Maternal serum interleukin 1, 2, 6, 8 and interleukin-2 receptor levels in preterm labor and delivery

Rebollo, Francisco Javier Medel; Codoceo, Rosa; González, Antonio G.; Álvarez-de-la-Rosa, Margarita

doi:10.1016/s0301-2115(99)00129-3

Cited by 37 publications

(3 citation statements)

References 15 publications

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“…The preterm delivery group was found to have significantly elevated IL-2 receptor levels and IL-6 levels were found to be significantly lower in the preterm delivery group among those who responded to tocolytics compared with non-responders. This study suggested that maternal serum IL-6 and IL-2 receptor levels might be of benefit in determining preterm labor and a possible response to tocolytics (25).…”

Section: Discussionmentioning

confidence: 76%

Is Amniotic Fluid Analysis During the Second Trimester a Predictor for the Detection of Preterm Labor?

Koçyiğit¹,

Çelik²,

Şi̇mşek³

2020

J Istanb Fac Med

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Strese bağlı hipotalamik-pitüiter-adrenal aksın prematür aktivasyonu preterm doğumu başlatır. Etiyopatogenezi açıklamak üzere pek çok mekanizma ileri sürülmüştür. En önemlisi klinik ve subklinik koryoamniyonittir. Preterm eylem riski taşıyan hastaların daha erken dönemde belirlenmesi, önlenmesi ve hastaların yanlış tanı nedeni ile gereksiz yere tokoliz tedavisi almasının önlenmesini amaçladık. Gereç ve Yöntem: Çalışmamızda 16-26 gebelik haftalarında 125 tekiz gebe, onamı alınarak çalışmaya dahil edildi. Hastalardan 3'ünde karyotip anomalisi (Trizomi 21) saptandı, 1 hastanın gebeliği şiddetli preeklampsi nedeni ile 32. haftada sonlandırıldı, 5 hastaya da ulaşılamadı. Yüz on altı hasta ile çalışmaya devam edildi. Amniyosentez işlemi alınan ilk 2 cc'lik amniyon mayisi kullanılarak glukoz, IL-1, IL-6, HsCRP, hücre sayımı, elektrolit ve progesteron/estrojen oranı çalışıldı. Bulgular: Gebelerin 16'sı 37. haftasını doldurmadan doğum yaptı (%13,8). Çalışma popülasyonun ortalama yaşı 33,2±6,25 idi. Çalışmamızda preterm doğum yapan grup ile miyadında doğum yapan grubun yaş ortalaması istatistiksel olarak benzer bulundu (36,06±3,91 vs 32,77±6,43). Ayrıca her iki grupta hastaların amniyon mayisindeki glukoz, IL-1, IL-6, HsCRP, hücre sayımı, elektrolit ve progesteron/estrojen oranı istatiksel olarak anlamlı bulunmadı. Sonuç: Çalışmamızda preterm eylemin etiyolojisinde suçlanan subklinik enfeksiyon ve steroid hormon değişimleri incelenmiş ve bu hipotezleri destekleyen kanıt bulunamamıştır.

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Section: Discussionmentioning

confidence: 76%

Is Amniotic Fluid Analysis During the Second Trimester a Predictor for the Detection of Preterm Labor?

Koçyiğit¹,

Çelik²,

Şi̇mşek³

2020

J Istanb Fac Med

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“…Few studies have demonstrated the relevance of IL-2 and its receptor in the pathogenesis of preterm labor; a possible explanation is that in normal pregnancy, the concentrations of IL-2 and its receptor are relatively low and difficult to measure. But in the case of preterm labor, an increase of this interleukin has been demonstrated indeed, which could imply the chronicity of an inflammatory process and not the acute response as in the case of IL-6 [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

A Novel Predictive Machine Learning Model Integrating Cytokines in Cervical-Vaginal Mucus Increases the Prediction Rate for Preterm Birth

