Matrix Therapy with RGTA OTR4120 Improves Healing Time and Quality in Hairless Rats with Deep Second-Degree Burns

Abstract

RGTA accelerated epidermal repair and protected the dermis from secondary effects of heat as quantified by zone-of-stasis size and extent of dermal remodeling.

RGTA® or ReGeneraTing Agents mimic heparan sulfate in regenerative medicine: from concept to curing patients

“…[19] Deep second degree burns-Accelerated epidermal repair.-Decreased zone of stasis and extent of dermal remodeling.Zakine et al . [27] Burn-related skin fibrosis-Normalization of collagen III/I levels.-Increased activity of MMP-2 and MMP-9.Garcia-Filipe [28]  Cornea  Corneal alkali burn-Enhanced re-epithelialization.-Reduction in ocular inflammation.-Histological changes (reduced edema, fibrosis, blood vessels, inflammatory cells).Brignole-Baudouin et al . [29] Corneal alkali burn-Decreased corneal inflammation.-Enhanced re-epithelialization.-Decreased neovascularization.-Healing of corneal ulcers following application 1 month post-injury.Cejkova et al .…”

Efectos de nuevos agentes regenerativos biomiméticos sobre la cicatrización corneal en un modelo experimental de úlceras posquirúrgicas

“…El RGTA-cacicol es un biopolímero diseñado imitando proteoglicanos de heparán sulfato y tiene características de acumulación y estabilización de los factores de crecimiento con capacidad de unión a heparina [25][26][27][28] . Es conocido por favorecer la cicatrización de heridas en distintas condiciones en diferentes sistemas in vivo [29][30][31][32] . Recientemente, Aifa et al (2012) describieron la reparación eficaz de úlceras crónicas en seres humanos usando gotas de RGTA.…”

Heparan Sulfate Proteoglycan Mimetics Promote Tissue Regeneration: An Overview

“…At day 1 and day 2, this number was 0; on and after day 60, this number was 6. (Zakine, Barbier et al 2011) …”

“…Dermal effects of RGTA OTR4120 administration are described in necrotic skin ulcers in mice (BarbierChassefiere, Garcia-Filipe et al 2009), incisional dermal wounds in rats (Barritault, GarciaFilipe et al 2010), second degree burns in rats (Garcia-Filipe, Barbier-Chassefiere et al 2007) (Zakine, Barbier et al 2011), a rat surgical excision model (Tong, Zbinden et al 2008;Tong, Tuk et al 2009;Tong, Tuk et al 2011) and in rat dermal ischemia ulcers (Tong, Tuk et al 2011). …”

“…A study by Zakine et al (2011), using this same model, revealed an increased reepithelialisation together with an increased number of keratinocyte layers and blood vessels in the RGTA OTR4120 administered group at the early stages of tissue regeneration that returned to control levels after 1 month post wounding ( Figure 6) (Zakine, Barbier et al 2011).…”