1984
DOI: 10.1016/0306-4522(84)90288-4
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Maturation of kainic acid seizure-brain damage syndrome in the rat. i. clinical, electrographic and metabolic observations

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Cited by 201 publications
(116 citation statements)
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“…The behavioral effects induced by systemic administration of KA varied with the postnatal age, as previously described (Ben-Ari et al, 1981;Tremblay et al, 1984). Thus, in P10 animals scratchinglike movements appeared after 20 -25 min of KA injection, rapidly followed by tonicoclonic seizures.…”
Section: Seizures In Developing and Adult Ratssupporting
confidence: 55%
See 1 more Smart Citation
“…The behavioral effects induced by systemic administration of KA varied with the postnatal age, as previously described (Ben-Ari et al, 1981;Tremblay et al, 1984). Thus, in P10 animals scratchinglike movements appeared after 20 -25 min of KA injection, rapidly followed by tonicoclonic seizures.…”
Section: Seizures In Developing and Adult Ratssupporting
confidence: 55%
“…Nonetheless, evidence that neuronal activity per se may not be sufficient to trigger TIMP-1 expression is provided by the absence of TIMP-1 induction in 10-d-old animals, despite intense seizure activity manifested by tonicoclonic seizures. Full limbic seizures and emerging signs of pathology in response to KA are not present in rats until the third postnatal week Tremblay et al, 1984), at which time TIMP-1 mRNA first was seen abundantly induced in the hippocampus and areas of projection. By 35 d postnatal, when both seizures and pathology are indistinguishable from those of adult rats, TIMP-1 expression extended to all limbic and limbic-related structures.…”
Section: Timp-1 Mrna Expression Is Upregulated Differentially In Adulmentioning
confidence: 98%
“…PTZ injections were stopped when animals reached stage 5 and, because of the rapid turnover of the drug, animals recovered normal behavior by 1 h after the last PTZ injection. The validity of relying on behavioral monitoring to assess seizure activity in the brain has been demonstrated previously by studies correlating electrophysiological measures with observed seizure behaviors (Tremblay et al, 1984).…”
Section: Evaluation Of Seizure Threshold By Multiple Pentylenetetrazomentioning
confidence: 90%
“…Fourteen of the 20 status epilepticus pups survived. Hallmarks of bilateral status epilepticus at this age are continuous hindlimb scratching, followed by swimming-like movements and prolonged tonic -clonic seizures (see Tremblay et al, 1984). The onset of tonic -clonic status epilepticus occurred within 30 min after kainic acid injection.…”
Section: Behavioral Manifestations Of Status Epilepticus Differ In P1mentioning
confidence: 93%