Borboa-Olivares,

Rodríguez-Sibaja,

Espejel-Nuñez

et al. 2023

IJMS

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Preterm birth (PB) is a leading cause of perinatal morbidity and mortality. PB prediction is performed by measuring cervical length, with a detection rate of around 70%. Although it is known that a cytokine-mediated inflammatory process is involved in the pathophysiology of PB, none screening method implemented in clinical practice includes cytokine levels as a predictor variable. Here, we quantified cytokines in cervical-vaginal mucus of pregnant women (18–23.6 weeks of gestation) with high or low risk for PB determined by cervical length, also collecting relevant obstetric information. IL-2, IL-6, IFN-γ, IL-4, and IL-10 were significantly higher in the high-risk group, while IL-1ra was lower. Two different models for PB prediction were created using the Random Forest machine-learning algorithm: a full model with 12 clinical variables and cytokine values and the adjusted model, including the most relevant variables-maternal age, IL-2, and cervical length- (detection rate 66 vs. 87%, false positive rate 12 vs. 3.33%, false negative rate 28 vs. 6.66%, and area under the curve 0.722 vs. 0.875, respectively). The adjusted model that incorporate cytokines showed a detection rate eight points higher than the gold standard calculator, which may allow us to identify the risk PB risk more accurately and implement strategies for preventive interventions.

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“…Either Alvarez-de-la-Rosa et al . [30] noted that the concentration of IL-6 and IL-8 in preterm women were higher in comparison to those who were not in labor, although this difference was not statistically significant. Dissimilarity to our findings in another study Bahar et al .…”

Section: Discussionmentioning

confidence: 99%

Maternal serum cytokines in the prediction of preterm labor and response to tocolytic therapy in preterm labor women

Shahshahan

Hashemi

2014

Adv Biomed Res

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Background:One of the most important challenges in health care system is prevention of preterm birth. The present study was aimed to investigate the relation between interleukins 6 and 8 (IL-6 and IL-8) with preterm labor and response to tocolytic therapy.Materials and Methods:In the year 2012, 75 women with the symptoms of preterm labor (cases) in compare with 75 term women (controls) were randomly selected and evaluated. Baseline data and serum levels of IL-6 and IL-8 (using immunoassay method) recorded. Hence, tocolysis in women in case group was performed with the use of magnesium sulfate and then they were followed until delivery time to assess the response to treatment.Results:In case group, 59 women response to tocolytic treatment and delivered at term but 16 of them delivered prematurely. The curve constructed cut-off value for IL-6 was >37.9 (area under the curve [AUC], 0.674; standard error [SE], 0.043; P < 0.0001), and > 9.5 for IL-8 (AUC, 0.773; SE, 0.038; P < 0.0001), indicating a significant relationship with preterm labor. Furthermore, there was a significant relationship between serum IL-6 and IL-8 levels with the response to the treatment in cut-off >45 for IL-6 (AUC, 0.894; SE, 0.042; P < 0.0001) and >171 for IL-8 (AUC, 0.864; SE, 0.059; P < 0.0001).Conclusion:In summary, our results suggest that the assessment of maternal serum concentrations of IL-6 and IL-8 can be used as appropriate biomarkers for predicting preterm labor and response to tocolytic therapy in these women. However, further studies needs to be done.

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Maternal serum interleukin 1, 2, 6, 8 and interleukin-2 receptor levels in preterm labor and delivery

Cited by 37 publications

References 15 publications

Is Amniotic Fluid Analysis During the Second Trimester a Predictor for the Detection of Preterm Labor?

Is Amniotic Fluid Analysis During the Second Trimester a Predictor for the Detection of Preterm Labor?

A Novel Predictive Machine Learning Model Integrating Cytokines in Cervical-Vaginal Mucus Increases the Prediction Rate for Preterm Birth

Maternal serum cytokines in the prediction of preterm labor and response to tocolytic therapy in preterm labor women

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