Matrix metalloproteinase7 -181A/G polymorphism is associated with increased cancer risk among high-quality studies: Evidence from a meta-analysis

Wu, Jing; Guan, Xuan; Li, Yating; Bai, Peng; Wu, Jin

doi:10.1016/j.clinbiochem.2013.07.015

Cited by 8 publications

(6 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another interesting subset of genes in our data are genes affecting cell adhesion and migration. The set of 28 shared and significant genes includes LAMC2 [ 33 , 34 ], MMP7 [ 44 ] and TNC [ 45 ]. We have previously described a large enrichment in somatic mutations in adhesion genes using the TCGA ovarian cancer data [ 46 ] while others have identified cell adhesion gene enrichment in a multidimensional study of ovarian cancer data [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Preferential Allele Expression Analysis Identifies Shared Germline and Somatic Driver Genes in Advanced Ovarian Cancer

et al. 2016

View full text Add to dashboard Cite

Identifying genes where a variant allele is preferentially expressed in tumors could lead to a better understanding of cancer biology and optimization of targeted therapy. However, tumor sample heterogeneity complicates standard approaches for detecting preferential allele expression. We therefore developed a novel approach combining genome and transcriptome sequencing data from the same sample that corrects for sample heterogeneity and identifies significant preferentially expressed alleles. We applied this analysis to epithelial ovarian cancer samples consisting of matched primary ovary and peritoneum and lymph node metastasis. We find that preferentially expressed variant alleles include germline and somatic variants, are shared at a relatively high frequency between patients, and are in gene networks known to be involved in cancer processes. Analysis at a patient level identifies patient-specific preferentially expressed alleles in genes that are targets for known drugs. Analysis at a site level identifies patterns of site specific preferential allele expression with similar pathways being impacted in the primary and metastasis sites. We conclude that genes with preferentially expressed variant alleles can act as cancer drivers and that targeting those genes could lead to new therapeutic strategies.

show abstract

Section: Discussionmentioning

confidence: 99%

Preferential Allele Expression Analysis Identifies Shared Germline and Somatic Driver Genes in Advanced Ovarian Cancer

et al. 2016

View full text Add to dashboard Cite

show abstract

“…There are differences in terms of allele distribution of MMP-7 or TIMP-2 polymorphisms between the Turkish population and other racial populations. However, MMP-7 A-181G and TIMP-2 G-418C allele distributions, in particular, are similar to the those in the Caucasian population [24,25]. Other polymorphisms have not been mostly investigated.…”

Section: Resultsmentioning

confidence: 90%

Analysis of MMP‐7 and TIMP‐2 gene polymorphisms in coronary artery disease and myocardial infarction: A Turkish case‐control study

Alp

Yılmaz

Tulmaç

et al. 2017

The Kaohsiung J of Med Scie

View full text Add to dashboard Cite

Matrix metalloproteinase (MMP) and tissue inhibitors of metalloproteinase (TIMP) have a significant role in tissue remodeling related to cardiac function. In earlier studies, MMP-7 A-181G (rs11568818), C-153T (rs11568819), C-115T (rs17886546), and TIMP-2 G-418C (rs8179090) polymorphisms have been studied in various diseases. However, association between coronary artery disease (CAD) and these polymorphisms has been poorly studied. The goal of this study is to investigate the association of CAD and myocardial infarction (MI) with MMP-7 or TIMP-2 polymorphisms. This study included 122 CAD patients and 132 control individuals. DNA was extracted from whole blood. Polymerase chain reaction-restriction fragment length polymorphism and automated direct sequencing method were used for genotyping of these polymorphisms. No significant differences were found between MMP-7 A-181G, C-115T, and TIMP-2 G-418C polymorphism and CAD or MI in a Turkish population. Despite the fact that the genotypes of MMP-7 C-153T polymorphism had no significant differences among MI and control groups, allele frequencies of C-153T polymorphism were significantly different between the two groups. Our study is the first report to clarify the appreciable relationship between MMP-7 C-153T polymorphism and MI development in CAD patients. However, these findings also need to be confirmed in other populations so we can improve our knowledge about the genetic factors affecting the development of CAD.

