Matrix metalloproteinase enzymes and their naturally derived inhibitors: Novel targets in photocarcinoma therapy

Gupta, Anshita; Kaur, Chanchal Deep; Jangdey, Manmohan Singh; Saraf, Shailendra

doi:10.1016/j.arr.2013.12.001

Cited by 46 publications

(44 citation statements)

References 85 publications

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“…5,6) Inhibition of MMP-1 activation and expression has been shown to be important to alleviate UV-induced photo-damage to skin cells. 7,19,20) Compounds 4a-e showed significant protection of Cell viability is summarized from Fig. 2 for UVA and UVB irradiated HDF cells.…”

Section: )mentioning

confidence: 99%

“…7,20,21) To confirm the inhibition of compounds 4a-e on MMP-1 expression, the effect of these compounds on MMP-1 promoter activity was examined. The results shown in Fig.…”

Section: )mentioning

confidence: 99%

“…10) UVA is also known to significantly stimulate the expression and activation of MMPs. 7) In addition to the harmful effect of excess iron, catalytic zinc metal in the MMPs is essential for the degradation and remodeling of extracellular matrix proteins which may have profound effect on photoageing. Thus, development of metal chelating agents would be a promising approach in protection of skin cells against UVA-induced damages.…”

mentioning

confidence: 99%

“…[4][5][6] Therefore, inhibition of MMP production may prove effective for the treatment of photoaged skin. 7) Reactive oxygen species (ROS) is considered to be the main contributor to the deleterious effects of UVA-induced skin damage. UVA radiation of skin cells induces immediate release of iron from iron-binding proteins such as ferritin, which exacerbates the skin damaging effects.…”

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confidence: 99%

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Synthesis and Protective Effects of Bis{4-[N,N-di-(carboxymethyl)amino]phenoxy}alkane Derivatives on UVA-Induced Production of MMP-1 in Human Skin Fibroblasts

Hsu¹,

Chih-Ying

Huang

et al. 2014

CHEMICAL & PHARMACEUTICAL BULLETIN

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UV-induced matrix metalloproteinase (MMP) production is considered a cause of skin aging. In this study, a number of novel bis{4-[N,N-di-(carboxymethyl)amino]phenoxy}alkane derivatives were synthesized and evaluated as UVA-protective agents. These compounds significantly protected human dermal fibroblast (HDF) cells from UVA-induced cytotoxicity and inhibited MMP-1 activation and expression with potency comparable to desferoxamine (DFO). Promoter activity assay indicated that they inhibited MMP-1 expression at the transcriptional level. Further studies revealed that the mechanism of these compounds may include blockage of the UVA-induced activation of the p38/mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) pathways. Together, these results suggest that further development of these compounds may be of interest.

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Section: )mentioning

confidence: 99%

“…7,20,21) To confirm the inhibition of compounds 4a-e on MMP-1 expression, the effect of these compounds on MMP-1 promoter activity was examined. The results shown in Fig.…”

Section: )mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Synthesis and Protective Effects of Bis{4-[N,N-di-(carboxymethyl)amino]phenoxy}alkane Derivatives on UVA-Induced Production of MMP-1 in Human Skin Fibroblasts

Hsu¹,

Chih-Ying

Huang

et al. 2014

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…Photoaging represents another process in which the proteolytic activity of MMPs has a notorious and critical role; collagenases, in particular, are responsible for the decomposition of particular types of collagen and other proteins in the extracellular matrix of the dermis [7][8][9][10] . The breakdown of dermal collagen and elastin is purported to be one of the major contributing factors to loss of skin's firmness and elasticity.…”

Section: Introductionmentioning

confidence: 99%

Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity

Tauro

Laghezza

Loiodice

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

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New catechol-containing chemical entities have been investigated as matrix metalloproteinase inhibitors as well as antioxidant molecules. The combination of the two properties could represent a useful feature due to the potential application in all the pathological processes characterized by increased proteolytic activity and radical oxygen species (ROS) production, such as inflammation and photoaging. A series of catechol-based molecules were synthesized and tested for both proteolytic and oxidative inhibitory activity, and the detailed binding mode was assessed by crystal structure determination of the complex between a catechol derivative and the matrix metalloproteinase-8. Surprisingly, X-ray structure reveals that the catechol oxygens do not coordinates the zinc atom.

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Hydrogels loaded with MSC‐derived small extracellular vesicles: A novel cell‐free tissue engineering system for diabetic wound management

Zhong,

Meng,

et al. 2024

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With the aging and obesity era, the increasing incidence of diabetes and diabetic complications, especially the non‐healing wounds, imposes a serious economic burden on both patients and society. The complex microenvironments, including hyperglycemia, bacterial infection, ischemia, and nerve damage, lead to the prolonged inflammation and proliferation phase of diabetic wounds. Mesenchymal stem cell‐derived small extracellular vesicles (MSC‐sEVs), which contain a rich variety of therapeutic molecules, have been chased for decades because of their potential roles in cellular communication, tissue regeneration, and drug delivery. As powerful tools for the controlled‐sustained release of sEVs, biocompatible hydrogels have been applied in a wide range of biomedical applications. Herein, we first summarize the pathological features of diabetic wounds, such as angiopathy, neuropathy, and immune cell dysfunction. Then, we discuss the biological properties, therapeutic performance, and stability of pure MSC‐sEVs. After that, we discuss the components, application patterns, and responsiveness of hydrogels. Next, we discuss the loading avenues of MSC‐sEVs into hydrogel, the release behaviors of sEVs from hydrogels, and the influence of the crosslinking method on the hydrogel‐sEV composites. Finally, we provide an overview of the current applications of hydrogels loaded with MSC‐sEVs as a novel cell‐free tissue engineering system in managing diabetic wounds and propose the critical unsolved issues. This review is expected to provide meaningful guidance for developing a novel cell‐free tissue engineering system for diabetic wound management.

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Matrix metalloproteinase enzymes and their naturally derived inhibitors: Novel targets in photocarcinoma therapy

Cited by 46 publications

References 85 publications

Synthesis and Protective Effects of Bis{4-[<i>N</i>,<i>N</i>-di-(carboxymethyl)amino]phenoxy}alkane Derivatives on UVA-Induced Production of MMP-1 in Human Skin Fibroblasts

Synthesis and Protective Effects of Bis{4-[<i>N</i>,<i>N</i>-di-(carboxymethyl)amino]phenoxy}alkane Derivatives on UVA-Induced Production of MMP-1 in Human Skin Fibroblasts

Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity

Hydrogels loaded with MSC‐derived small extracellular vesicles: A novel cell‐free tissue engineering system for diabetic wound management

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