Maternal thrombocytopenia at term: a population‐based study

Sainio, Susanna; Kekomäki, Riitta; Riikonen, Seija; Teramo, Kari

doi:10.1034/j.1600-0412.2000.079009744.x

Cited by 170 publications

(119 citation statements)

References 16 publications

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“…The incidence of thrombocytopenia in this study was 11.68%. This figure was higher than figures of 11.6% reported by Boehlen et al in and 7.2% reported by Sainio et al 2,3 The higher prevalence in this study may be because of malaria and dengue infections. The present study found no influence of age and religion on prevalence of thrombocytopenia in pregnancy like Mathews et al 10 From our findings, gestational thrombocytopenia occurred across the three trimesters.…”

Section: Discussioncontrasting

confidence: 68%

Thrombocytopenia during pregnancy: an institutional based prospective study of one year

Pandey¹,

Singh²

2017

Int J Res Med Sci

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Background: Platelets are non-nucleated cellular fragments of megakaryocytes, they play a critical role in haemostasis. Thrombocytopenia, defined as blood platelet count below 150.000/μL is the second leading cause of blood disorders in pregnancy after anemia. It complicates 7 to 10% of all pregnancies. Gestational thrombocytopenia explains 70-80% of all cases of thrombocytopenia in pregnancy. Hypertensive disorders account for approximately 20% and immune thrombocytopenic purpura for about 3-4%. Other etiologies are considered rare in pregnancy.Methods: The study was conducted in the tertiary institute over a period of one year, from January 2016 to December 2016. The samples of blood were collected from the Antenatal out-patient department and from indoor patients of the department of gynecology and obstetrics of the J.K. Hospital, Bhopal, Madhya Pradesh India.Results: Maximum number of patients had moderate degree of anemia around 58%. Most of the cases presented during 30-34 weeks of gestation. The most common etiology was gestational thrombocytopenia.Conclusions: Thrombocytopenia in pregnancy may occur secondary to a variety of causes. Most of these cases occur during specific periods of gestation. Management of pregnant women with platelet disorders requires a multidisciplinary approach and close collaboration between obstetric and hepatologist.

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Section: Discussioncontrasting

confidence: 68%

Thrombocytopenia during pregnancy: an institutional based prospective study of one year

Pandey¹,

Singh²

2017

Int J Res Med Sci

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“…In the present study, incidence of thrombocytopenia during pregnancy was 8.8%. Burrows [2], found thrombocytopenia in 6% and Sainio et al [5] reported a 7.3% prevalence of thrombocytopenia in a population based surveillance study. Thus, the prevalence of thrombocytopenia in Indian population is similar to world literature (5-12%).…”

Section: Discussionmentioning

confidence: 95%

“…Silver [12] & Aster et al [13] reported that mostly GT is detected incidentally and women have no symptoms. Sainio et al [5] reported that cases of GT have no impact on either the mother or the fetus. GT was the most common cause in this study with a platelet count ranging from 65,000 to 135000 ll -1 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Characterization of Thrombocytopenia in Pregnancy in Indian Women

Singh

Dhakad

Uma

et al. 2011

Indian J Hematol Blood Transfus

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To find the prevalence and causes of thrombocytopenia during pregnancy. An analytical prospective observational study was conducted in Department of Obstetrics & Gynecology, CSMMU, Lucknow. 1079 antenatal women screened for thrombocytopenia and investigated for cause and management strategies and fetomaternal outcome were recorded. Prevalence of thrombocytopenia was 8.8%. Gestational thrombocytopenia was seen in 64.2%, obstetric in 22.1% and medical in 13.68% cases. Mean platelet count in controls was lower with a significant fall (P \ 0.001) in the platelet count as pregnancy advanced. Hypertensive and hepatic disorders were the most common obstetric causes of thrombocytopenia. Mode of delivery was not affected by thrombocytopenia. Maternal morbidity and mortality was seen only in medical and obstetric thrombocytopenia. The low platelet counts and declining trend with increasing gestational age predispose Indian women to risk of thrombocytopenia and a routine platelet count is suggested.

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“…Sejeny in 1975 [6] was the first to report gestational thrombocytopenia in 405 healthy pregnant women using electronic particle counter [6]. Since then, a number of global reports described a sequential reduction of platelet count as pregnancy advances [7][8][9][10][11][12][13][14][15][16][17][18] with a 10-20% fall in platelet count [19]. Frequency of gestational thrombocytopenia was estimated to be 7-12% at term [12,14,15].…”

Section: Quantitative Changes In Plateletsmentioning

confidence: 99%

“…Since then, a number of global reports described a sequential reduction of platelet count as pregnancy advances [7][8][9][10][11][12][13][14][15][16][17][18] with a 10-20% fall in platelet count [19]. Frequency of gestational thrombocytopenia was estimated to be 7-12% at term [12,14,15]. A platelet count of 80 x 10 9 /L is considered to be a safe threshold [20] with no impact on either mother [21] or the fetus [15], unless the thrombocytopenic mother has some comorbids [14].…”

Section: Quantitative Changes In Plateletsmentioning

confidence: 99%

A Review of Hemostasis in Normal Pregnancy and Puerperium

Moiz¹

2017

Natl. j. health sci.

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Significant alterations are seen in hemostatic system during normal pregnancy and puerperium. Overall, it is a state of hypercoagulability and hypofibrinolysis mitigating the risk of severe bleeding during placental separation at delivery. On the flip side, it threatens a pregnant woman for thrombosis with the risk being four to six folds more in comparison to a non-pregnant woman. It is important to understand the hemostatic changes in normal pregnancy by all health care providers who manage pregnant women in obstetric wards, trauma, anesthesia and other circumstances. This review describes the changes in qualitative and quantitative changes in platelet, clotting factors, anticoagulants and fibrinolysis during normal pregnancy and puerperium.

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Maternal thrombocytopenia at term: a population‐based study

Abstract: Women with gestational thrombocytopenia do not require alteration of their treatment. Fetal blood sampling is not considered necessary when thrombocytopenia is discovered unexpectedly at term.

Cited by 170 publications

References 16 publications

Thrombocytopenia during pregnancy: an institutional based prospective study of one year

Thrombocytopenia during pregnancy: an institutional based prospective study of one year

Prevalence and Characterization of Thrombocytopenia in Pregnancy in Indian Women

A Review of Hemostasis in Normal Pregnancy and Puerperium

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