Maturation of Mismatch Negativity in Typically Developing Infants and Preschool Children

Abstract

The discriminative processes indexed by MMN in response to frequency changes areimmature in infants and preschool children. Although there is convincing evidence that the negativity elicited in Experiment 2 is an immature MMN, the possibility that it may be an "obligatory effect" indexing recovery from refractoriness cannot be ruled out at this time. The results from these experiments suggest that the MMN component haslimited use as a clinical tool at this time for infants and young children.

Enhancement of brain event-related potentials to speech sounds is associated with compensated reading skills in dyslexic children with familial risk for dyslexia

“…It has been shown to be relatively stable over the course of lifetime, being highly comparable with the adult response by early school-age ( eponien et al, 1998;Hämäläinen et al, 2011). However, in infancy its correspondence is sometimes called a mismatch response (MMR), because the polarity of the response can also be positive Dehaene-Lambertz, 2000;Morr, Shafer, Kreuzer, & Kurtzberg, 2002).…”

O Mismatch Negativity em pacientes com distúrbios do processamento auditivo (central)

“…12 It is the subtraction of auditory event-related potentials (AERP) obtained for a standard stimulus minus the AERP obtained for the deviant stimulus. 13 It is usually obtained using an oddball paradigm in which a repetitive standard stimulus is occasionally replaced by a deviant stimulus. 13 It may be elicited not only by pure tones and their elementary variants (frequency, duration, intensity, direction, etc.)…”

“…13 It is usually obtained using an oddball paradigm in which a repetitive standard stimulus is occasionally replaced by a deviant stimulus. 13 It may be elicited not only by pure tones and their elementary variants (frequency, duration, intensity, direction, etc.) but also by complex stimuli, including speech.…”

Auditory event-related potentials are related to cognition at preschool age after very preterm birth

“…The MMN, reflecting sound discrimination, is based on the automatic formation of neural memory traces for familiar auditory events and has been associated with preattentive cognitive processes in audition (9). While it is typically negative in adults, it may have a positive polarity in infants and young children (10). For salient sound changes, MMN is followed by the frontocentral P3a response, believed to represent an involuntary switch of attention (11).…”