Mathematical Modeling of Drug Release from Natural Polysaccharides Based Matrices

Chiarappa, Gianluca; Abrami, Michela; Dapas, Barbara; Farra, Rossella; Trebez, Fabio; Musiani, Francesco; Grassi, Gabriele

doi:10.1177/1934578x1701200610

Cited by 7 publications

(8 citation statements)

References 75 publications

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“…In addition, the inverse proportionality between G' and T 2m (see Fig. 9) agrees with what theoretically predicted in the case of gels (Fanesi et al, 2018) when dangling chains do not exist in the network or their fraction is negligible (Chiarappa et al, 2017).…”

Section: Resultssupporting

confidence: 89%

Investigation on the thermal gelation of Chitosan/β-Glycerophosphate solutions

Abrami

Siviello

Grassi³

et al. 2019

Carbohydrate Polymers

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Section: Resultssupporting

confidence: 89%

Investigation on the thermal gelation of Chitosan/β-Glycerophosphate solutions

Abrami

Siviello

Grassi³

et al. 2019

Carbohydrate Polymers

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“…Finally, before looking at several sustained release material systems based on HA and its derivatives, it is acknowledged that design of sustained release systems requires a thorough understanding of mathematical modeling of drug release from polymeric matrices and interactions between drugs and polymers [36]. In general, drug release from hydrogels are modeled to account for both diffusion (Fickian diffusion) and desorption (based on Langmuir kinetics) mechanisms that control the overall release rate.…”

Section: Methodsmentioning

confidence: 99%

Hyaluronic Acid and Controlled Release: A Review

2020

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Hyaluronic acid (HA) also known as hyaluronan, is a natural polysaccharide—an anionic, non-sulfated glycosaminoglycan—commonly found in our bodies. It occurs in the highest concentrations in the eyes and joints. Today HA is used during certain eye surgeries and in the treatment of dry eye disease. It is a remarkable natural lubricant that can be injected into the knee for patients with knee osteoarthritis. HA has also excellent gelling properties due to its capability to bind water very quickly. As such, it is one the most attractive controlled drug release matrices and as such, it is frequently used in various biomedical applications. Due to its reactivity, HA can be cross-linked or conjugated with assorted bio-macromolecules and it can effectively encapsulate several different types of drugs, even at nanoscale. Moreover, the physiological significance of the interactions between HA and its main membrane receptor, CD44 (a cell-surface glycoprotein that modulates cell–cell interactions, cell adhesion and migration), in pathological processes, e.g., cancer, is well recognized and this has resulted in an extensive amount of studies on cancer drug delivery and tumor targeting. HA acts as a therapeutic but also as a tunable matrix for drug release. Thus, this review focuses on controlled or sustained drug release systems assembled from HA and its derivatives. More specifically, recent advances in controlled release of proteins, antiseptics, antibiotics and cancer targeting drugs from HA and its derivatives were reviewed. It was shown that controlled release from HA has many benefits such as optimum drug concentration maintenance, enhanced therapeutic effects, improved efficiency of treatment with less drug, very low or insignificant toxicity and prolonged in vivo release rates.

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“…A first-order fit suggests that the release of VC from the nanocapsules corresponded to the sustained-release and matrix diffusion-controlled release. In contrast, a good fit to the Higuchi model represented a diffusing water-soluble drug in a matrix system, where the square root of time-dependent release is associated with the Fickian diffusion ( Caccavo et al., 2015 ; Chiarappa et al., 2017 ). In summary, the VC release was mediated by diffusion from the GCh matrix, where the VC was electrostatically bound.…”

Section: Resultsmentioning

confidence: 99%

Encapsulation and controlled release of vitamin C in modified cellulose nanocrystal/chitosan nanocapsules

Baek

Ramasamy

Willis

et al. 2021

Current Research in Food Science

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Vitamin C (VC), widely used in food, pharmaceutical and cosmetic products, is susceptible to degradation, and new formulations are necessary to maintain its stability. To address this challenge, VC encapsulation was achieved via electrostatic interaction with glycidyltrimethylammonium chloride (GTMAC)-chitosan (GCh) followed by cross-linking with phosphorylated-cellulose nanocrystals (PCNC) to form VC-GCh-PCNC nanocapsules. The particle size, surface charge, degradation, encapsulation efficiency, cumulative release, free-radical scavenging assay, and antibacterial test were quantified. Additionally, a simulated human gastrointestinal environment was used to assess the efficacy of the encapsulated VC under physiological conditions. Both VC loaded, GCh-PCNC, and GCh-Sodium tripolyphosphate (TPP) nanocapsules were spherical with a diameter of 450 ± 8 and 428 ± 6 nm respectively. VC-GCh-PCNC displayed a higher encapsulation efficiency of 90.3 ± 0.42% and a sustained release over 14 days. The release profiles were fitted to the first-order and Higuchi kinetic models with R 2 values greater than 0.95. VC-GCh-PCNC possessed broad-spectrum antibacterial activity with a minimum inhibition concentration (MIC) of 8–16 μg/mL. These results highlight that modified CNC-based nano-formulations can preserve, protect and control the release of active compounds with improved antioxidant and antibacterial properties for food and nutraceutical applications.

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Mathematical Modeling of Drug Release from Natural Polysaccharides Based Matrices

Cited by 7 publications

References 75 publications

Investigation on the thermal gelation of Chitosan/β-Glycerophosphate solutions

Investigation on the thermal gelation of Chitosan/β-Glycerophosphate solutions

Hyaluronic Acid and Controlled Release: A Review

Encapsulation and controlled release of vitamin C in modified cellulose nanocrystal/chitosan nanocapsules

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