Mathematical Analysis of the Long-Term Efficacy of Daily Home Hemodialysis Therapy with a Cold Dialysate Regeneration System

Abstract

Background/Aim: We previously developed the cold dialysate regeneration system (CDRS) for use in daily home hemodialysis (HD). This study evaluates the long-term efficacy of the CDRS using a mathematical method. Method: HD with the CDRS was simulated using a method that integrates the mass-transfer model and the dialyzer solute kinetics model with a newly proposed model of CDRS function. Results: We mathematically assessed the long-term efficacy of HD with the CDRS. The weekly treatment time required for HD with the CDRS was reduced significantly using the daily dialysis method; it required only an 11% longer treatment time to obtain the corrected equivalent renal clearance and a 14% shorter time for the standard Kt/V, compared with thrice weekly treatment with conventional HD. Conclusion: By developing a mathematical model to test the long-term efficacy of the new CDRS, we showed that HD with the CDRS is an efficient means of daily home hemodialysis therapy.