Matrix Effects on the Delivery Efficacy of Bifidobacterium animalis subsp.
            <i>lactis</i>
            BB-12 on Fecal Microbiota, Gut Transit Time, and Short-Chain Fatty Acids in Healthy Young Adults

Ba, Zhaoyong; Lee, Yujin; Meng, Huicui; Kris-Etherton, Penny M.; Rogers, Connie J.; Lewis, Zachery T.; Mills, David A.; Furumoto, Emily J.; Rolon, M. Laura; Fleming, Jennifer; Roberts, Robert F.

doi:10.1128/msphere.00084-21

Cited by 15 publications

(7 citation statements)

References 76 publications

(90 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This could suggest a potential mechanism of action. A recent study was, however, not able to replicate the effect on intestinal transit time ( 115 ); most likely because of the small number of subjects and that subjects were not selected to have long transit times or be constipated. Consumption of yogurt or a capsule with the strain was not found to change the intestinal microbiota, this is not unusual; the resilience of a healthy colonic microbiota is likely to resist change from one (probiotic) strain ( 116 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Bifidobacterium animalis subsp. lactis HN019 Effects on Gut Health: A Review

Cheng¹,

Laitila²,

Ouwehand³

2021

Front. Nutr.

View full text Add to dashboard Cite

Optimal gut motility is central to bowel function and gut health. The link between the gut dysmotility related disorders and dysfunctional-intestinal barriers has led to a hypothesis that certain probiotics could help in normalizing gut motility and maintain gut health. This review investigates the roles of Bifidobacterium animalis subsp. lactis HN019 (B. lactis HN019™) on gut health, and its mechanisms of action in various pre-clinical and clinical studies. Research supports the hypothesis that B. lactis HN019™ has a beneficial role in maintaining intestinal barrier function during gastrointestinal infections by competing and excluding potential pathogens via different mechanisms; maintaining normal tight junction function in vitro; and regulating host immune defense toward pathogens in both in vitro and human studies. This has been observed to lead to reduced incidence of diarrhea. Interestingly, B. lactis HN019™ also supports normal physiological function in immunosenescent elderly and competes and excludes potential pathogens. Furthermore, B. lactis HN019™ reduced intestinal transit time and increased bowel movement frequency in functional constipation, potentially by modulating gut–brain–microbiota axis, mainly via serotonin signaling pathway, through short chain fatty acids derived from microbial fermentation. B. lactis HN019™ is thus a probiotic that can contribute to relieving gut dysmotility related disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Consumption of yogurt or a capsule with the strain was not found to change the intestinal microbiota, this is not unusual; the resilience of a healthy colonic microbiota is likely to resist change from one (probiotic) strain ( 116 ). However, consumption of the probiotic yogurt did lead to fecal recovery of the strain ( 115 ).…”

Section: Discussionmentioning

confidence: 99%

Bifidobacterium animalis subsp. lactis HN019 Effects on Gut Health: A Review

Cheng¹,

Laitila²,

Ouwehand³

2021

Front. Nutr.

View full text Add to dashboard Cite

show abstract

“…Studies have shown that probiotics can use prebiotics as carbon and energy sources through glycoside hydrolases (GHs). 21,22 CAZy analysis with whole genome sequencing revealed that L. reuteri C501 contains endo-inulinase (EC 3.2.1.7) and exo-inulinase (EC 3.2.1.80), and the glycoside hydrolases of GH32 were involved in the hydrolysis of prebiotic inulin; and L. reuteri C501 was found to use exo-beta-1,3-glucanase (EC 3.2.1.58) and endo-beta-1,3-glucanase (EC 3.2.1.39) of GH55, and endo-1,3(4)-beta-glucanase (EC 3.2.1.6) glycoside hydrolases of GH16 to hydrolyze the prebiotic β-glucan.…”

Section: Resultsmentioning

confidence: 99%

A synbiotic formulation of Lactobacillus reuteri and inulin alleviates ASD-like behaviors in a mouse model: the mediating role of the gut–brain axis

Wang,

Chen,

Jiang

et al. 2024

Food Funct.

View full text Add to dashboard Cite

show abstract

“…lactis BB-12 and L. acidophilus LA-5 ( 81 ) or B. animalis subsp. lactis BB-12 isolated ( 82 ), the use of cheese as a probiotic matrix was shown to be less effective in the adhesion of the probiotic strain to the GI tract ( 83 ). Thus, further RCTs are needed to assess whether there is a difference between probiotic matrices and whether there is a difference between the content where the probiotic capsules or sachets will be dissolved for consumption.…”

Section: Resultsmentioning

confidence: 99%

Probiotics, prebiotics, and synbiotics in chronic constipation: Outstanding aspects to be considered for the current evidence

Araújo

Botelho

2022

Front. Nutr.

View full text Add to dashboard Cite

This integrative aimed to evaluate the effects and the potential mechanism of action of prebiotics, probiotics, and synbiotics on constipation-associated gastrointestinal symptoms and to identify issues that still need to be answered. A literature search was performed in the PubMed database. Animal models (n = 23) and clinical trials (n = 39) were included. In animal studies, prebiotic, probiotic, and synbiotic supplementation showed a decreased colonic transit time (CTT) and an increase in the number and water content of feces. In humans, inulin is shown to be the most promising prebiotic, while B. lactis and L. casei Shirota probiotics were shown to increase defecation frequency, the latter strain being more effective in improving stool consistency and constipation symptoms. Overall, synbiotics seem to reduce CTT, increase defecation frequency, and improve stool consistency with a controversial effect on the improvement of constipation symptoms. Moreover, some aspects of probiotic use in constipation-related outcomes remain unanswered, such as the best dose, duration, time of consumption (before, during, or after meals), and matrices, as well as their effect and mechanisms on the regulation of inflammation in patients with constipation, on polymorphisms associated with constipation, and on the management of constipation via 5-HT. Thus, more high-quality randomized control trials (RCTs) evaluating these lacking aspects are necessary to provide safe conclusions about their effectiveness in managing intestinal constipation.

show abstract

Matrix Effects on the Delivery Efficacy of Bifidobacterium animalis subsp. lactis BB-12 on Fecal Microbiota, Gut Transit Time, and Short-Chain Fatty Acids in Healthy Young Adults

Abstract: Bifidobacterium animalis subsp. lactis BB-12 is a probiotic strain that has been used worldwide since 1985. It has commonly been delivered in fermented dairy products for perceived benefits associated with gut health and enhanced immune function.

Cited by 15 publications

References 76 publications

Bifidobacterium animalis subsp. lactis HN019 Effects on Gut Health: A Review

Bifidobacterium animalis subsp. lactis HN019 Effects on Gut Health: A Review

A synbiotic formulation of Lactobacillus reuteri and inulin alleviates ASD-like behaviors in a mouse model: the mediating role of the gut–brain axis

Probiotics, prebiotics, and synbiotics in chronic constipation: Outstanding aspects to be considered for the current evidence

Contact Info

Product

Resources

About