Matrix Metalloproteinase-9 as a Marker for Acute Ischemic Stroke: A Systematic Review

Ramos-Fernández, María; Bellolio, M. Fernanda; Ganti, Latha

doi:10.1016/j.jstrokecerebrovasdis.2009.10.008

Cited by 185 publications

(168 citation statements)

References 24 publications

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“…As previously discussed, the consequence of an atherosclerotic plaque rupture is the thrombus-dependent impaired perfusion of heart and/or brain. The MMP-9 serum concentration is elevated in patients with acute ischemic events and this generally correlates with a poor prognosis, being strictly associated to edema formation (Ramos-Fernandez et al, 2011). In the acute event, microglia cells are stimulated by released pro-inflammatory factors to secrete large amounts of MMP-9, which the contributes to the blood-brain barrier (BBB) breakdown Copin et al, 2011;Del Zoppo et al, 2007).…”

Section: Angiogenesismentioning

confidence: 99%

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Sbardella

Fasciglione

Gioia

et al. 2012

Molecular Aspects of Medicine

209

212

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a b s t r a c tHuman matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site where a Zn 2+ atom, coordinated by three histidines, plays the catalytic role, assisted by a glutamic acid as a general base. Various MMPs display different domain composition, which is very important for macromolecular substrates recognition. Substrate specificity is very different among MMPs, being often associated to their cellular compartmentalization and/or cellular type where they are expressed. An extensive review of the different MMPs structural and functional features is integrated with their pathological role in several types of diseases, spanning from cancer to cardiovascular diseases and to neurodegeneration. It emerges a very complex and crucial role played by these enzymes in many physiological and pathological processes.

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Section: Angiogenesismentioning

confidence: 99%

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Sbardella

Fasciglione

Gioia

et al. 2012

Molecular Aspects of Medicine

209

212

View full text Add to dashboard Cite

show abstract

“…MMPs are involved in the development processes of experimental colitis (Esposito et al 2008b), endometriosis (Paul et al 2008), liver injury (Mishra et al 2011), traumatic experimental spinal cord injury (Esposito et al 2008a), acute ischemic stroke (Ramos-Fernandez et al 2010), and neurodegenerative diseases (Reyes et al 2009, Rosenberg 2009, Bauer et al 2010. Meanwhile, many studies also show that MMPs have contributed to tumor invasion, metastasis, and angiogenesis (Toth & Fridman 2001, Zhang et al 2003, Kessenbrock et al 2010, Pratheeshkumar & Kuttan 2011.…”

Section: Introductionmentioning

confidence: 99%

Melatonin inhibits IL1β-induced MMP9 expression and activity in human umbilical vein endothelial cells by suppressing NF-κB activation

Qin

Lu²,

Li³

et al. 2012

Journal of Endocrinology

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Matrix metalloproteinases (MMPs) have been involved in inflammatory and degradative processes in pathologic conditions. The purpose of this study was to investigate the protective effect of melatonin in human umbilical vein endothelial cell (HUVEC) monolayer permeability and the regulation of MMP9 induced by interleukin 1b (IL1b (IL1B)) in HUVECs. Protection studies were carried out with melatonin, a well-known antioxidant and antiinflammatory molecule. MMP9 expression was increased with IL1b induction in HUVECs. Melatonin showed a barrier-protective role by downregulation of MMP9 and upregulation of tissue inhibitor of metalloproteinase-1 expression in HUVECs. Meanwhile, melatonin also decreased sodium fluorescein permeability and counteracted the downregulation of vascular endothelial cadherin and occludin expression in HUVECs. During inflammatory stimulus, nuclear factor-kB (NF-kB) plays a significant role in regulating MMP genes expression, thus the function of NF-kB in HUVECs' barrier disruption was investigated. IL1b induced nuclear translocation of NF-kB in HUVECs and regulated MMP9 expression. However, NF-kB translocation into the nucleus was inhibited significantly by melatonin. Our results show that melatonin decreases the permeability of monolayer endothelial cell induced by IL1b. At the same time, melatonin decreased the expression and activity of MMP9 by a NF-kB-dependent pathway in HUVECs induced by IL1b.

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“…This is noteworthy since, under physiological conditions, sCD137 is generated by proteolytic cleavage from the cell surface of activated lymphocytes 38, 39. An upregulated specific MMP, i.e., gelatinase B and MMP‐9, which could cause the cleavage of CD137 from the cell surface during the acute stage of stroke,40, 41 may contribute to the increased release of sCD137. Our study demonstrated that plasma sCD137 levels tended to decrease following treatment, in parallel with the decreasing serum MMP‐9 levels after statin therapy 42, 43.…”

Section: Discussionmentioning

confidence: 99%

Increased Soluble CD137 Levels and CD4+ T‐Cell‐Associated Expression of CD137 in Acute Atherothrombotic Stroke

et al. 2018

Clinical Translational Sci

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As a proinflammatory cytokine, CD137 (4‐1BB, TNFRSF9) is present in membrane‐bound and soluble forms. Increased expression of CD137 was recently found in T cells in human atherosclerotic plaques. However, the exact role of CD137 in ischemic stroke is not clear. In this study we analyzed the protein levels of soluble CD137 (sCD137) and the expression of CD137 on CD4+ T cells in the peripheral blood of patients with acute atherothrombotic stroke by using the cytometry beads array (CBA) and flow cytometry. Within 24 hours of onset, the stroke patients showed elevated levels of sCD137 (2.7 pg/ml) and CD137 expression on CD4+ T cells (4.9 ± 3.2%) compared with normal controls (1.1 pg/ml, P < 0.01; 1.3 ± 1.0%, P < 0.01). Alterations in CD137 expression may enhance ischemia‐induced inflammatory responses via bidirectional signaling and, consequently, aggravate brain injury in early stages of this disorder.

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Matrix Metalloproteinase-9 as a Marker for Acute Ischemic Stroke: A Systematic Review

Cited by 185 publications

References 24 publications

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Melatonin inhibits IL1β-induced MMP9 expression and activity in human umbilical vein endothelial cells by suppressing NF-κB activation

Increased Soluble CD137 Levels and CD4+ T‐Cell‐Associated Expression of CD137 in Acute Atherothrombotic Stroke

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