to maintain the mechanisms acting against inflammation [13] .…”

Section: Serum Levels Preterm Groupsupporting

confidence: 94%

“…Our results were in line with a recent study, performed by Herrera-Munoz and colleagues [13] . There, they examine 61 preterm mothers and their measurements showed higher amount of IL-5, IL-6, IL-7, IL-8, IL-10and TNF-a and lower amounts of GMC-SF which is suggested to be a sign of immune failure to maintain the mechanisms acting against inflammation [13] . But our results indicated that IL-4, IL-5 and IL-13 were also elevated in preterm labor.…”

Section: Serum Levels Preterm Groupsupporting

confidence: 94%

“…Elevated IL-8 was in line with our findings while as mentioned earlier; we found no significant difference between two groups regarding TNF-alpha measurements. Some studies suggest different factors to be measured in order to predict preterm labor such as GMC-SF [13] or amniotic fluid concentration of metalloproteases [1] or maternal serum concentration of these metalloproteases [20] and here we can suggest different inflammatory cytokines measurements for prediction of preterm labor such as IL-8 and IL-13. But there is much to discover and none of these factors could predict preterm labor accurately.…”

Section: Serum Levels Preterm Groupmentioning

confidence: 86%

“…The subjects as outpatients were referred to Beheshti Hospital of Isfahan Province-Iran between 2014 to 2017. All subjects had Complete Blood Count (CBC), C-reactive protein, imaging such as ultrasound (abdominal and vaginal) and cultures (vaginal and urine).Inclusion criteria for preterm labor women were defined as women with gestational ages between 24 to 34 weeks, regular and persistent uterine and cervix length less than 25 mm [13] . All subjects had informed consent to participate in study and inclusion criteria for the control group was woman with delivery in term gestational age.…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Comparing of pro-inflammatory cytokines in the woman with preterm and term labors

Ghadimi¹,

Danaeiniya²,

Internationals³

2018

JGNB

View full text Add to dashboard Cite

Background: Preterm birth is one of the most important issues in obstetrics medicine and yet, the leading cause of morbidity and long-term disabilities such as neuro developmental impairments. There have been many studies trying to recognize responsible factors and develop new methods to predict and cure the condition. One important factor in preterm birth is immune system and immune factors such as cytokines. In this regard, we aimed to measure different cytokines in sera of mothers experiencing preterm birth.

show abstract

Section: Serum Levels Preterm Groupsupporting

confidence: 94%

Section: Serum Levels Preterm Groupsupporting

confidence: 94%

Section: Serum Levels Preterm Groupmentioning

confidence: 86%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Comparing of pro-inflammatory cytokines in the woman with preterm and term labors

Ghadimi¹,

Danaeiniya²,

Internationals³

2018

JGNB

View full text Add to dashboard Cite

show abstract

“…Further, in pregnant animals administered LPS, we found that nicotine exerted anti-inflammatory effects by decreasing LPS-induced increases in serum TNF-α and IL-6 concentrations, and rescued fetuses[26]. In pregnant women with threatened preterm labor, serum levels of inflammatory cytokines such as TNF-α and interleukin-10 (IL-10) are increased compared to controls without threatened preterm labor[34]. In the present study, the expression of TNF-α and IL-1β on macrophages in the cervix of pregnant mice with systemic inflammation induced by LPS was apparently enhanced compared to normal pregnant controls, while the expression of α7nAChR on macrophages and collagen content were reduced.…”

mentioning

confidence: 87%

Lipopolysaccharide-induced premature cervical ripening and inflammation in pregnant mice can be alleviated by nicotine

Han¹,

Ding²,

Lin³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Clinical treatment of preterm birth (PTB) is usually dependent on inhibiting uterine contractions. Such therapy is only effective in the short-term and cannot fundamentally low the incidence of PTB. Premature cervical maturation is another important cause of PTB; it is associated with invasion of macrophages, which produce proinflammatory cytokines. We previously found that activation of the alpha-7 nicotinic acetylcholine receptor (α7nAChR) by nicotine alleviates the systemic inflammatory response in murine models of lipopolysaccharide (LPS)-induced PTB, but the underlying mechanisms remain unclear. Methods Cervical tissues were collected from women in preterm and term labor. An animal model of PTB was established by administering 25 µg/kg lipopolysaccharide (LPS) to normal pregnant C57BL/6 mice on gestational day 16 (GD16). PTB animals received 1 mg/kg of α7nAChR agonist nicotine or nicotine combined with 1 µg/kg α7nAChR antagonist α-bungarotoxin (α-BGT) from GD14 to GD17. The gestational age, the rates of preterm birth and the survival rate of pups were recorded. Immunofluorescence staining were utilized for the quantification of α7nAChR expression on cervical macrophages and changes in macrophage polarization, RT-PCR was used to determine the mRNA levels of M1 and M2 macrophage biomarkers. Elisa assay was used to detect changes in fetal inflammation. Immunofluorescence staining and western blotting were used to investigate the signaling pathways underlying nicotine’s promoting LPS-induced conversion of M1 macrophage to M2 in the cervix of PTB animals. Results α7nAChR expression on cervical macrophages and cervical collagen content was decreased in PTB patients and murine models of LPS-induced PTB. The number of M1 cervical macrophages, other pro-inflammatory mediators in the cervix and fetal inflammation was unregulated in pregnant mice following LPS administration. Nicotine treatment reduced the rate of PTB, decreased fetal inflammation, improved maternal and neonatal outcome; nicotine also increased polarization of cervical macrophages toward the anti-inflammatory M2 phenotype possibly by suppressing activation of the MAP kinases JNK and ERK1/2 and nuclear translocation of NF-κB and rescuing the inhibited JAK2/STAT3 and PI3K/AKT pathways. The effects of nicotine were reversed by the selective α7nAChR antagonist α-bungarotoxin (α-BGT). Conclusions Our findings indicate that nicotine prevents LPS-induced cervical ripening and inflammatory response by inducing M2 macrophage polarization, and nicotine may serve as potential anti-premature cervical maturation agents for treatment of PTB.

show abstract

Effectiveness of the cervical pessary for the prevention of preterm birth in singleton pregnancies with a short cervix: a meta-analysis of randomized trials

Pérez‐López

Chedraui

Pérez-Roncero

et al. 2019

Arch Gynecol Obstet

View full text Add to dashboard Cite

Maternal serum cytokine levels in pregnancies complicated with threatened preterm labour

Abstract: TPL and preterm birth were related to inflammatory changes in the maternal side that correlate with cervical shortening and the initiation of uterine contractions.

Cited by 25 publications

References 29 publications

Comparing of pro-inflammatory cytokines in the woman with preterm and term labors

Comparing of pro-inflammatory cytokines in the woman with preterm and term labors

Lipopolysaccharide-induced premature cervical ripening and inflammation in pregnant mice can be alleviated by nicotine

Effectiveness of the cervical pessary for the prevention of preterm birth in singleton pregnancies with a short cervix: a meta-analysis of randomized trials

Contact Info

Product

Resources

About