2020
DOI: 10.1101/2020.07.06.190470
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Mathematical Modeling of Retinal Degeneration: Aerobic Glycolysis in a Single Cone

Abstract: ABSTRACTCell degeneration, including that resulting in retinal diseases, is linked to metabolic issues. In the retina, photoreceptor degeneration can result from imbalance in lactate production and consumption as well as disturbances to pyruvate and glucose levels. To identify the key mechanisms in metabolism that may be culprits of this degeneration, we use a nonlinear system of differential equations to mathematically model the metabolic pathway of aerobic glycolysis in a hea… Show more

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Cited by 2 publications
(10 citation statements)
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“…The flow diagram in Figure 1 represents the metabolic pathways model for a single cone (governing equations shown in Appendix A ), which we developed in Camacho et al . (2020) [ 25 ]. Mass-action, Michaelis–Menten kinetics and allosteric regulations were applied to the relevant parts of the variable interactions, following key features of photoreceptor biochemistry [ 2 , 26 , 27 ].…”
Section: Methodsmentioning
confidence: 99%
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“…The flow diagram in Figure 1 represents the metabolic pathways model for a single cone (governing equations shown in Appendix A ), which we developed in Camacho et al . (2020) [ 25 ]. Mass-action, Michaelis–Menten kinetics and allosteric regulations were applied to the relevant parts of the variable interactions, following key features of photoreceptor biochemistry [ 2 , 26 , 27 ].…”
Section: Methodsmentioning
confidence: 99%
“… The diagram was modified from Camacho et al . (2020) [ 25 ] to show interactions of the cone with the RPE and a rod photoreceptor (dashed green arrows). Parameters α and δ used in the cone model are defined as proxies for interactions with the RPE and rods.…”
Section: Methodsmentioning
confidence: 99%
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