Matrix metalloproteinase-8 is the major potential collagenase in active peri-implantitis

Arakawa, Hikaru; Uehara, Junji; Hara, Emilio Satoshi; Sonoyama, Wataru; Kimura, Aya Hirata; Kanyama, Manabu; Matsuka, Yoshizo; Kuboki, Takuo

doi:10.1016/j.jpor.2012.07.002

Cited by 60 publications

(60 citation statements)

References 35 publications

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“…In contrast, MMP-1 levels were much lower than MMP-8 levels in the PISF. This study was corroborated by Arakawa et al, 24 who looked at MMP-1, MMP-8, and MMP-13, and found MMP-8 to be the major collagenase present in PISF of active peri-implantitis sites. Another group concluded that MMP-8 levels in PISF may be useful for monitoring the progression of periimplant disease, as an increase of MMP-8 levels may be an early sign of inflammation.…”

Section: Matrix Metalloproteinasessupporting

confidence: 77%

Biomarkers Associated With Periimplant Diseases

Li¹,

Wang²

2014

Implant Dentistry

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Section: Matrix Metalloproteinasessupporting

confidence: 77%

Biomarkers Associated With Periimplant Diseases

Li¹,

Wang²

2014

Implant Dentistry

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“…Their involvement in peri-implant tissue destruction has also received attention, and a number of studies have demonstrated that MMP levels in PICF from periimplantitis sites are elevated compared to healthy sites, and that their enzymatic activity increases with disease severity (Kivela-Rajamaki et al 2003a;Kivela-Rajamaki et al 2003b;Ozcakir-Tomruk et al 2012;Xu et al 2008;Teronen et al 1997), while successful treatment results in reduction (Wohlfahrt et al 2014;Salvi et al 2012). Moreover, studies to determine whether MMP-8 is useful prognostic marker of peri-implantitis, have shown that sites higher high PICF levels of MMP-8 are at greater risk for progressive bone loss (Arakawa et al 2012).…”

mentioning

confidence: 99%

Peri-Implant Infections of Oral Biofilm Etiology

Belibasakis

Charalampakis

Bostancı

et al. 2014

Advances in Experimental Medicine and Biology

108

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Biofilms are complex microbial communities that grow on various surfaces in nature. The oral micobiota tend to form polymicrobial biofilms, particularly on the hard mineralized surfaces of teeth, which may impact on oral health and disease. They can cause inflammation of the adjacent tooth-supporting (periodontal) tissues, leading to destructive periodontal disease and tooth loss. The emergence of osseointegrated dental implants as a restorative treatment option for replacing missing teeth has also brought along new artificial surfaces within the oral cavity, on which oral bacteria can form biofilms. As in the case of natural teeth, biofilms on implant surfaces may also trigger infection and cause inflammatory destruction of the peri-implant tissue (i.e. peri-implantitis). While there are strong similarities in the composition of the mixed microbial flora between periodontal and peri-implant infections, there are also a few distinctive differences. The immunological events underlying the pathogenesis of peri-implant infections are qualitatively similar, yet more extensive, compared to periodontal infections, resulting in a faster progression of tissue destruction. This chapter summarizes the current knowledge on the microbiology and immunology of peri-implant infections, including findings from the peri-implant crevicular fluid, the inflammatory exudate of the peri-implant tissue. Moreover, it discusses the diagnosis and current approaches for the treatment of oral infections.

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“…A capacidade de decompor o colágeno sem afetar as propriedades de outras proteínas, tornou a colagenase uma ferramenta aplicável nas ciências médicas para limpar feridas necrosadas, escaras, cicatrizes pós-operatórias, em queimaduras, no tratamento de psoríase e pediculoses, em casos de implantes e perdas ósseas, em casos de lesões de mamilos de mulheres em aleitamento, no tratamento de cicatrizes hipertróficas, no tratamento de fibroma uterino, de isquemias do coração, de glaucoma, no reparo de cartilagem, de queloides, no de hérnia de disco intervertebral, no da celulite, no debridamento de úlceras de pessoas diabéticas e na regeneração dos tecidos da pele (Takahashi et al, 1999, Özcan et al, 2002, Watanabe, 2004, Arakawa et al, 2012, Alipour et al, 2016, Tallis et al, 2013, Brunengraber et al, 2014, Chandika et al, 2015.…”

Section: Aplicações Na Indústria Biomédica E Terapêuticaunclassified

Colagenasas do pescado y sus aplicaciones industriales

Oliveira

Cunha

Assis

et al. 2017

Pubvet

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RESUMO.Colagenases são grupos de enzimas capazes de clivar a tripla-hélice do colágeno não tendo ação sobre outro tipo de proteína. São obtidas a partir de uma vasta gama de fontes, tais como tecido animal e vegetal. Uma fonte promissora na atualidade é a partir de resíduos negligenciados do processamento do pescado, tais como vísceras internas (intestino). Esta revisão objetivou realizar um levantamento quantitativo da produção cientifica relacionada à colagenase do pescado, bem como dissertar sobre as principais características bioquímicas e aplicações industriais dessa protease, com ênfase nas colagenases extraídas a partir de organismos aquáticos. Dessa forma, através de análise do Scopus, no período de 1963 a 2016, foram detectadas 274 citações ao termo "collagenase fish". A produção cientifica pertinente a colagenase do pescado está intrinsicamente relacionada a necessidade industrial de fontes alternativas dessas proteases colagenolíticas, devido sua extensa aplicação industrial, tais como nos segmentos alimentícios, biomédicos, terapêuticos e têxtil.Palavras chave: Biotecnologia, enzimas, pescado, protease, resíduos Fish collagenases and its industrial applicationsABSTRACT. Collagenases are a group of enzymes capable of cleaving the triple-helix collagen, having no action on another type of protein. They are obtained from a wide range of sources, such as animal and plant tissue. A promising source at present is from neglected fish processing residues, such as internal viscera (intestine). This review aimed to quantify the scientific production related to fish collagenase, as well as to discuss the main biochemical characteristics and industrial applications of this protease, with emphasis on collagenases extracted from aquatic organisms. Thus, through analysis of Scopus, from 1963 to 2016, 274 citations were detected to the term "collagenase fish". The scientific production relevant to fish collagenase is intrinsically related to the industrial need for alternative sources of these collagenolytic proteases, due to their extensive industrial application, such as in the food, biomedical, therapeutic and textile segments.

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Matrix metalloproteinase-8 is the major potential collagenase in active peri-implantitis

Abstract: This study showed MMP-8 as a possible marker for progressive bone loss in peri-implantitis.

Cited by 60 publications

References 35 publications

Biomarkers Associated With Periimplant Diseases

Biomarkers Associated With Periimplant Diseases

Peri-Implant Infections of Oral Biofilm Etiology

Colagenasas do pescado y sus aplicaciones industriales

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