Maternal Serum IgE, Cord Blood IgE, and Children’s Allergy: A Narrative Review

Abstract

Context: Asthma is chronic inflammatory disorder of the respiratory system in childhood. IgE has an important role in allergic disorders such as asthma. The aim of this study is to review the association between maternal serum IgE and incidence of childhood asthma. Evidence Acquisition: Three researchers searched all articles in PubMed, Scopus, Google and Embase databases related to maternal serum IgE, cord blood IgE, childhood asthma and incidence using key words such as maternal IgE, cord blood IgE, relation, association, childhood asthma, child allergy. Results: We found a few related articles on the topic of maternal IgE, cord blood IgE, and childhood asthma. We reviewed 11 articles for this study. Parental atopy and allergy are more important predictive factors for children's allergies such as asthma. IgE levels was higher in children whose mothers had higher IgE levels. Total IgE level was significantly higher in boys compared to girls. Conclusions: Increasing maternal and cord blood IgE may be a predictive factor for development of children asthma. More data is needed to clearify this relation.