2021
DOI: 10.3390/molecules26237310
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Mathematical Analysis of Reaction–Diffusion Equations Modeling the Michaelis–Menten Kinetics in a Micro-Disk Biosensor

Abstract: In this study, we have investigated the mathematical model of an immobilized enzyme system that follows the Michaelis–Menten (MM) kinetics for a micro-disk biosensor. The film reaction model under steady state conditions is transformed into a couple differential equations which are based on dimensionless concentration of hydrogen peroxide with enzyme reaction (H) and substrate (S) within the biosensor. The model is based on a reaction–diffusion equation which contains highly non-linear terms related to MM kine… Show more

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Cited by 13 publications
(8 citation statements)
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“…The Gauss-Newton method is used when the current solution is near to the optimal solution. Some recent applications of the LM algorithm include the solution of an inverse heat conduction problem [49], a system of reaction-diffusion equations in a micro-disk biosensor [50], heat flux estimation [51], energy-gradient fitting [52], charge estimation of lithium-ion batteries [53] and piles embedded in sandy soil [54]. A detailed summary of the working process of a FFNN-BLM algorithm is shown in Figure 4.…”
Section: Learning Proceduresmentioning
confidence: 99%
“…The Gauss-Newton method is used when the current solution is near to the optimal solution. Some recent applications of the LM algorithm include the solution of an inverse heat conduction problem [49], a system of reaction-diffusion equations in a micro-disk biosensor [50], heat flux estimation [51], energy-gradient fitting [52], charge estimation of lithium-ion batteries [53] and piles embedded in sandy soil [54]. A detailed summary of the working process of a FFNN-BLM algorithm is shown in Figure 4.…”
Section: Learning Proceduresmentioning
confidence: 99%
“…Table 4 Statistics of the calculated results for thermal distribution of a wetted porous structure and their corresponding AE obtained by the proposed scheme for variations in velocity parameter (Pe) with N r = N c = 2, = 1 and = 0.4 where NSE is Nash-Sutcliffe Efficiency and is defined as Umar et al (2020); Khan et al (2021a) here Θ and Θ are the approximate and exact solutions for the problem. M corresponds to the total number of mesh (grid) points, and i denotes the number of current solution points.…”
Section: Performance Measuresmentioning
confidence: 99%
“…where ϵ 1 to ϵ 6 are defined as follows: e LeNN-WOA-NM algorithm is used to optimize the population densities of equation (37). Table 33 the prey-predator model is discussed.…”
Section: Problem V: Effect Of Variation In C 1 On the Prey-predatormentioning
confidence: 99%
“…In recent times, artificial neural network (ANN)-based stochastic algorithms with global and local search optimizers have been designed to solve differential equations representing physical phenomena including flow in a circular cylindrical conduit via electrohydrodynamics [36], a model of an immobilized enzyme system that follows the Michaelis-Menten (MM) kinetics for a microdisk biosensor [37], flow of Johnson-Segalman fluid on the surface of an infinitely long vertical cylinder [38], and beam-column designs [39].…”
Section: Introductionmentioning
confidence: 99%