Maternal serum fetuin-A, leptin, and hs-CRP concentrations in gestational diabetes

Çalan, Mehmet; Yılmaz, Özgür; Altındağ, Tamer; Solak, Ahmet; Kebabcilar, Levent; Yuvanc, Huseyin Oguz; Dal, Tuba

doi:10.1530/endoabs.32.p386

Cited by 1 publication

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“…In this respect, Calan et al 2013 study conducted on pregnant women in Turkey was reported that GDM caused higher levels of serum leptin and positively affected insulin resistance. 21 On the other hand, Thagaard et al 2017 studied adiponectin and leptin as rst trimester biomarkers for GDM among 2590 pregnant women in Denmark and observed the highest serum leptin level in women with GDM than non-GDM women. Their study also showed that women with a higher BMI had higher levels of leptin concentration.…”

Section: Discussionmentioning

confidence: 99%

The Level of Serum Leptin in Non-Obese Women with and without Gestational Diabetes in Sulaimaniyah City, Iraq

Fattah

Rashid²

2023

Preprint

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Background: Obesity in pregnancy is correlated with pregnancy complications, including gestational diabetes mellitus (GDM). Objective:The present work was carried out to compare serum leptin levels in non-obese pregnant women with and without GDM. Methods: This study included 160 pregnant women with gestation ages of 28 – 35 weeks, of which 80 were in a study group (pregnant women with GDM) and the rest were in a control group (pregnant women without GDM). Participants’ age, family health history (Hx), previous Hx, gestational age, parity, and body mass index (BMI) were collected from the women using a questionnaire. Serum leptin level and fetal amniotic index (FAI) were also measured. Results: Significant differences were seen between both groups in terms of their age (p<0.001), parity (p=0.05), BMI (p<0.001), and leptin level (p<0.001) in which women with GDM had higher BMI and leptin levels. The results also indicated that leptin level in the GDM women was correlated with their parity (p=0.04) and BMI (p<0.001), such that multiparous women and overweight women had higher levels of serum leptin. Conclusion: Higher serum leptin was found in GDM women, and an increased gestational age was associated with increased leptin in both GDM and non-GDM women.

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Section: Discussionmentioning

confidence: 99%