Maxillary sinus lift response to platelet-rich plasma associated with autogenous bone, ceramic biphasic HA/β-TCP (70:30), or deproteinized bovine bone

Abstract

Background This study evaluated the long-term effects of platelet-rich plasma (PRP) on bone formation and regeneration when associated with autogenous bone graft (AB), porous biphasic calcium phosphate (pBCP), or deproteinized bovine bone (DBB) in maxillary sinus augmentation (MSA) of rabbit. Methods In 54 rabbits, bilateral MSA procedure was performed and randomly one sinus was filled with 200 mm3 material plus blood clot (AB/clot, DBB/clot, and pBCP/clot) and other with the same graft plus PRP (AB/PRP, DBB/PRP, and pBCP/PRP). After 30, 60, and 180 days, microtomographic were performed to analyze the three-dimensional MSA volume and histomorphometric analyses for the percentage of bone and soft tissues ingrowth. Data were compared by two-way ANOVA and the means were compared by the Tukey test, at p < 0.05. Results The percentage of pBCP and DBB were nearly unchanged throughout the whole period and bone formation occurred in the spaces between particles. The MSA volume filled with DBB and pBCP agglutinated with clot and PRP maintained constant during all experimental periods (147.2 mm3 and 154.9 mm3, respectively, p = 0.7377), and no significant changes in the new formatted bone and soft tissue were observed between treatments. In AB/clot and AB/PRP, the MSA volume was similar at 30 days (140.3 mm3 and 137.9 mm3, respectively), but a higher and gradual reduction was observed until 180 days. In the AB/PRP, this reduction was significantly higher (44.2%) than AB/clot (22.5%) (p = 0.01792). Histologically, the addition of PRP to AB accelerated the new bone formation/remodeling maintaining the percentage of new bone similar to AB/clot during all experimental volume (p = 0.6406), while the AB particles showed a higher resorption in AB/PRP than AB/clot until 60 days (mean of 7.8% and 15.1%, respectively, p = 0.0396). Conclusion The association of PRP with the autogenous graft accelerates the process of bone formation/remodeling in MSA, but not had influence on the pBCP and DBB groups.

Application Effect of External and Internal Elevation of Maxillary Sinus in Implant Restoration of Posterior Maxilla

“…This method can effectively improve the bone mass in the posterior maxillary area, reduce the occurrence of postoperative complications, and provide a guarantee for the corresponding function of dental implants. It has been widely used in clinical practice [ 5 , 6 ]. But at present, there is no unified conclusion about the choice of its surgical method.…”

Innovative Concepts and Recent Breakthrough for Engineered Graft and Constructs for Bone Regeneration: A Literature Systematic Review

“…This platelet concentrate releases growth factors and cytokines in a very short time and then reabsorbs in about 12–14 days. PRP has given the best results in combination with an autogenous graft compared to other materials used in bone regeneration [ 171 ]. However, the PRP gel in periodontology and dentoalveolar surgery has lost its use with the discovery of PRF, which has a lower cost and is easier to use [ 155 ].…”

Quantitative analysis of change in bone volume 5 years after sinus floor elevation using plate-shaped bone substitutes: a prospective observational study

“…Different types of artificial bone substitutes have been developed in the recent years, thereby increasing the frequency of bone grafts being performed without autogenous bone. Hydroxyapatite (HA), tricalcium phosphate (TCP) have been widely used as bone substitutes [ 8 – 11 ]. In general, HA has a very low resorption rate in the human body and can also slow new bone formation [ 12 ].…”