Maximal Chemiluminescent Intensity in Response to Lipopolysaccharide Assessed by Endotoxin Activity Assay on Admission Day Predicts Mortality in Patients With Sepsis*

Abstract

Maximal chemiluminescent intensity level measured on admission day appears to have high predictive value for mortality in patients with sepsis.

Serum Total Cholinesterase Activity on Admission Is Associated with Disease Severity and Outcome in Patients with Traumatic Brain Injury

“…Sepsis was defined as a systemic response to an infection including the criteria for SIRS plus microbiological evidence of a focal infection and/or a positive blood culture. Septic shock was defined as sepsis-induced hypotension, persisting despite adequate fluid resuscitation, along with the presence of hypoperfusion abnormalities or organ dysfunction [ 35 ]. Patients were considered to suffer from SIRS if they met the criteria defined in the guidelines of the American College of Chest Physicians/Society of Critical Care Medicine [ 36 ].…”

The maximum chemiluminescence intensity predicts severe neutropenia in gemcitabine-treated patients with pancreatic or biliary tract cancer

“…Reduced oxidative activity may be associated with immune dysfunction and high mortality [ 25 , 26 ]. Kiguchi et al [ 18 ] reported that CI max before commencing treatment is indicative of the maximum neutrophil activity in whole blood and is highly predictive of mortality in patients with sepsis. CI max reflects neutrophil vitality or fatigue.…”

“…The resulting respiratory burst was detected by a chemiluminometer (Autolumat LB953; Berthold Technologies GmbH & Co. KG, Bad Wildbad, Germany) as light released from the lumiphore luminol. The maximum stimulated response (termed as CI max by Kiguchi et al [ 18 ]) was measured using lipopolysaccharide (4.6 ng/mL) as the stimulant.…”

“…Kiguchi et al [18] reported that the maximum chemiluminescence intensity (CI max ), as assessed by an in vitro reaction between peripheral neutrophils and endotoxin, is indicative of the maximum neutrophil activity in whole blood. A low CI max is also associated with the exhaustion of peripheral polymorphonuclear leukocytes.…”

“…Previous studies have demonstrated that risk factors for SN and febrile neutropenia include old age [ 10 , 11 ], female sex [ 12 ], a poor Eastern Cooperative Oncology Group performance status [ 13 ], a low body mass index [ 14 ], a small body surface area [ 15 ], a history of cardiovascular disease [ 10 ], diabetes mellitus [ 16 ], a poor nutritional status, inflammation [ 11 , 13 ], and a low baseline absolute neutrophil count (ANC) [ 17 ]. Kiguchi et al [ 18 ] reported that the maximum chemiluminescence intensity (CI max ), as assessed by an in vitro reaction between peripheral neutrophils and endotoxin, is indicative of the maximum neutrophil activity in whole blood. A low CI max is also associated with the exhaustion of peripheral polymorphonuclear leukocytes.…”