Maximum standardized uptake value of normal structures in the head and neck with bone SPECT/CT

Abstract

Introduction:The quantitative parameter was successfully derived from the quantitative bone SPECT/CT images. The aim of this study was to evaluate maximum standardized uptake value (SUV) of normal structures in the head and neck with bone SPECT/CT. Methods: Fifty-three patients with jaw lesions (11 chronic osteomyelitis, eight osteoradionecrosis and 34 medication-related osteonecrosis of the jaw) who had bone SPECT/CT were prospectively included. The maximum SUV of normal structures including vertebrae, sternal body, parietal bone and hyoid bone were analysed. Statistical analyses for the maximum SUV were performed by Pearson's rank correlation test. A P value lower than 0.05 was considered statistically significant. Results: The maximum SUVs of vertebrae, sternal body, parietal bone and hyoid bone of all patients were 8.10 AE 3.72, 5.16 AE 2.05, 3.67 AE 1.55 and 1.44 AE 0.56, respectively. Furthermore, the maximum SUV of vertebrae was significantly correlated with that of sternal body (Y = 0.527X + 5.388 (R 2 = 0.084, P = 0.035)). Conclusions: Maximum SUV with bone SPECT/CT should be useful for characterization of normal structures in the head and neck. Furthermore, the data reported herein can be used for reference in future studies and in clinical settings for head and neck lesions.

Comparison of maximum and mean standardized uptake values of jaw pathologies with bone SPECT/CT: an especial focus on medication-related osteonecrosis of the jaw

“…Regarding the maximum SUV using Q. Metrix and Xeleris workstation, we indicated the SUVs of jaw pathologies and the opposite side of the lesion as the control in Table 1. Tezuka et al [8] indicated that maximum SUVs were 8.10 ± 3.72 for vertebrae, 5.16 ± 2.05 for sternal body, 3.67 ± 1.55 for parietal bone and 1.44 ± 0.56 for hyoid bone. Furthermore, Zhang et al [25] explored the value of skeletal maximum SUV obtained by SPECT/CT in the differential diagnosis of bone metastases from benign lesions.…”

“…Tezuka et al . [8] indicated that maximum SUVs were 8.10 ± 3.72 for vertebrae, 5.16 ± 2.05 for sternal body, 3.67 ± 1.55 for parietal bone and 1.44 ± 0.56 for hyoid bone. Furthermore, Zhang et al .…”

“…The SPECT/CT data were obtained by using Q. Metrix and Xeleris workstation (GE Healthcare Japan, Tokyo, Japan), following our hospital’s protocol [8]. The maximum and mean SUVs of jaw pathologies were analyzed using CT, SPECT, SPECT/CT (transaxials, coronals and sagittals), and maximum intensity projection images were displayed on the workstation (Fig.…”

“…Bone SPECT/CT imaging was obtained by Optima NM/ CT 640 (GE Healthcare, Tokyo, Japan), following our hospital's protocol [8]. Patients were administered an intravenous injection of 740 MBq of Tc-99m hydroxymethylene diphosphonate before the acquisition.…”

“…Salivary gland SPECT/ CT provides quantitative imaging for the assessment of salivary dysfunction [3][4][5]. Furthermore, SUV using Q. Metrix and Xeleris workstation [6][7][8] and GI-BONE software [9][10][11][12][13] can be useful for the quantitative evaluation of jaw lesions with bone SPECT/CT. Therefore, SPECT/CT SUV is a promising technique for characterizing and differentiating lesions in the head and neck.…”