The evaluation of structural safety must be taken after each earthquake. The importance losses of life and materials carries the significance of the works in the field of earthquake engineering. The purpose of this study was to optimize and evaluate the earthquake resistance of bridge piers by adopting different cross-section forms and dimensions for bridge supports under earthquake action. Two methods of seismic design were used in the optimization and evaluation process. These methods were demand to capacity ratio (DCR) and yielding point. The results of demand to capacity ratio shown that the values of DCR for all piers forms models were increased when the dimension of pier cross section were increased and the values of DCR became less than 1.0, indicating that the increasing in dimensions leading to rise the capacity of bridge supports to carry the earthquake loads in transverse and longitudinal direction. Comparing with models, solid wall pier form had the lower value of DCR, indicating that solid wall piers were suitable in the design of bridge supports to resist the lateral loads of earthquake and it has enough stiffness and capacity under earthquake action. The results of performance points shown that the yielding points were increased when the dimensions of piers were increased for all piers form in transverse and longitudinal direction. The maximum values were appeared within support No. 1 and support No. 4. Solid wall form of pier had the higher values of yielding points, meaning that this type of piers form had higher seismic capacity and it will resist the earthquake action more than others piers form. This study recommended that to use third model for each pier form in the design of bridges structures to resist the earthquake load. Also this study was recommended to use solid wall piers as supports in construction of bridge structure within areas had earthquake action.