Matrix metalloproteinase-1 and matrix metalloproteinase-12 gene polymorphisms and the outcome of coronary artery disease

Jguirim-Souissi, Imen; Jelassi, Awatef; Slimani, Afef; Addad, Faouzi; Hassine, M. Oueslati Belhaj; Hamda, Khaldoun Ben; Najah, Mohamed; Maatouk, Faouzi; Rouis, Mustapha; Slimane, Mohamed Naceur

doi:10.1097/mca.0b013e3283478d40

Cited by 13 publications

(5 citation statements)

References 20 publications

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“…Out of 59 qualified studies, 28 studies included Caucasians,8 10 18 20 24 27–29 32 35 37 39 41 43–45 49–51 55 56 21 studies included East Asians,11 17 21 22 25 26 31 33 34 38 42 47 48 53 54 57–59 eight studies included Middle Easterns,9 15 16 23 30 40 46 and two studies included mixed populations 19 36. There were 15 studies involving patients and controls matched on age 9 15 16 29 33 36 39 44 48 56 58.…”

Section: Resultsmentioning

confidence: 99%

Matrix metalloproteinase family gene polymorphisms and risk for coronary artery disease: systematic review and meta-analysis

Niu

2012

Heart

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Section: Resultsmentioning

confidence: 99%

Matrix metalloproteinase family gene polymorphisms and risk for coronary artery disease: systematic review and meta-analysis

Niu

2012

Heart

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“…Although MMP-1 colocalizes with MMP-13 in the shoulder regions of inflamed human atheromatous plaques and that specific MMP-1 haplotypes associate with plaque burden, its direct role in atherosclerosis remains unclear. 7, 31–33 Macrophage-specific transgenic mice expressing human MMP-1 had less advanced atherosclerosis, but overexpression of human tissue inhibitor of metalloproteinase-1 (TIMP-1, an inhibitor of collagenases and other MMPs) showed a tendency to reduce atherosclerotic lesions in apoE −/− mice. 34 …”

Section: Discussionmentioning

confidence: 99%

Matrix Metalloproteinase-13 Predominates Over Matrix Metalloproteinase-8 as the Functional Interstitial Collagenase in Mouse Atheromata

Quillard

Araújo

Franck

et al. 2014

ATVB

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Objective Substantial evidence implicates interstitial collagenases of the MMP family in plaque rupture and fatal thrombosis. Understanding the compensatory mechanisms that may influence the expression of these enzymes and their functions therefore have important clinical implications. This study assessed in mice the unknown relative impact of the two principal collagenases on collagen content and other plaque characteristics. Approach and Results apoE−/− mice, MMP-13−/− apoE−/−, MMP-8−/− apoE−/− double knockout (DKO) mice, and MMP-13−/− MMP-8−/− apoE−/− triple knockout (TKO) mice consumed a high-cholesterol diet for 10 and 24 weeks. Both DKO and TKO mice showed comparable atherosclerotic lesion formation compared to apoE−/− controls. Analysis of aortic root sections indicated that lesions of MMP-8/MMP-13-deficient and MMP-13-deficient mice accumulate more fibrillar collagen than apoE−/− controls and MMP-8−/− apoE−/− DKO. We further tested the relative impact of MMPs on plaque collagenolysis using in situ zymography. MMP-13 deletion alone abrogated collagenolytic activity in lesions, indicating a predominant role for MMP-13 in this process. MMP-13 and MMP-13/MMP-8 deficiency did not alter macrophage content, but associated with reduced accumulation of smooth-muscle cells. Conclusions These results show that among MMP interstitial collagenases in mice, MMP-13 prevails over MMP-8 in collagen degradation in atheromata. These findings provide a rationale for the identification and selective targeting a predominant collagenase for modulating key aspects of plaque structure considered critical in clinical complications, although they do not translate directly to human lesions, which also contain MMP-1.

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“…Another study confirmed that MMP-7 was positively associated with carotid calcification 34. Furthermore, a study investigated haplotypes of MMP-1 and MMP-12 toward prediction of future clinical events in patients with coronary artery disease 38. This study found a trend for predicting events and prognosis, but it did not reach statistical significance due to low sample size.…”

Section: Mmp Polymorphisms and Susceptibility To Diseasementioning

confidence: 93%

Matrix metalloproteinases in atherosclerosis: role of nitric oxide, hydrogen sulfide, homocysteine, and polymorphisms

Vacek

Rehman

Neamtu

et al. 2015

VHRM

121

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Atherosclerosis is an inflammatory process that involves activation of matrix metalloproteinases (MMPs); MMPs degrade collagen and allow for smooth-muscle cell migration within a vessel. Moreover, this begets an accumulation of other cellular material, resulting in occlusion of the vessel and ischemic events to tissues in need of nutrients. Homocysteine has been shown to activate MMPs via an increase in oxidative stress and acting as a signaling molecule on receptors like the peroxisome proliferator activated receptor-γ and N-methyl-D-aspartate receptor. Nitric oxide has been shown to be beneficial in some cases of deactivating MMPs. However, in other cases, it has been shown to be harmful. Further studies are warranted on the scenarios that are beneficial versus destructive. Hydrogen sulfide (H2S) has been shown to decrease MMP activities in all cases in the literature by acting as an antioxidant and vasodilator. Various MMP-knockout and gene-silencing models have been used to determine the function of the many different MMPs. This has allowed us to discern the role that each MMP has in promoting or alleviating pathological conditions. Furthermore, there has been some study into the MMP polymorphisms that exist in the population. The purpose of this review is to examine the role of MMPs and their polymorphisms on the development of atherosclerosis, with emphasis placed on pathways that involve nitric oxide, hydrogen sulfide, and homocysteine.

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Matrix metalloproteinase-1 and matrix metalloproteinase-12 gene polymorphisms and the outcome of coronary artery disease

Cited by 13 publications

References 20 publications

Matrix metalloproteinase family gene polymorphisms and risk for coronary artery disease: systematic review and meta-analysis

Matrix metalloproteinase family gene polymorphisms and risk for coronary artery disease: systematic review and meta-analysis

Matrix Metalloproteinase-13 Predominates Over Matrix Metalloproteinase-8 as the Functional Interstitial Collagenase in Mouse Atheromata

Matrix metalloproteinases in atherosclerosis: role of nitric oxide, hydrogen sulfide, homocysteine, and polymorphisms

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