Maxillofacial Rhabdomyosarcoma in the Canine Maxillofacial Area

Nakaichi, Munekazu; Itamoto, Kazuhito; Hasegawa, Keiko; Morimoto, Masahiro; Hayashi, Toshiharu; Une, Satoshi; Taura, Yasuho; Tanaka, Katsuaki

doi:10.1292/jvms.69.65

Cited by 15 publications

(28 citation statements)

References 15 publications

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“…1,2,5,8 There are relatively few reports of this tumor in the veterinary literature. 1,[3][4][5][6][7][8][9]11,12,14 In humans, rhabdomyosarcoma is a common soft-tissue tumor in children. A predilection for the head and neck, genitourinary areas, retroperitoneum, and extremities is noted.…”

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confidence: 99%

Hematogenous metastasis of embryonal rhabdomyosarcoma originating from skeletal muscle in a young dog

et al. 2008

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Abstract. An 8-month-old, intact male Golden Retriever with a history of left forelimb lameness for 2 months was presented to the Veterinary Medical Teaching Hospital of Konkuk University (Seoul, Korea). Results of a physical examination revealed a mass in the left axillary region. A thoracic radiography showed an osteolytic lesion in the scapula and the presence of a soft tissue density from the thoracic wall to the scapula. A computerized tomography revealed a mass invading into the scapula, and small nodules in the lung that suggested metastasis. At necropsy, a pale-yellow, irregular, firm, 8 3 10 3 5 cm mass extended from axillary region and destroyed the scapular. In addition, small nodules were noted in the lung. On microscopic examination, the mass consisted of round-to-oval cells, with eccentrically located hyperchromatic nuclei and eosinophilic cytoplasm in fibromyxoid stroma. Tumor cells were observed in blood vessels in the primary mass. Tumor cells strongly expressed vimentin, desmin, and myoglobin. In phosphotungstic acid-hematoxylin staining, cross-striations were detected in rhabdomyoblasts. In periodic acid-Schiff reaction, only a few cells were detected. The diagnosis was primary rhabdomyosarcoma of the appendicular muscle of a young dog. The tumor presumably originated in the skeletal muscle of the limb, invaded into the adjacent scapular bone, and metastasized to the lung.

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Hematogenous metastasis of embryonal rhabdomyosarcoma originating from skeletal muscle in a young dog

et al. 2008

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“…It has been reported in various animals and also humans, being the most common sarcoma affecting children and young adults [10,12]. RMS defines a group of histological and genetically heterogeneous sarcomas and two major forms of the disease have been recognized: embryonal RMS (ERMS) and alveolar RMS (ARMS).…”

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“…According to the literature, the disease rarely affects domestic animals [8,17]. In dogs, the skeletal muscle of the tongue, larynx, myocardium and urinary bladder are the most common sites involved [2,10]. Even though two major forms are well recognized, the current classification of RMS distinguishes four variants based on the distinct histological appearances: embryonal, alveolar, botryoid and pleomorphic.…”

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Aggressive Spindle Cell Rhabdomyosarcoma in an 11-Month-Old Boxer Dog

Roza

Amorim

Carneiro

et al. 2010

The Journal of Veterinary Medical Science

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ABSTRACT. Rhabdomyosarcoma (RMS) is a malignant neoplasm derived from mesenchymal tissue with a tendency toward myogenic differentiation associated with the embryogenesis of skeletal muscle. According to the histological features, it can be classified in embryonal, botryoid, alveolar, and pleomorphic, which usually correspond to clinical behavior and prognosis. The spindle cell (SCRMS) variant is a rare subtype of the embryonal RMS and is considered to be less aggressive lesion. The aim of the present paper is to report an unusual case of SCRMS in an 11-month-old male boxer dog diagnosed as extensive SCRMS that affected the frontal region of the skull. Due to the aggressive nature of the lesion and poor clinical prognosis the dog's owners preferred euthanasia as a treatment. A full postmortem examination was carried out. Microscopically, the lesion was composed of a highly cellular proliferation of spindle cells arranged in long and intersecting fascicles. After performing the immunohistochemical studies (HHF-35, smooth muscle actin, desmin and MyoD1), the present case was diagnosed as SCRMS.

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“…However, there seems to be a trend of similarity with what has been reported in humans, regarding the fact that the majority of rMSs in dogs have occurred in tissues that normally do not contain striated-muscle cells, such as the pharynx, gingiva, urethra, trachea, larynx and the jawbone (Seibold, 1974;Sarnelli et al,1994;yanoff et al, 1996;Ginel et al, 2002;, Illanes, 2002;Kobayashi et al, 2004;Suzuki et al, 2006;Bae et al, 2007;Murakami et al, 2010). A few cases of canine rMSs have been reported to arise from striated muscles (Worley and Gorham, 1954;Gonin-Jmaa et al, 1996;Kim et al, 1996;Lascelles et al, 1998;Pérez et al, 1998;Cooper and Valentine, 2002;Machida et al, 2003;Brockus and Myers, 2004;Akkoc et al, 2006;Aupperle et al, 2007;Nakaichi et al, 2007;Chapman et al, 2008;yhee et al, 2008;yamate et al, 2011) and only some of them were further classified. Most of these rMSs were of the embryonal type.…”

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confidence: 99%

Rhabdomyosarcomas arising from striated muscles in elderly dogs: pathological features of 4 cases

Brellou

Psychas

Vlemmas

2017

J Hellenic Vet Med Soc

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Primary rhabdomyosarcomas are rare in dogs. Based on their classification, embryonal rhabdomyosarcoma is the most common, while alveolar and especially pleomorphic types occur less often. Four cases diagnosed as primary canine rhabdomyosarcomas of striated muscles were retrieved from our files. All the animals were cross-breeds, aged over 8 years. Two of them had died after developing disseminated intravascular coagulation and gastric ulcer, respectively, and two others were euthanized. Of those two, one had been admitted with neurological and cardiovascular symptoms and one with disseminated intravascular coagulation. Necropsy was performed and tissue samples were collected for histological and immunohistochemical examination. The first case was diagnosed as mixed rhabdomyosarcoma, pleomorphic type in the heart and the diaphragm and alveolar type in the lungs and the spleen. The three other cases were of alveolar type. One showed primary cardiac and oesophageal origin, with metastases in the skeletal muscles and non striated muscle tissues, one had primary cardiac, with mitral valve involvement, and skeletal muscle origin, with metastases in extra striated muscle tissues and one showed only skeletal muscle localization. Immunohistochemical examination revealed myoglobin and α-sarcomeric actin in tumour cells.

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Maxillofacial Rhabdomyosarcoma in the Canine Maxillofacial Area

Cited by 15 publications

References 15 publications

Hematogenous metastasis of embryonal rhabdomyosarcoma originating from skeletal muscle in a young dog

Hematogenous metastasis of embryonal rhabdomyosarcoma originating from skeletal muscle in a young dog

Aggressive Spindle Cell Rhabdomyosarcoma in an 11-Month-Old Boxer Dog

Rhabdomyosarcomas arising from striated muscles in elderly dogs: pathological features of 4 cases

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