Matrix Metalloproteinase 9 and Vasodilator-Stimulated Phosphoprotein Related to Acute Kidney Injury in Severe Acute Pancreatitis Rats

Abstract

In the presence of acute kidney injury in SAP, the renal expression of MMP-9 and VASP is related to damage of endothelial cells in capillaries, which reached a maximum at 24 h and declined afterwards.

Association of Matrix Metalloproteinases -7, -8 and -9 and TIMP -1 with Disease Severity in Acute Pancreatitis. A Cohort Study

“…In a recent rodent study on experimental SAP MMP-9 was found to be substantially elevated in the kidney within 12 h of the induction of pancreatitis preceding a later rise in serum creatinine [27]. We assessed MMP-9 in plasma, but found no correlation with plasma creatinine.…”

“…The concentration of MMP-8 in serum has been shown to be elevated in septic children with AKI compared to those without AKI [26], but less is known about the relationship between MMP-8 and AKI in AP. In a recent rodent study on experimental SAP, MMP-9 was found to be markedly elevated in the kidney within 12 h from the induction of pancreatitis preceding a later rise in serum creatinine [27]. In humans the association of MMPs to organ failure in patients with AP is poorly investigated.…”

Potential Prognostic Markers of Acute Kidney Injury in the Early Phase of Acute Pancreatitis

“…TIMP-2, as an inhibitor of extracellular matrix metalloproteinases (MMPs), was mostly studied in the context of chronic pancreatitis, where MMPs are implicated in extracellular matrix remodeling and pancreatic fibrosis [75,76]. Matrix metalloproteinase-9 (MMP-9) was implicated in renal injury in SAP: MMP-9 seems to be involved in renal capillary injury and leakage, as its expression in kidneys preceded the histological signs of renal injury [37] (see Table 2). Additionally, earlier works have shown the pathophysiological role of MMP-9, being released by activated neutrophils, in gut-barrier disruption and organ failure in SAP [77,78].…”

“…Additionally, sFlt-1 significantly predicted renal failure in the first two days of AP [67] (Table 3). Increased expression of a protein that is associated with remodeling of endothelial cells’ cytoskeleton and junctions, vasodilator-stimulated phosphoprotein (VASP) was observed in kidneys of rats with AP [37]. VASP expression seemed involved in pathophysiology of AKI complicating AP, as its maximum preceded the maximum histological changes that are associated with renal failure [37] (Table 2).…”

Peculiarities of Inflammation, Oxidative/Nitrosative Stress in L-Ornithine-Induced Acute Pancreatitis

“…Проте знач ні досягнення в галузі фундаментальних досліджень в останнє десятиріччя збагатили відомості про пато фізіолоґічні процеси в разі захворювання на ГП. Ци токіни [20], вільні радикали оксиґену та нітроґену [3], Ca 2+ [21], стрес ендоплазматичного ретикулуму [27], нейтрофіли [18], автофаґія [28], DAMP (pathogen associated molecular pattern) [12], металопротеїнази [17], адипокіни [15], ядерний фактор NFκB [14], мо лекули адгезії [13], мітохондріальна дисфункція [8], ішемія підшлункової залози (ПЗ) [26] були визначені як важливі чинники в патоґенезі ГП та його систем них ускладнень. Але попри проґрес у розумінні ран ніх подій за ГП потрібні дослідження для швидкого й точного проґнозування тяжкого перебігу хвороби, а також оптимального лікування.…”