Matrix metalloproteinase-9 in spontaneously hypertensive hyperlipidemic rats

Asano, Yasuhiko; Iwai, Shinichi; Okazaki, Masako; Kumai, Toshio; Munemasa, Yasunari; Oonuma, Shigeko; Tadokoro, Mamoru; Kobayashi, Shinichi; Oguchi, Katsuji

doi:10.1016/j.pathophys.2007.02.001

Cited by 13 publications

(11 citation statements)

References 38 publications

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“…MMPs are associated with cardiovascular disease and atherosclerosis ; in particular, MMP-2 and MMP-9 play important roles in the progression of atherosclerosis 11 , and MMP-9 activity is associated with oxidative stress in acute coronary syndrome 12 . Our previous studies showed that plasma MMP-9 activity is signi cantly higher and accompanied by aortic lipid deposition in SHHR compared to Sprague-Dawley SD control rats 5 . MMP-9 s role in the pathophysiology of atherosclerosis and plaque rupture 13 is tightly regulated by tissue inhibitors of metalloproteinases TIMPs 14 .…”

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confidence: 91%

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Visceral Fat Accumulation is Associated with Oxidative Stress and Increased Matrix Metalloproteinase-9 Expression in Atherogenic Factor-overlapped Model Rats

Tomita¹,

Iwai²,

Kumai

et al. 2010

Showa Univ J Med Sci

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confidence: 91%

“…SHHRs have persistently high levels of systolic blood pressure SBP above 150 mmHg and a plasma total cholesterol concentration above 150 mg / dL. In addition, vascular intimal lesions and lipid deposits were observed under endothelial cells in the aorta of SHHRs, but not spontaneously hyperlipidemic rats HLRs and controls 4,5 . Therefore,…”

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confidence: 92%

Visceral Fat Accumulation is Associated with Oxidative Stress and Increased Matrix Metalloproteinase-9 Expression in Atherogenic Factor-overlapped Model Rats

Tomita¹,

Iwai²,

Kumai

et al. 2010

Showa Univ J Med Sci

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“…In addition, vascular intimal lesions and lipid deposits have been observed under the endothelial cells in the aorta of SHHRs, but not in spontaneously hyperlipidemic rats or controls 8 . Moreover, invasive changes occur in the subendothelium of SHHR when nitric oxide production is inactivated, followed by a high fat diet and sucrose water treatment HFDS 9 , and a previous study found visceral fat accumulation and increased oxidative stress in SHHR-HFDS 10,11 .…”

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confidence: 85%

Increase in Matrix Metalloproteinase-2 and 9 in the Liver of Nonalcoholic Steatohepatitis (NASH) Model Rats

Tsuchiya

Iwai

Kumai

et al. 2011

Showa Univ J Med Sci

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“…There have been several studies exploring the relationship among MMPs, their inhibitors, and LV structure and function in patients with hypertension 13-18). MMPs are associated with cardiovascular disease and atherosclerosis; in particular, MMP-2 and MMP-9 play important roles in the progression of atherosclerosis 18).…”

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confidence: 99%

Metalloproteinase-3 Genotype as a Predictor of Cardiovascular Risk in Hypertensive Adolescents

2009

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Background and ObjectivesHypertension develops as a result of cardiac hypertrophy and fibrosis or as a result of exchange of the extracellular matrix. In particular, matrix metalloproteinase (MMP)-3 is a major enzyme involved in the reconstruction of the arterial intima through activation of other MMPs. We analyzed MMP-3 genotypes in hypertensive and normotensive adolescents and sought to determine if a particular genotype is a predictor of cardiovascular complications.Subjects and MethodsForty-four hypertensive adolescents and 59 healthy adolescents were included in this study. Serum aldosterone, renin, insulin, angiotensin converting enzyme (ACE), insulin, homocysteine, vitamin B12, folate, MMP-1, MMP-2, MMP-3, MMP-9, tissue inhibitors of matrix metalloproteinases (TIMP)-1, and TIMP-2 were measured. MMP-3 genotypes were analyzed using a polymerase chain reaction (PCR) primer. The carotid intima media thickness (IMT), diameter, and brachial ankle pulse wave velocity (baPWV) were evaluated using ultrasound.ResultsIn hypertensive adolescents, blood pressure, anthropometric data, carotid IMT, baPWV, serum pro-MMP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2 were no different between the 6A/6A group and the 5A/6A group. Serum MMP-9 was higher in the 5A/6A group than in the control group. Aldosterone, insulin, and homocysteine were higher in the 6A/6A group than in the control group, and vitamin B12 and folate were lower in the 6A/6A group than in the control group.ConclusionIn conclusion, serum MMP-3 levels were not significantly different in different MMP-3 genotypes in hypertensive adolescents. However, few patients were included in this study. Further investigation is necessary to clarify the relationship between MMP-3 genotype and cardiovascular risk.

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Matrix metalloproteinase-9 in spontaneously hypertensive hyperlipidemic rats

Cited by 13 publications

References 38 publications

Visceral Fat Accumulation is Associated with Oxidative Stress and Increased Matrix Metalloproteinase-9 Expression in Atherogenic Factor-overlapped Model Rats

Visceral Fat Accumulation is Associated with Oxidative Stress and Increased Matrix Metalloproteinase-9 Expression in Atherogenic Factor-overlapped Model Rats

Increase in Matrix Metalloproteinase-2 and 9 in the Liver of Nonalcoholic Steatohepatitis (NASH) Model Rats

Metalloproteinase-3 Genotype as a Predictor of Cardiovascular Risk in Hypertensive Adolescents

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