Mature ovarian cystic teratoma with combined squamous cell carcinoma and malignant melanoma

Abstract

In a mature ovarian cystic teratoma (MOCT) in a 67-year-old woman we found associated invasive squamous cell carcinoma and nodular amelanotic malignant melanoma. The finding of foci of typical and atypical melanocytic proliferation at the junctional level of the dermal component together with the absence of other possible sources supports an ovarian origin of the melanoma. A comparative analysis of the reported MOCT-associated malignant melanomas emphasizes the singularity of our case in the amelanotic character of the melanoma, its lymphotropism and the coexistence of invasive squamous cell carcinoma.

Primary Malignant Melanoma Arising in an Ovarian Mature Cystic Teratoma - A Case Report and Literature Review -

“…In many studies, an increased serum LDH level is correlated with decreased survival in patients with advanced malignant melanoma. 7,14,20 Our patient also had a high serum LDH level (1,935 IU/L), and she survived only 5 months after operation.…”

“…As in previously reported cases, the patient was relatively old (71 years) and had general weakness, weight loss, and a palpable abdominal mass. 1,6,14,16,18 These findings all supported a diagnosis of primary ovarian malignant melanoma. To date, only 44 cases of primary malignant melanoma arising in a mature ovarian cystic teratoma have been reported.…”

“…Most of the reported ovarian malignant melanomas are metastatic, and only 44 cases are primary. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Teratoid elements must be identified in the ovary for the diagnosis of primary malignant melanoma because ovaries normally do not contain melaninproducing cells. 4 However, it is challenging to assess the primary site of ovarian malignant melanoma because it is almost always found in an advanced state, replacing entire ovarian structures, and this makes it difficult to determine whether the lesion is a primary ovarian melanoma.…”

Squamous Cell Carcinoma Arising in Mature Cystic Teratoma

“…The most common malignant change is squamous cell carcinoma (80%), with a few adenocarcinomas and malignant melanomas. 7,8,9 This case was complicated by squamous cell carcinoma. The tumor may extend beyond the ovary and even to distant sites.…”

Cistoadenocarcinoma mucinoso de baixo potencial de malignidade em coexistência com teratoma cístico maduro do ovário: relato de caso

“…A coexistência de dois tumores adjacentes, distintos histologicamente, em um mesmo órgão é denominada, por alguns autores, como tumores de colisão 1,2 . Uma série de relatos de casos rela-ciona a coexistência do teratoma maduro com outras neoplasias [1][2][3][4] , sendo que a presença de componente maligno pode ocorrer em cerca de 1-2% dos casos e, com maior freqüência, ocorre em mulheres menopausadas 5,6 . A neoplasia maligna que mais se associa ao teratoma maduro é o carcinoma epidermóide, que representa cerca de 80% dos casos.…”