Maternal vitamin D deficiency during pregnancy results in insulin resistance in rat offspring, which is associated with inflammation and Iκbα methylation

Zhang, Huaqi; Chu, Xia; Huang, Yifan; Li, Gang; Wang, Yuxia; Liu, Ying; Sun, Changhao

doi:10.1007/s00125-014-3316-7

Cited by 54 publications

(57 citation statements)

References 33 publications

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“…Moreover, NFKB inhibitor-a (NFKBIA) (also known as hepatic IjBa) is increased by RV. This gene plays an important role in persistent inflammation, and its decrease is associated with 25(OH)-VitD3 deficiency [33]. Conversely, retinoid X receptor b (RXRB), which forms a complex with the VitD receptor (VDR) and would be necessary to activate VDR targets [34], is decreased in the PBMCs of control children by RV.…”

Section: Gene Arrays From In-vitro Rv-infected Pbmcs From Preschool Cmentioning

confidence: 99%

Soluble ST2 regulation by rhinovirus and 25(OH)-vitamin D3 in the blood of asthmatic children

Haag

Sharma

Rauh

et al. 2018

Clinical and Experimental Immunology

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Paediatric asthma exacerbations are often caused by rhinovirus (RV). Moreover, 25(OH)-vitamin D3 (VitD3) deficiency during infancy was found associated with asthma. Here, we investigated the innate immune responses to RV and their possible modulation by 25(OH)-VitD3 serum levels in a preschool cohort of children with and without asthma. The innate lymphoid cell type 2 (ILC2)-associated marker, ST2, was found up-regulated in the blood cells of asthmatic children with low serum levels of 25(OH)-VitD3 in the absence of RV in their airways. Furthermore, in blood cells from control and asthmatic children with RV in their airways, soluble (s) ST2 (sST2) protein was found reduced. Asthmatic children with low 25(OH)-VitD3 in serum and with RV in vivo in their airways at the time of the analysis had the lowest sST2 protein levels in the peripheral blood compared to control children without RV and high levels of 25(OH)-VitD3. Amphiregulin (AREG), another ILC2-associated marker, was found induced in the control children with RV in their airways and low serum levels of 25(OH)-VitD3. In conclusion, the anti-inflammatory soluble form of ST2, also known as sST2, in serum correlated directly with interleukin (IL)-33 in the airways of asthmatic children. Furthermore, RV colonization in the airways and low serum levels of 25(OH)-VitD3 were found to be associated with down-regulation of sST2 in serum in paediatric asthma. These data indicate a counter-regulatory role of 25(OH)-VitD3 on RV-induced down-regulation of serum sST2 in paediatric asthma, which is relevant for the therapy of this disease.

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Section: Gene Arrays From In-vitro Rv-infected Pbmcs From Preschool Cmentioning

confidence: 99%

Soluble ST2 regulation by rhinovirus and 25(OH)-vitamin D3 in the blood of asthmatic children

Haag

Sharma

Rauh

et al. 2018

Clinical and Experimental Immunology

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“…Studies in rats have revealed that vitamin D deficiency in pregnant dams affects insulin action in the offspring, and this is thought to occur via methylation of the gene encoding nuclear factor κB inhibitor α 50 . Other animal studies have shown that periconceptional supplementation (or deprivation) of choline, folic acid, methionine, or vitamin B 12 can affect the DNA methylation patterns and phenotype of the offspring 51 .…”

Section: Consequences Of Gestational Diabetes For Offspringmentioning

confidence: 99%

Maternal nutrition: opportunities in the prevention of gestational diabetes

2017

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Gestational diabetes mellitus (GDM) is currently defined as glucose intolerance that is of variable severity with onset or first recognition during pregnancy. The Hyperglycemia and Adverse Pregnancy Outcome Study, including 25 000 nondiabetic pregnant women in 15 centers across the world, reported that an average of 17.8% of pregnancies are affected by GDM and its frequency can be as high as 25.5% in some countries, based on the International Association of Diabetes and Pregnancy Study Groups criteria. Nevertheless, true global prevalence estimates of GDM are currently lacking due to the high level of heterogeneity in screening approaches, diagnostic criteria, and differences in the characteristics of the populations that were studied. The presence of systemic high blood glucose levels in pregnancy results in an adverse intrauterine environment, which has been shown to have a negative impact on short- and long-term health outcomes for both the mother and her offspring, including increased risks for the infant to develop obesity and for both mother and child to develop type 2 diabetes mellitus later in life. Epigenetic mechanisms that are directly influenced by environmental factors, including nutrition, may play a key role in shaping these future health risks and may be part of this vicious cycle. This article reviews the burden of GDM and the current evidence that supports maternal nutritional interventions as a promising strategy to break the cycle by addressing risk factors associated with GDM.

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“…Different micronutrient deficiencies such as folate, vitamin A, vitamin B, potassium, iron, and selenium correlated with hypermethylation of tumor suppressor genes, demonstrating a role in cancer [78,79]. Deprivations of vitamin D [80], calcium [81], magnesium [82], and chromium [49] could increase the risk of developing T2DM through promoting aberrant methylation patterns in genes involved in glucose homeostasis, insulin signaling and inflammatory response. Additionally, deficits of selenium [50] and vitamin A were associated with the pathogenesis of CVD by affecting the DNA methylation status of critical genes [52].…”

Section: Diet and Epigenetic Signaturesmentioning

confidence: 99%

Guide for Current Nutrigenetic, Nutrigenomic, and Nutriepigenetic Approaches for Precision Nutrition Involving the Prevention and Management of Chronic Diseases Associated with Obesity

Ramos-López

Milagro

Allayee³

et al. 2017

Lifestyle Genomics

139

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Chronic diseases, including obesity, are major causes of morbidity and mortality in most countries. The adverse impacts of obesity and associated comorbidities on health remain a major concern due to the lack of effective interventions for prevention and management. Precision nutrition is an emerging therapeutic approach that takes into account an individual's genetic and epigenetic information, as well as age, gender, or particular physiopathological status. Advances in genomic sciences are contributing to a better understanding of the role of genetic variants and epigenetic signatures as well as gene expression patterns in the development of diverse chronic conditions, and how they may modify therapeutic responses. This knowledge has led to the search for genetic and epigenetic biomarkers to predict the risk of developing chronic diseases and personalizing their prevention and treatment. Additionally, original nutritional interventions based on nutrients and bioactive dietary compounds that can modify epigenetic marks and gene expression have been implemented. Although caution must be exercised, these scientific insights are paving the way for the design of innovative strategies for the control of chronic diseases accompanying obesity. This document provides a number of examples of the huge potential of understanding nutrigenetic, nutrigenomic, and nutriepigenetic roles in precision nutrition.

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Maternal vitamin D deficiency during pregnancy results in insulin resistance in rat offspring, which is associated with inflammation and Iκbα methylation

Cited by 54 publications

References 33 publications

Soluble ST2 regulation by rhinovirus and 25(OH)-vitamin D3 in the blood of asthmatic children

Soluble ST2 regulation by rhinovirus and 25(OH)-vitamin D3 in the blood of asthmatic children

Maternal nutrition: opportunities in the prevention of gestational diabetes

Guide for Current Nutrigenetic, Nutrigenomic, and Nutriepigenetic Approaches for Precision Nutrition Involving the Prevention and Management of Chronic Diseases Associated with Obesity

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