Maternal urinary cadmium concentrations in relation to preterm birth in the Healthy Baby Cohort Study in China

Yang, Jie; Huo, Wenqian; Zhang, Bin; Zheng, Tongzhang; Li, Yuanyuan; Pan, Xinyun; Liu, Wenyu; Chang, Huailong; Jiang, Minmin; Zhou, Aifen; Qian, Zhengmin; Wan, Yanjian; Xia, Wei

doi:10.1016/j.envint.2016.06.003

Cited by 87 publications

(34 citation statements)

References 46 publications

(64 reference statements)

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“…In many studies, prenatal arsenic, cadmium and lead exposure were inversely associated with anthropological parameters of newborns, such as birth weight, birth length, and head circumference [ 8 , 13 , 14 , 15 , 16 , 17 ]. Moreover, exposure to these metals also increased the likelihood of preterm delivery [ 18 , 19 , 20 ]. Exposure to inorganic arsenic during pregnancy was also positively associated with stillbirth and miscarriage [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Prenatal Heavy Metal Exposure and Adverse Birth Outcomes in Myanmar: A Birth-Cohort Study

Wai

Mar

Kosaka

et al. 2017

IJERPH

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Arsenic, cadmium and lead are well-known environmental contaminants, and their toxicity at low concentration is the target of scientific concern. In this study, we aimed to identify the potential effects of prenatal heavy metal exposure on the birth outcomes among the Myanmar population. This study is part of a birth-cohort study conducted with 419 pregnant women in the Ayeyarwady Division, Myanmar. Face-to-face interviews were performed using a questionnaire, and maternal spot urine samples were collected at the third trimester. Birth outcomes were evaluated at delivery during the follow up. The median values of adjusted urinary arsenic, cadmium, selenium and lead concentration were 74.2, 0.9, 22.6 and 1.8 μg/g creatinine, respectively. Multivariable logistic regression revealed that prenatal cadmium exposure (adjusted odds ratio (OR) = 1.10; 95% confidence interval (CI): 1.01–1.21; p = 0.043), gestational age (adjusted OR = 0.83; 95% CI: 0.72–0.95; p = 0.009) and primigravida mothers (adjusted OR = 4.23; 95% CI: 1.31–13.65; p = 0.016) were the predictors of low birth weight. The present study identified that Myanmar mothers were highly exposed to cadmium. Prenatal maternal cadmium exposure was associated with an occurrence of low birth weight.

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Section: Introductionmentioning

confidence: 99%

Prenatal Heavy Metal Exposure and Adverse Birth Outcomes in Myanmar: A Birth-Cohort Study

Wai

Mar

Kosaka

et al. 2017

IJERPH

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“…Data for this study were extracted from the Wuhan Healthy Baby Cohort (WHBC), specifically designed to investigate factors associated with child growth and development. The detailed proposal of this cohort has been described previously 18. In the present study, we included a subgroup of infants who were born at the Women and Children’s Hospital of Wuhan, China between October 2012 and September 2013 and who have complete healthcare records within 6 months after birth.…”

Section: Methodsmentioning

confidence: 99%

Association between birth weight and neurodevelopment at age 1–6 months: results from the Wuhan Healthy Baby Cohort

