Maternal serum cytokines in term and preterm labor

Nowak, Magdalena; Oszukowski, P; Pięta, Anna; Małafiej, E; Malinowski, Ann Kinga; Szpakowski, M; Wilczyński, Jacek R.; Wierzbicka, Elżbieta

doi:10.1016/s0020-7292(00)83222-1

Cited by 1 publication

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“…Tumor cells also secrete IL-8, which in turn can act as an autocrine inducer of tumor growth or paracrine modulator of host endothelial cells in angiogenesis. In several small studies, IL-8 levels were elevated in the serum and ovarian cystic fluid in patients with ovarian carcinoma [28,53,75,88]. Furthermore, Lokshin and colleagues demonstrated that IL-8 and anti-IL-8 antibody levels were increased in ovarian cancer patients and more specifically, that anti-IL-8 antibody levels correlated with early stage disease [75].…”

Section: Interleukin-8mentioning

confidence: 99%

Markers of Angiogenesis in Ovarian Cancer

Merritt

Sood

2007

Disease Markers

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Tumor development and progression are inherently dependent on the process of angiogenesis. Recently, anti-angiogenic therapy has started to show promise as an effective treatment strategy in many solid tumors including ovarian carcinoma. Unfortunately, lack of effective biomarkers presents a challenge for oncologists in treatment planning as well as monitoring response of new anti-vascular agents. Previously, quantification of angiogenesis by microvessel density analysis provided useful prognostic information, however, its utility following anti-angiogenic therapy remains to be determined. Moreover, since secreted cytokines play an active part in angiogenesis by mediating neovascularization in tumors, investigations have focused on their potential role to serve as candidate biomarkers of disease detection, prognosis, and treatment response. In this article, we review the role of key angiogenesis markers as potential biomarkers in ovarian carcinoma.

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