Maternal serum laeverin (aminopeptidase Q) measured in the first trimester of pregnancy does not predict preeclampsia

Abstract

First trimester maternal serum laeverin level cannot be used to predict preeclampsia.

Galectin-13 and Laeverin Levels Interfere with Human Fetoplacental Growth

“…It is also contradictory that the serum level of laeverin was 0.93 ± 0.74 ng/mL up to 22 weeks of gestation in our study, whereas laeverin levels were higher in another study (median: 6.9 ng/mL at the 22nd gestational weeks) [ 19 ]. Furthermore, leverin concentration ranged in the serum between 41 and 393 ng/mL at a dilution of 1:50, during 8–14 weeks [ 21 ], which is also in contrast to the finding of much lower protein levels in our sample and in a previous study [ 19 ]. A possible reason for the discordance with other studies could be the use of different population and minor alterations among measurement kits [ 19 , 21 ].…”

“…The evaluation of serum laeverin levels was based on optical density measurements [ 19 ] or dilution series assessments [ 21 ] using a distinctly different assay than that utilized by our research group, although the kit analytes might be the same. The characteristics of the kits are not the same, e.g., intra- and inter-assay coefficient of variation, sensitivity [ 19 , 21 ]. Commercial kits detect a wide range of amino acid sequences of laeverin (818–905) capturing all types of isoforms of the protein (113 kDa, 130 kDA, 160 kDa and 231 kDa) [ 26 ].…”

“…Commercial kits detect a wide range of amino acid sequences of laeverin (818–905) capturing all types of isoforms of the protein (113 kDa, 130 kDA, 160 kDa and 231 kDa) [ 26 ]. Another study did not find a significant difference in the serum laeverin levels between the PE and the reference group, with an increasing tendency during the first trimester in both groups [ 21 ]. Notably, the laeverin levels decrease from the mid-trimester to term, which may reflect the declining physiological role of the laeverin in the third trimester [ 19 ].…”

“…An increasing amount of literature is reporting on the potential role of laeverin in the pathomechanisms of preeclampsia, since preeclamptic trophoblasts overproduce laeverin [ 17 , 18 , 19 ] and ectopic intracellular expression of the protein [ 20 ] could be observed in preeclamptic placenta. Laeverin can be detected in the maternal serum [ 19 , 21 ] since EVT releases it into the maternal circulation. A lower circulating level might be a prognosticator of preeclampsia since the abundant laeverin is entrapped in the placenta [ 19 ], a disease with impaired uterine vascularity and placentation.…”

Obstetric and perinatal aspects of multiple pregnancy

“…Ускладненнями БВ є ранній токсикоз, який фіксують при цьому у 2 рази частіше (55,4%, зокрема у 61,5% і 53,5% відповідно при монохоріальній і дихоріальній двійнях), ніж при одноплідній вагітності [69,94]. Загрозу переривання вагітності у I і II триместрах діагностують у 65,2% і 73,2% пацієнток з монохоріальною і дихоріальною двійнями, що у 3 рази перевищує показники при одноплідній вагітності [59].…”