Maternally and Naturally Acquired Antibody to &lt;i&gt;Mannheimia haemolytica&lt;/i&gt; in Japanese Black Calves

Otomaru, Konosuke; Kubota, Sei; Tokimori, Makiko

doi:10.1292/jvms.13-0262

Cited by 4 publications

(6 citation statements)

References 12 publications

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“…Serum antibodies against P. multocida were detected on enzyme-linked immune sorbent assay (ELISA), which was performed as described in a previous study [16]. Capsular antigens of P. multocida serotype A3 (strain BP165) were dispensed in the wells of a microtiter plate.…”

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confidence: 99%

“…The highest dilution, which showed an optical density higher than 0.4, was used as an antibody titer. Serum antibodies against M. haemolytica were detected on ELISA, which was performed as described in a previous study [15]. M. haemolytica serotype 1 (HL2 strain) was dispensed in the wells of a microtiter plate.…”

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confidence: 99%

“…In Japanese Black calves, Otomaru et al . [15,16,17] reported that the antibody titers against P. multocida , M. haemolytica and H. somni were decreased at around 4, 8, and 4 weeks of age, respectively, because of transmission of maternal antibody titers against them. Therefore, vaccination against P. multocida , M. haemolytica, and H. somni should be performed at around 4, 8, and 4 weeks of age, respectively.…”

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Effect of combined vaccination for Pasteurella multocida, Mannheimia haemolytica, and Histophilus somni to prevent respiratory diseases in young Japanese Black calves in the field

Nagai

Otomaru

Ogawa

et al. 2019

The Journal of Veterinary Medical Science

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To evaluate the preventive effects of combined vaccination for Pasteurella multocida, Mannheimia haemolytica and Histophilus somni on respiratory diseases in Japanese Black calves, 295 calves at one farm were alternately assigned to two groups; 147 calves received the vaccine at 4 and 8 weeks of age (vaccination group), and the other 148 calves did not receive vaccine (control group). The incidences of respiratory diseases were 25.9 and 70.9% in the vaccination and control groups, respectively, and the odds ratio for comparison between the two groups was 0.143 (95% confidence interval: 0.086–0.238). Administration of the multiple vaccine to Japanese black calves might be one of effective factor for prevention of respiratory diseases.

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Effect of combined vaccination for Pasteurella multocida, Mannheimia haemolytica, and Histophilus somni to prevent respiratory diseases in young Japanese Black calves in the field

Nagai

Otomaru

Ogawa

et al. 2019

The Journal of Veterinary Medical Science

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“…Owing to high Ig levels in calves, guaranteeing protection against disease for up to three months and the ability to produce antibodies between 60 and 90 days of life following contact with a pathogen, active immunization can begin at four months, i.e. about 3-4 weeks before weaning (Otomaru et al 2013). Fulton et al (2004) showed that colostral antibodies in calves begin to disappear as early as the first week of life, but the age at which they become undetectable depends on individual and environmental factors, including the quantity of maternal antibodies absorbed by the new-born.…”

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confidence: 99%

“…Analysis of the dynamics of the post-vaccination immune response on particular days in the feedlot revealed that a small level of passive immunity in calves at more than two months of age does not significantly affect the induction of a humoral immune response resulting from immunization with M. haemolytica. The consequence of this is a significant increase in Ig guaranteeing protection against disease (Otomaru et al 2013). Moreover, immunization of calves from two months of age with live modified vaccines stimulates the production of antibodies at a level that ensures protection.…”

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confidence: 99%

The influence of passive colostrum transfer on humoral immunity to selected antigens of Mannheimia haemolytica in calves

et al. 2023

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The aim of the study was to evaluate the effectiveness of colostral immunity against aetiological agents of bovine respiratory disease complex (BRDC), to assess the suppressive effect of colostral antibodies against Mannheimia haemolytica on immunity, and to analyse acute phase proteins in calves. Holstein-Friesian and Simmental cows and calves were immunized with M. haemolytica leukotoxin (Lkt) and outer membrane proteins (OMPs) at 6 and 4 weeks before parturition. Sera and colostrum were collected from the cows directly after calving. Sera from calves were obtained before colostrum intake and 48 h after birth. Calves from vaccinated and unvaccinated cows were placed in the feedlot and immunized with Lkt or OMP on days 10 and 24. Calves were tested for serum antibodies against respiratory viruses. Trachea and lung samples were collected for bacteriological examination from all calves that had died with BRDC. The results indicated high colostrum values and IgG transfer in calves at 48 h (> 12.5 g/l) and a high concentration of anti-BVD antibodies in calves at 48 h (> 33–45 mg/ml). Similar values were observed for bovine herpes virus BHV-1 and bovine respiratory sycytil virus BRSV. Immunoglobulin concentrations were highest for antibodies specific to parainfluenza PI-3 and adenoviruses. The lowest antibody levels were detected against M. haemolytica antigens in all experimental groups of calves (< 50 mg/ml in calves of cows vaccinated with M. haemolytica antigens and < 25 mg/ml in calves of unvaccinated cows). The findings indicate the need for early immunization of calves, which is often precluded by stress associated with transport and adaptation to the new conditions in the feedlot.

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A field study on the effects of inactivated bacteria vaccine for respiratory diseases in Japanese Black calves

Otomaru

Fujimura

Miyahara

et al. 2023

Animal Science Journal

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This study evaluated the effects of vaccination for Pasteurella multocida, Mannheimia haemolytica, and Histophilus somni in young Japanese Black calves at an ordinal farm, where respiratory diseases frequently occur at a young age. In total, 105 calves were divided into the vaccination group (n = 52), which received inactivated combined vaccine at 0 and 2 weeks of age, and the control group (n = 53), which received no vaccine. From both groups, eight calves each were randomly selected to determine the antibody titers. And, the incidence of respiratory disease and medical costs (treatment plus vaccination costs) were recorded for each group from birth to 16 weeks of age. In the vaccination group, the antibody titers against P. multocida, M. haemolytica, and H. somni were significantly higher than those in the control group after 8, 12, and 4 weeks of age, respectively (p < 0.05). The incidence of respiratory disease was significantly lower in the vaccination group compared to the control group (p < 0.01), and the medical costs per calf in the vaccination group were 46.4% lower than in the control group. These results might contribute to establishing an effective vaccination program against respiratory diseases in calves at each farm.

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Maternally and Naturally Acquired Antibody to <i>Mannheimia haemolytica</i> in Japanese Black Calves

Cited by 4 publications

References 12 publications

Effect of combined vaccination for <i>Pasteurella multocida</i>, <i>Mannheimia haemolytica</i>, and <i>Histophilus somni</i> to prevent respiratory diseases in young Japanese Black calves in the field

Effect of combined vaccination for <i>Pasteurella multocida</i>, <i>Mannheimia haemolytica</i>, and <i>Histophilus somni</i> to prevent respiratory diseases in young Japanese Black calves in the field

The influence of passive colostrum transfer on humoral immunity to selected antigens of Mannheimia haemolytica in calves

A field study on the effects of inactivated bacteria vaccine for respiratory diseases in Japanese Black calves

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