Matrix tablets based on carrageenans with dual controlled release of doxazosin mesylate

Pavli, Matej; Vrečer, Franc; Baumgartner, Stephan

doi:10.1016/j.ijpharm.2010.08.021

Cited by 36 publications

(18 citation statements)

References 37 publications

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“…The doxazosin ER dosage form is commercially available as a push-pull osmotic pump system in 4-and 8-mg tablets (28,29). Several strategies have been applied to develop modified release doxazosin formulations (e.g., using carrageenan matrices, pellets, and compression coated tablets) (30)(31)(32)3).…”

Section: Discussionmentioning

confidence: 99%

In Silico Simulation of Dissolution Profiles for Development of Extended-Release Doxazosin Tablets

Duque¹,

Issa²,

Silva³

et al. 2018

Dissolution Technol.

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Developing extended-release (ER) formulations with appropriate release characteristics can be challenging for formulation scientists. The aim of this study was to demonstrate the use of computer-simulated dissolution profiles associated with statistical experimental design in the development of doxazosin ER tablet formulations. Experimental doxazosin ER tablets were prepared and tested using USP Apparatus 2 with 900 mL of simulated gastric fluid without enzyme at 37 ± 0.5 °C and 75 rpm for 960 minutes. The results were used to optimize calibration constants for the ingredients in the simulation software, DDDPlus. Design Expert software was used to obtain different mixtures between lactose and HPMC K100M, creating seven formulations with dissolution profiles simulated in DDDPlus. After statistical analysis, an optimized doxazosin ER formulation was identified, manufactured, and tested for comparison with the predicted profile. A correlation coefficient of 0.99 was obtained for observed and predicted dissolution profiles of the optimized doxazosin ER formulation. The use of test simulations led to a 66.67% reduction in analyst working hours and 77.78% reduction in both equipment usage time and dissolution medium volume. Computer simulations associated with design of experiments can save time and reduce costs in the development of ER formulations.

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Section: Discussionmentioning

confidence: 99%

In Silico Simulation of Dissolution Profiles for Development of Extended-Release Doxazosin Tablets

Duque¹,

Issa²,

Silva³

et al. 2018

Dissolution Technol.

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show abstract

“…κ-karagenan hanya mempunyai satu gugus sulfat untuk setiap pengulangan unit disakarida sedangkan ι-karagenan mempunyai dua dan λ-karagenan mempunyai tiga gugus sulfat untuk setiap pengulangan unit disakarida. Hal ini mengakibatkan tiga varietas karagenan tersebut memiliki perbedaan densitas muatan yang linier (λ > ι > κ) 9 dan kelarutan (λ > ι > κ ) 6 . κ -karagenan hanya larut dalam air panas, sementara ιkaragenan dan λ-karagenan larut dalam air dingin dan panas 6,7 .…”

Section: Struktur Kimiaunclassified

Pengaturan Pelepasan Obat dari Tablet dengan Sistem Matriks Karagenan

Akbari

Chaerunisaa²,

Abdassah³

2020

Maj. Farmasetika

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Sistem matriks merupakan sistem pengaturan pelepasan obat dari tablet yang populer. Matriks tablet yang umum digunakan adalah golongan eter selulosa seperti hidroksi propil metil selulosa (HPMC), hidroksi propil selulosa (HPC) dan natrium karboksi metil selulosa (Na CMC). Golongan eter selulosa sintetik ini banyak digunakan karena memiliki sifat mengembang dan kompresibilitas yang baik. Polimer alam seperti karagenan telah banyak diteliti sebagai komponen penyusun matriks tablet untuk memperoleh pengaturan pelepasan obat dari matriks yang efektif. Karagenan dapat digunakan sebagai penyusun matriks mengingat polimer tersebut memiliki berat molekul yang besar dan mempunyai viskositas dan kemampuan membentuk gel yang tinggi. Dalam upaya pengembangan sistem matriks tablet dari bahan karagenan diperlukan pengetahuan yang baik mengenai karakteristik fisika kimia dari karagenan dan obat yang digunakan.Kata kunci : sistem matriks, karagenan, pembentukan gel.

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“…Particularly, CG based formulations are used for prolonged drug release, that is, for many hours or days [34, 35]. Some interesting features of CG like its adhesiveness and positive surface charge provide extra advantage in prolonging drug release in mucosal/epithelial tissues [36].…”

Section: Introductionmentioning

confidence: 99%

Carrageenan Based Bionanocomposites as Drug Delivery Tool with Special Emphasis on the Influence of Ferromagnetic Nanoparticles

Khan

Saba

Nawazish

et al. 2017

Oxidative Medicine and Cellular Longevity

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Over the past few years, considerable attention has been focused on carrageenan based bionanocomposites due to their multifaceted properties like biodegradability, biocompatibility, and nontoxicity. Moreover, these composites can be tailored according to the desired purpose by using different nanofillers. The role of ferromagnetic nanoparticles in drug delivery is also discussed here in detail. Moreover, this article also presents a short review of recent research on the different types of the carrageenan based bionanocomposites and applications.

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Matrix tablets based on carrageenans with dual controlled release of doxazosin mesylate

Cited by 36 publications

References 37 publications

In Silico Simulation of Dissolution Profiles for Development of Extended-Release Doxazosin Tablets

In Silico Simulation of Dissolution Profiles for Development of Extended-Release Doxazosin Tablets

Pengaturan Pelepasan Obat dari Tablet dengan Sistem Matriks Karagenan

Carrageenan Based Bionanocomposites as Drug Delivery Tool with Special Emphasis on the Influence of Ferromagnetic Nanoparticles

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