Matrix metalloproteinase‐1 is associated with poor prognosis in oesophageal cancer

Polymorphisms of matrix metalloproteinase-7 and chymase are associated with susceptibility to and progression of gastric cancer in Japan

“…23,26,[45][46][47][48] Gastric cancer patients who carry the G variant of MMP-7-181 showed worse survival than those with the AA genotype. 48 We found a signifi cant association between this polymorphism and clinicopathological features.…”

A single nucleotide polymorphism in the MMP-1 promoter is correlated with histological differentiation of gastric cancer

“…Several MMPs, including MMP-1, have been reported to play an important role in cancer invasion through their overexpression, which is associated with metastasis and unfavorable prognosis in esophageal cancer, ovarian cancer, cutaneous malignant melanoma, and colorectal cancer (Ghilardi et al 2001;Kanamori et al 1999;Murray et al 1998b;Ye et al 2001). Kanamori et al (1999) observed a high expression level of the MMP-1 in tumors carrying 2G allele than 1G homozygotes in ovarian cancers; however, in this study, 1G/2G polymorphism in the MMP-1 promoter was not associated with invasion, lymph node metastasis, and TNM classification in gastric cancer patients.…”

“…A prognostic value of MMPs expression in tumor tissue has been reported (McDonnel and Matrisian 1991). Overexpression of MMP-1 has been demonstrated in a variety of cancers (Hewitt et al 1991;Murray et al 1998a;Templeton et al 1990), and the expression of MMP-1 is associated with poor prognosis of esophageal cancer patients (Murray et al 1998b). In colorectal cancer, the expression of MMP-1 correlated with pathological factors such as Dukes' stage, differentiation, lymphatic or vascular invasion, and tumor depth (Baker and Leaper 2003).…”

Novel Therapeutics in Colorectal Cancer

“…To better explore the potential role for MMP inhibitors in colorectal cancer, those MMPs overexpressed in large percentages of colorectal cancers (MMP-1, -2, -7, and -9) may need to be targeted specifically. [131][132][133] However, the overlapping substrate specificity of the MMPs may be a factor contributing to the lack of efficacy currently being seen.…”