Matrix Proteases in Health and Disease

Ellis, Vincent

doi:10.1002/9783527649327

Cited by 5 publications

References 156 publications

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Self‐Assembled Nanomedicines for Anticancer and Antibacterial Applications

Zhou

Qiu

et al. 2018

Adv Healthcare Materials

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Self-assembly strategies have been widely applied in the nanomedicine field, which provide a convenient approach for building various structures for delivery carriers. When cooperating with biomolecules, self-assembly systems have significant influence on the cell activity and life process and could be used for regulating nanodrug activity. In this review, self-assembled nanomedicines are introduced, including materials, encapsulation, and releasing strategies, where self-assembly strategies are involved. Furthermore, as a promising and emerging area for nanomedicine, in situ self-assembly of anticancer drugs and supramolecular antibiotic switches is also discussed about how to regulate drug activity. Selective pericellular assembly can block mass transformation of cancer cells inducing cell apoptosis, and the intracellular assembly can either cause cell death or effectively avoid drug elimination from cytosol of cancer cells because of the assembly-induced retention (AIR) effect. Host-guest interactions of drug and competitive molecules offer reversible regulations of antibiotic activity, which can reduce drug-resistance and inhibit the generation of drug-resistant bacteria. Finally, the challenges and development trend in the field are discussed.

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Self‐Assembled Nanomedicines for Anticancer and Antibacterial Applications

Zhou

Qiu

et al. 2018

Adv Healthcare Materials

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Identification and function of proteolysis regulators in seminal fluid

LaFlamme

Wolfner

2012

Molecular Reproduction Devel

126

117

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Proteins in the seminal fluid of animals with internal fertilization effect numerous responses in mated females that impact both male and female fertility. Among these proteins is the highly represented class of proteolysis regulators (proteases and their inhibitors). Though proteolysis regulators have now been identified in the seminal fluid of all animals in which proteomic studies of the seminal fluid have been conducted (as well as several other species in which they have not), a unified understanding of the importance of proteolysis to male fertilization success and other reproductive processes has not yet been achieved. In this review, we provide an overview of the identification of proteolysis regulators in the seminal fluid of humans and Drosophila melanogaster, the two species with the most comprehensively known seminal fluid proteomes. We also highlight reports demonstrating the functional significance of specific proteolysis regulators in reproductive and post-mating processes. Finally, we make broad suggestions for the direction of future research into the roles of both active seminal fluid proteolysis regulators and their inactive homologs, another significant class of seminal fluid proteins. We hope that this review aids researchers in pursuing a coordinated study of the functional significance of proteolysis regulators in semen.

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u-Plasminogen Activator

Ellis

2013

Handbook of Proteolytic Enzymes

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Matrix Proteases in Health and Disease

Cited by 5 publications

References 156 publications

Self‐Assembled Nanomedicines for Anticancer and Antibacterial Applications

Self‐Assembled Nanomedicines for Anticancer and Antibacterial Applications

Identification and function of proteolysis regulators in seminal fluid

u-Plasminogen Activator

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