show abstract

“…Analyses of rs11568818 in MMP-7 performed in Chinese population suggested that rs11568818 may correlate with 2-fold increased risk of lung cancer (243 cases and 350 controls, OR = 2.0, 95% CI = 1.23-3.24 for AG and GG genotypes) [83], but not breast cancer (1079 cases and 082 controls) [55]. A meta-analysis of 24 studies encompassing 12 populations and including 10 different cancer sites revealed that MMP-7 SNP may be associated with the risk of various cancers, including gastric, colon, liver, bladder, cervix, ovary, breast, brain and lung, but only in Asian population (OR = 2.18, 95%CI 1.68-2.84) and not European (OR = 1.07, 95% CI 0.6-1.89) [79]. In our analysis the rs11568818 was not associated with the risk of breast and lung cancers.…”

Section: Discussionmentioning

confidence: 99%

“…Five SNPs, rs1799750 in MMP-1, rs243865 in MMP-2, rs11568818 in MMP-7, rs2252070 in MMP-13 and rs28366003 in MT2A has been studied in various cancers including breast [47][48][49][50][51][52][53][54][55][56][57], lung [47,[58][59][60][61][62][63][64] and colon cancer [44,47,[65][66][67][68][69][70][71][72][73][74][75], but results were ambiguous. The results of metaanalyses suggest that polymorphisms in MMP-1, MMP-2, and MMP-7 may be associated with cancer risk in Asian or Latin-American populations, but not in European or Caucasian populations [63,[76][77][78][79][80]. The MMPs and MTs are strongly associated with Zn homeostasis, so it is highly probable that the influence of SNPs in these genes on cancer risk may be dependent on Zn status.…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in MMP-1, MMP-2, MMP-7, MMP-13 and MT2A do not contribute to breast, lung and colon cancer risk in polish population

Białkowska

Marciniak

Muszyńska

et al. 2020

Hered Cancer Clin Pract

View full text Add to dashboard Cite

Background: Matrix metalloproteinases (MMPs) and metallothioneins (MTs) are Zinc-related proteins which are involved in processes crucial for carcinogenesis such as angiogenesis, proliferation and apoptosis. Several single nucleotide polymorphisms (SNPs) in MMPs and MTs that affect genes expression have been associated with cancer risk, including breast, lung and colon. Methods: The study group consisted of 648 unselected patients (299 with breast cancer, 199 with lung cancer, 150 with colon cancer) and 648 unaffected individuals. Five SNPs, rs1799750 in MMP-1, rs243865 in MMP-2, rs11568818 in MMP-7, rs2252070 in MMP-13 and rs28366003 in MT2A were genotyped and serum zinc (Zn) level was measured. The cancer risk was calculated using multivariable logistic regression with respect to Zn. Results: None of the 5 tested polymorphisms showed a correlation with cancer risk in studied groups, although for MMP-2, MMP-7 and MT2A non-significant differences in genotypes frequencies among cases and controls were observed. Conclusions: Analyses of polymorphisms, rs1799750 in MMP-1, rs243865 in MMP-2, rs11568818 in MMP-7, rs2252070 in MMP-13 and rs28366003 in MT2A in relation to serum Zn level did not show significant association with breast, lung and colon cancer risk among polish patients. Further studies are needed to verify this observation.

show abstract

Matrix metalloproteinase7 -181A/G polymorphism is associated with increased cancer risk among high-quality studies: Evidence from a meta-analysis

Cited by 8 publications

References 42 publications

Preferential Allele Expression Analysis Identifies Shared Germline and Somatic Driver Genes in Advanced Ovarian Cancer

Preferential Allele Expression Analysis Identifies Shared Germline and Somatic Driver Genes in Advanced Ovarian Cancer

Analysis of MMP‐7 and TIMP‐2 gene polymorphisms in coronary artery disease and myocardial infarction: A Turkish case‐control study

Polymorphisms in MMP-1, MMP-2, MMP-7, MMP-13 and MT2A do not contribute to breast, lung and colon cancer risk in polish population

Contact Info

Product

Resources

About