Mathematical Modeling of Drug Release from Microemulsions: Theory in Comparison with Experiments

Mass Transport Properties of Progesterone and Estradiol in Model Microemulsion Formulations

“…Independent experiments were conducted first to characterize the critical physical parameters of the model, including the diffusivity of the steroids in the microemulsion formulations, the silicone rubber-aqueous distribution coefficient of the monomer drug and the oil droplet-aqueous distribution coefficient. Other mass transport models have been proposed (for example, (27)), but the Amidon model has the advantage of employing parameters (such as diffusion coefficient) that may be obtained independently.…”

The mathematical model of insulin desorption from the bioactive, fibrous artificial store

“…Interaction between polymers and insulin has been extensively studied 1, 3, 11. In general, the release of an active fibrous artificial store is determined by the interplay of the following processes: (a) diffusion of the external medium into the fibrous store; (b) relaxation of the fibrous carrier, including swelling; (c) diffusion across the mobile insulin from the bulk of the matrix to its surface; (d) phase transfer; (e) diffusion across the boundary layer.…”

“…A number of mathematical models have been developed, which describe the release kinetics of dispersed solutes,9–16 mainly for one‐dimensional release, in the past decades. Because of mathematical complications, the majority of the models postulate an infinite well‐agitated sink, i.e.…”

Microemulsions - A Brief Introduction

“…The investigation of the drug release from drug loaded microemulsions (Grassi et al, 2000, Sirotti et al, 2002, nanoparticle precipitation using a population balance model (Niemann & Sundmacher, 2010), the formation of nanoparticles in mixing of two microemulsion systems by a Monte Carlo model (Jain & Mehra, 2004), timeevolution of the polymer particle size distribution (Suzuki & Nomura, 2003) and solubilization of oil mixtures in anionic microemulsions (Szekeres et al, 2006) have been perfomed theoretically.…”