et al. 2020

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ObjectiveThe association between birth weight and infants’ neurodevelopment is not well understood. We aimed to examine the impact of birth weight on neurodevelopment of infants at age 1–6 months using data from the Wuhan Healthy Baby Cohort (WHBC) study.Setting and participantsThis is a prospective cohort study of 4026 infants from the WHBC study who were born at the Women and Children’s Hospital of Wuhan, China between October 2012 and September 2013 and who had complete healthcare records within 6 months after birth. Participants were categorised into three groups according to their birth weight: low birth weight (LBW; birth weight <2500 g), normal birth weight (2500 g ≤ birth weight <4000 g) and macrosomia (birth weight ≥4000 g).Main outcome measuresThe main outcomes were development quotient (DQ) and clinical diagnosis of neurodevelopmental delay. Both adjusted regression coefficients and ORs were estimated for LBW and macrosomia.ResultsOf the 4026 infants, 166 (4.12%) were of LBW and 237 (5.89%) were with macrosomia. Adjusted regression coefficients of LBW and macrosomia for gross motor DQ were −11.18 (95% CI −11.36 to 10.99) and 0.49 (95% CI 0.36 to 0.63), fine motor DQ −6.57 (95% CI −6.76 to −6.39) and −2.73 (95% CI −2.87 to −2.59), adaptability DQ −4.87 (95% CI −5.05 to −4.68) and −1.19 (95% CI −1.33 to −1.05), language DQ −6.23 (95% CI −6.42 to −6.05) and 0.43 (95% CI 0.29 to 0.57), and social behaviour DQ −6.82 (95% CI −7.01 to −6.64) and 1.10 (95% CI 0.96 to 1.24). Adjusted OR of LBW for clinical diagnosis of ‘neurodevelopmental delay’ in gross motor was 2.43 (95% CI 1.65 to 3.60), fine motor 1.49 (95% CI 1.01 to 2.19) and adaptability 1.56 (95% CI 1.06 to 2.31). LBW has no significant effects on ‘neurodevelopmental delay’ in language and social behaviour, and macrosomia has no significant effects on clinical diagnosis of ‘neurodevelopmental delay’ in all domains.ConclusionBoth LBW and macrosomia are associated with infants’ DQ, and LBW increases the risk of being diagnosed with ‘neurodevelopmental delay’ in gross motor, fine motor and adaptability among infants aged 1–6 months.

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“…More recently two large cohort studies conducted in China showed an association between higher levels of cadmium exposure and increased risk of PTB (106, 107). A case-cohort study of the more restrictive outcomes of preterm low birthweight also reported this association (108).…”

Section: Environmental Chemicals and Ptbmentioning

confidence: 99%

“…A case-cohort study of the more restrictive outcomes of preterm low birthweight also reported this association (108). Cadmium is thought to alter zinc transport, which may trigger PTB (106, 107) and may also accumulate in the placenta where it can directly or indirectly affect the fetus (108). None of the studies that reviewed mercury or arsenic proposed a hypothesized mechanism of action.…”

Section: Environmental Chemicals and Ptbmentioning

confidence: 99%

Environmental Chemicals and Preterm Birth: Biological Mechanisms and the State of the Science

2017

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Purpose of review Preterm birth is a significant worldwide health problem of uncertain origins. The extant body of literature examining environmental contaminant exposures in relation to preterm birth is extensive but results remain ambiguous for most organic pollutants, metals and metalloids, and air pollutants. In the present review we examine recent epidemiologic studies investigating these associations, and identify recent advances and the state of the science. Additionally, we highlight biological mechanisms of action in the pathway between chemical exposures and preterm birth, including inflammation, oxidative stress, and endocrine disruption, that deserve more attention in this context. Recent findings Important advances have been made in the study of the environment and preterm birth, particularly in regard to exposure assessment methods, exploration of effect modification by co-morbidities and exposures, and in identification of windows of vulnerability during gestation. There is strong evidence for an association between maternal exposure to some persistent pesticides, lead, and fine particulate matter, but data on other contaminants is sparse and only suggestive trends can be noted with the current data. Summary Beyond replicating current findings, further work must be done to improve understanding of mechanisms underlying the associations observed between environmental chemical exposures and preterm birth. By examining windows of vulnerability, disaggregating preterm birth by phenotypes, and measuring biomarkers of mechanistic pathways in these epidemiologic studies we can improve our ability to detect associations with exposure, provide additional evidence for causality in an observational setting, and identify opportunities for intervention.

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Maternal urinary cadmium concentrations in relation to preterm birth in the Healthy Baby Cohort Study in China

Cited by 87 publications

References 46 publications

Prenatal Heavy Metal Exposure and Adverse Birth Outcomes in Myanmar: A Birth-Cohort Study

Prenatal Heavy Metal Exposure and Adverse Birth Outcomes in Myanmar: A Birth-Cohort Study

Association between birth weight and neurodevelopment at age 1–6 months: results from the Wuhan Healthy Baby Cohort

Environmental Chemicals and Preterm Birth: Biological Mechanisms and the State of the Science

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