Maternal serum perfluoroalkyl substance mixtures and thyroid hormone concentrations in maternal and cord sera: The HOME Study

Lebeaux, Rebecca M.; Doherty, Brett T.; Gallagher, Lisa G.; Zoeller, R. Thomas; Hoofnagle, Andrew N.; Calafat, Antònia M.; Karagas, Margaret R.; Yolton, Kimberly; Chen, Aimin; Lanphear, Bruce P.; Braun, Joseph M.; Romano, Megan E.

doi:10.1016/j.envres.2020.109395

Cited by 54 publications

(19 citation statements)

References 52 publications

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“…The potential effect of maternal autoimmunity was also addressed by Lebeaux et al. ( 76 ) in a study examining data coming from a prospective cohort, the Health Outcomes and Measures of the Environment (HOME) Study, in which 468 pregnant women and their children coming from the Cincinnati area in US were enrolled. In particular the authors assessed the possible associations between TSH, FT3, FT4, TT4, and TT3 in maternal and cord blood and levels of four different PFAS (PFOA, PFOS, PFNA, and PFHxS) in the same samples.…”

Section: Prenatal Exposure To Pfas: Effects On Maternal and Neonatal mentioning

confidence: 99%

Thyroid Disrupting Effects of Old and New Generation PFAS

et al. 2021

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Per- and polyfluoroalkyl substances (PFAS) represent a group of synthetic compounds widely used in industry plants due to their low grade of degradation, surfactant properties, thermic and flame resistance. These characteristics are useful for the industrial production, however they are also potentially dangerous for human health and for the environment. PFAS are persistent pollutants accumulating in waters and soil and recoverable in foods due to their release by food packaging. Humans are daily exposed to PFAS because these compounds are ubiquitous and, when assimilated, they are difficult to be eliminated, persisting for years both in humans and animals. Due to their persistence and potential danger to health, some old generation PFAS have been replaced by newly synthesized PFAS with the aim to use alternative compounds presumably safer for humans and the environment. Yet, the environmental pollution with PFAS remains a matter of concern worldwide and led to large-scale epidemiological studies both on plants’ workers and on exposed people in the general population. In this context, strong concern emerged concerning the potential adverse effects of PFAS on the thyroid gland. Thyroid hormones play a critical role in the regulation of metabolism, and thyroid function is related to cardiovascular disease, fertility, and fetal neurodevelopment. In vitro, ex vivo data, and epidemiological studies suggested that PFASs may disrupt the thyroid hormone system in humans, with possible negative repercussions on the outcome of pregnancy and fetal-child development. However, data on the thyroid disrupting effect of PFAS remain controversial, as well as their impact on human health in different ages of life. Aim of the present paper is to review recent data on the effects of old and new generation PFAS on thyroid homeostasis. To this purpose we collected information from in vitro studies, animal models, and in vivo data on exposed workers, general population, and pregnant women.

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Section: Prenatal Exposure To Pfas: Effects On Maternal and Neonatal mentioning

confidence: 99%

Thyroid Disrupting Effects of Old and New Generation PFAS

et al. 2021

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“…Aimuzi et al’s study [ 21 ] used sparse partial least squares regression to identify the dominant PFASs related to FT4, FT3, and TSH in cord blood, while the model did not estimate the joint effects of the PFAS mixture. Two studies from the US [ 33 , 34 ] also used BKMR to assess the overall effects of prenatal PFAS mixture exposure on neonatal THs. The study based on the Project Viva cohort [ 33 ] showed a statistically non-significant inverse association between the PFAS mixture and lower T4 concentrations (T3 and FT3 not measured) in heel stick blood and no association with TSH, which is consistent with our findings.…”

Section: Discussionmentioning

confidence: 99%

“…The study based on the Project Viva cohort [ 33 ] showed a statistically non-significant inverse association between the PFAS mixture and lower T4 concentrations (T3 and FT3 not measured) in heel stick blood and no association with TSH, which is consistent with our findings. However, the study based on the HOME study [ 34 ] did not find any association between the PFAS mixture (PFOA, PFOS, PFNA, and PFHxS) and any TH in cord blood. For the single exposure effects of PFASs, our results were partially consistent with those of previous epidemiological studies.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, our finding that maternal PFNA was associated with decreased cord TSH is consistent with three previous studies [ 21 , 22 , 36 ], and that of maternal PFOA being associated with increased TSH is consistent with Kim’s study [ 12 ]. Other studies that have examined PFAS exposure and TH concentrations tended to report that PFAS exposure was associated with decreased T4 (or FT4) and/or T3 with different compounds showing statistical significance [ 11 , 19 , 20 , 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

