Matrix metalloproteinase‐9, 10, and stress hyperglycaemia in acute kidney injury

Guvercin, Guray; Karakuş, Volkan; Akşit, Murat; Dere, Yelda; Aktar, Merve; Alpay, Hasan; Bozkaya, Giray; Tatar, Erhan

doi:10.1111/eci.12963

Cited by 8 publications

(4 citation statements)

References 31 publications

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“…By contrast, Wang et al [ 8 ] reported that among non-diabetic patients with stress hyperglycemia and AKI, glucose levels correlated with urinary N-acetyl-β-D-glucosaminidase (uNAG), which is another marker of tubular injury. Guvercin et al [ 9 ] found that serum matrix metalloproteinase (MMP)-9 levels were associated with the need for dialysis and with mortality among non-diabetic geriatric patients with stress hyperglycemia and AKI. Moriyama et al reported that hyperglycemia upon admission was found to be an independent predictor of AKI among 664 Japanese patients presented with acute myocardial infarction (AMI), a third of them, only, with diabetes [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…Thus, hyperglycemia, irrespective to diabetes, may foresee the risk of AKI in patients presented with severe acute illness, as shown, for instance, in patients with COVID-19 disease [ 6 ]. Yet, while the impact of hyperglycemia upon admission on mortality has been thoroughly studied [ 7 ], data are limited regarding renal outcome [ 8 , 9 , 10 ], other than in the setup of acute myocardial infarction and coronary interventions [ 11 , 12 , 13 , 14 ]. Nevertheless, KDIGO guidelines suggest a correction of hyperglycemia among measures aimed at reducing AKI, for example in perioperative settings [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Hyperglycemia on Admission Predicts Acute Kidney Failure and Renal Functional Recovery among Inpatients

Gorelik

Bloch-Isenberg

Hashoul

et al. 2021

JCM

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Background: Hyperglycemia is associated with adverse outcomes in hospitalized patients. We aimed to assess the impact of glucose levels upon admission on the subsequent deterioration or improvement of kidney function in inpatients with a focus on diabetes or reduced baseline kidney function as possible modifiers of this effect. Methods: Running a retrospective cohort analysis, we compared patients with normal vs. high glucose levels upon admission. We applied multivariable logistic regression models to study the association between baseline glucose levels with subsequent renal and clinical outcomes. Interaction terms were used to study a possible modifier effect of diabetes. Results: Among 95,556 inpatients (52% males, mean age 61 years), 15,675 (16.5%) had plasma glucose higher than 180 mg/dL, and 72% of them were diabetics. Patients with higher glucose at presentation were older, with a higher proportion of co-morbid conditions. Rates of acute kidney injury (AKI), acute kidney functional recovery (AKR), and mortality were proportional to reduced renal function. AKI, AKR, and mortality were almost doubled in patients with high baseline glucose upon admission. Multivariable analysis with interaction terms demonstrated an increasing adjusted probability of all events as glucose increased, yet this association was observed principally in non-diabetic patients. Conclusions: Hyperglycemia is associated with AKI, AKR, and mortality in non-diabetic inpatients in proportion to the severity of their acute illness. This association diminishes in diabetic patients, suggesting a possible impact of treatable and easily reversible renal derangement in this population.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hyperglycemia on Admission Predicts Acute Kidney Failure and Renal Functional Recovery among Inpatients

Gorelik

Bloch-Isenberg

Hashoul

et al. 2021

JCM

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“…MMP-10 was reported to be associated with atherosclerosis (Purroy et al , 2018), intracerebral hemorrhage (Howe et al , 2018), pulmonary hypertension (Avouac et al , 2017), and cancers (Miyata et al , 2007; Du et al , 2014; Kadeh et al , 2016; Juchniewicz et al , 2017). Recently, Guvercin et al reported that the increase of serum MMP-10 is related to acute kidney injury in nondiabetic geriatric patients (Guvercin et al , 2018). Our data demonstrated that the expression of MMP-10 in normal kidney tissues is very weak, but could be strongly activated by IRI treatment, supporting that MMP-10 is a potential candidate involved in renal IRI.…”

