2010
DOI: 10.3892/or_00000821
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Matrix metalloproteinase-2 and -9 in the urine of prostate cancer patients

Abstract: Abstract. The matrix metalloproteinase family of enzymes is comprised of critically important extracellular proteases whose activity has been implicated in a number of key normal and pathological processes. The latter include growth, progression and metastasis as well as dysregulated angiogenesis that is associated with these events. The MMPs are secreted by all types of cells, and they also carve through the extracellular matrix, allowing cancer cells to take root and metastasize. Endogenous inhibitors typica… Show more

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Cited by 9 publications
(4 citation statements)
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“…Thus, they are commonly used as serum markers of the malignant phenotype. 10 Another protein family that linked to EMT is the cadherin family, which include E-cadherin, N-cadherin, etc. More and more studies have proved that PRRX1 can regulate cadherin family to directly regulate the occurrence or process of EMT through the Wnt/β-catenin signaling pathway and/or Notch signaling pathway ( Figure 1 ).…”
Section: Prrx1 Promotes Emt Of Tumor Cellsmentioning
confidence: 99%
“…Thus, they are commonly used as serum markers of the malignant phenotype. 10 Another protein family that linked to EMT is the cadherin family, which include E-cadherin, N-cadherin, etc. More and more studies have proved that PRRX1 can regulate cadherin family to directly regulate the occurrence or process of EMT through the Wnt/β-catenin signaling pathway and/or Notch signaling pathway ( Figure 1 ).…”
Section: Prrx1 Promotes Emt Of Tumor Cellsmentioning
confidence: 99%
“…More experiments will be carried out in the future to further investigate the effect of FOXD1-AS1 on PCa chemoresistance. Furthermore, members of matrix metalloproteinase (MMPs) family are related to biological processes, such as cell growth, differentiation, invasion, migration, apoptosis, tumour angiogenesis and immune surveillance in cancer development (Di Carlo et al, 2010). MMP2 and MMP9 are most closely related to tumour aggressiveness and overall survival, which are prevalently regarded as serum markers of malignant phenotypes (Di Carlo et al, 2010).…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, members of matrix metalloproteinase (MMPs) family are related to biological processes, such as cell growth, differentiation, invasion, migration, apoptosis, tumour angiogenesis and immune surveillance in cancer development (Di Carlo et al, 2010). MMP2 and MMP9 are most closely related to tumour aggressiveness and overall survival, which are prevalently regarded as serum markers of malignant phenotypes (Di Carlo et al, 2010). Increased levels of MMP2 and MMP9 in the plasma and urine have been verified to be associated with metastasis in patients with prostate cancer (Zhang et al, 2004).…”
Section: Discussionmentioning
confidence: 99%
“…Multiple publications have identified an increased expression in PrCa [59,61,78,83,109,113,129,153,156], including positive associations with more advanced PrCa [67,75,84,103] [92,102] and poorer prognosis [35,77,89]. Others show no association [24,47,48,52,118], and a small number show negative associations [25,31,40] with PrCa progression, indicating that MMP-9 is not universally important. However, functional studies serve to confirm its significant role, particularly in PrCa spreading, with MMP-9 ablation repeatedly shown to decrease its invasion and/or migration [57,87,100,148].…”
Section: Soluble Matrix Metalloproteinases (Mmps)mentioning
confidence: 99%