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Prenatal exposure to perfluoroalkyl substances and thyroid hormone concentrations in cord plasma in a Chinese birth cohort

et al. 2020

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Background Evidence of associations between prenatal exposure to perfluoroalkyl substances (PFASs) and fetal thyroid hormones (THs) is controversial, and few studies have estimated the associations, while addressing the high correlations among multiple PFASs. We aimed to examine the associations between prenatal PFAS exposure and thyroid hormone concentrations in cord blood. Methods A total of 300 mother-infant pairs from the Shanghai-Minhang Birth Cohort Study were included. We measured the concentrations of eight PFASs in maternal plasma samples collected at 12–16 gestational weeks, as well as those of total thyroxine (T4), free T4 (FT4), total triiodothyronine (T3), free T3 (FT3), and thyroid stimulating hormone (TSH) in cord plasma. We estimated the associations between maternal PFAS concentrations and TH concentrations using linear regression and Bayesian kernel machine regression (BKMR) models. Results In BKMR models, higher PFAS mixture concentrations were associated with increased T3 concentrations, and there were suggestive associations with increased FT3 concentrations. For single-exposure effects in BKMR models, a change in PFDA, PFUdA, and PFOA concentrations from the 25th to 75th percentile was associated with a 0.04 (95%CrI: − 0.01, 0.09), 0.02 (95%CrI: − 0.03, 0.07), and 0.03 (95%CrI: − 0.001, 0.06) nmol/L increase in T3 concentrations, respectively. PFOA, PFNA, and PFDA were the predominant compounds in PFASs-FT3 associations, and the corresponding estimates were 0.11 (95% CrI: 0.02, 0.19), − 0.17 (95% CrI: − 0.28, − 0.07), and 0.12 (95% CrI: − 0.004, 0.24) pmol/L, respectively. A change in PFNA and PFOA concentrations from the 25th to 75th percentile was associated with a − 1.69 (95% CrI: − 2.98, − 0.41) μIU/mL decrease and a 1.51 (95% CrI: 0.48, 2.55) μIU/mL increase in TSH concentrations. The associations of PFOA and PFNA with T3/FT3 were more pronounced in boys, while those with TSH were more pronounced in girls. Conclusion Our results suggest that prenatal exposure to multiple PFASs was associated with thyroid hormones in cord blood. However, individual PFAS had varied effects—differing in magnitude and direction—on fetal thyroid hormones.

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“…Beyond disrupting maternal TH homeostasis, PFAS can be transferred from maternal circulation to the fetus to alter fetal TH levels. Several studies included in this review examined the impact of PFAS on fetal THs by measuring the association of PFAS levels with cord blood and neonatal heel stick TH levels [ 80 , 81 , 83 , 86 , 87 ]. While results varied, maternal PFAS levels were generally positively associated with fetal and neonatal TSH and negatively with T3 and T4.…”

Section: Pfas Exposure and Risk Of Gestational Diabetes Mellitus (Gdm) Development And Candidate Biomarkers: Evidence In The Literaturementioning

confidence: 99%

A pathway level analysis of PFAS exposure and risk of gestational diabetes mellitus

et al. 2021

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Per- and polyfluoroalkyl substances (PFAS) have been found to be associated with gestational diabetes mellitus (GDM) development, a maternal health disorder in pregnancy with negative effects that can extend beyond pregnancy. Studies that report on this association are difficult to summarize due to weak associations and wide confidence intervals. One way to advance this field is to sharpen the biologic theory on a causal pathway behind this association, and to measure it directly by way of molecular biomarkers. The aim of this review is to summarize the literature that supports a novel pathway between PFAS exposure and GDM development. Epidemiological studies demonstrate a clear association of biomarkers of thyroid hormones and glucose metabolism with GDM development. We report biologic plausibility and epidemiologic evidence that PFAS dysregulation of maternal thyroid hormones and thyrotropin (TSH) may disrupt glucose homeostasis, increasing the risk of GDM. Overall, epidemiological studies demonstrate that PFAS were positively associated with TSH and negatively with triiodothyronine (T3) and thyroxine (T4). PFAS were generally positively associated with glucose and insulin levels in pregnancy. We propose dysregulation of thyroid function and glucose metabolism may be a critical and missing component in the accurate estimation of PFAS on the risk of GDM.

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Maternal serum perfluoroalkyl substance mixtures and thyroid hormone concentrations in maternal and cord sera: The HOME Study

Cited by 54 publications

References 52 publications

Thyroid Disrupting Effects of Old and New Generation PFAS

Thyroid Disrupting Effects of Old and New Generation PFAS

Prenatal exposure to perfluoroalkyl substances and thyroid hormone concentrations in cord plasma in a Chinese birth cohort

A pathway level analysis of PFAS exposure and risk of gestational diabetes mellitus

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