Section: Discussionmentioning

confidence: 99%

Identification of Candidate Genes Involved in Renal Ischemia/Reperfusion Injury

Lin

et al. 2019

DNA and Cell Biology

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Renal ischemia/reperfusion injury (IRI) is a main risk factor for the occurrence of delayed graft function or primary graft nonfunction of kidney transplantation. However, it lacks ideal molecular markers for indicating IRI in kidney transplantation. The present study is to explore novel candidate genes involved in renal IRI. Experimental renal IRI mouse models were constructed, and the differentially expressed genes were screened using a microarray assay. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis were performed. The expression of genes was detected using real-time qPCR assay. Western blotting and immunohistochemistry staining assays were performed for protein determination. We identified that renal IRI induced the upregulation of SPRR2F, SPRR1A, MMP-10, and long noncoding RNA (lncRNA) Malat1 in kidney tissues for 479.3-, 4.98-, 238.1-, and 3.79-fold, respectively. The expression of miR-139-5p in kidney tissues of IRI-treated mice was decreased to 40.4% compared with the sham-operated mice. These genes are associated with keratinocyte differentiation, regeneration and repair of kidney tissues, extracellular matrix degradation and remodeling, inflammation, and cell proliferation in renal IRI. Identification of novel biomarkers involved in renal IRI may provide evidences for the diagnosis and treatment of renal IRI.

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“…However, suitable time of initiating RRT remains controversial. There is a study showing that serum MMP-10 levels serve as an important predictor of the necessity of emergency RRT in nondiabetic geriatric patients with AKI [62]. Nevertheless, because of the limited number of patients in this study, careful follow-up evaluation with a larger sample size is needed to confirm this finding.…”

Section: Acute Kidney Injurymentioning

confidence: 72%

Matrix Metalloproteinase-10 in Kidney Injury Repair and Disease

Sun

Liu

2022

IJMS

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Matrix metalloproteinase-10 (MMP-10) is a zinc-dependent endopeptidase with the ability to degrade a broad spectrum of extracellular matrices and other protein substrates. The expression of MMP-10 is induced in acute kidney injury (AKI) and chronic kidney disease (CKD), as well as in renal cell carcinoma (RCC). During the different stages of kidney injury, MMP-10 may exert distinct functions by cleaving various bioactive substrates including heparin-binding epidermal growth factor (HB-EGF), zonula occludens-1 (ZO-1), and pro-MMP-1, -7, -8, -9, -10, -13. Functionally, MMP-10 is reno-protective in AKI by promoting HB-EGF-mediated tubular repair and regeneration, whereas it aggravates podocyte dysfunction and proteinuria by disrupting glomerular filtration integrity via degrading ZO-1. MMP-10 is also involved in cancerous invasion and emerges as a promising therapeutic target in patients with RCC. As a secreted protein, MMP-10 could be detected in the circulation and presents an inverse correlation with renal function. Due to the structural similarities between MMP-10 and the other MMPs, development of specific inhibitors targeting MMP-10 is challenging. In this review, we summarize our current understanding of the role of MMP-10 in kidney diseases and discuss the potential mechanisms of its actions.

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Matrix metalloproteinase‐9, 10, and stress hyperglycaemia in acute kidney injury

Abstract: Stress hyperglycaemia is a common condition among nondiabetic geriatric patients with AKI and is related to mortality. Serum MMP-10 levels serve as an important predictor of the necessity of emergency RRT in these patients.

Cited by 8 publications

References 31 publications

Hyperglycemia on Admission Predicts Acute Kidney Failure and Renal Functional Recovery among Inpatients

Hyperglycemia on Admission Predicts Acute Kidney Failure and Renal Functional Recovery among Inpatients

Identification of Candidate Genes Involved in Renal Ischemia/Reperfusion Injury

Matrix Metalloproteinase-10 in Kidney Injury Repair and Disease

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