Mayaro Virus Infection: Clinical Features and Global Threat

Santos, Franciele Martins; Dias, Roberto Sousa; Fernandes, Luciana de Souza; Silva, Cynthia Cânedo da; Paula, Sérgio Oliveira de

doi:10.1007/s40506-020-00240-7

Cited by 5 publications

(5 citation statements)

References 70 publications

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“…Outside of these, wide ranging seroprevalence (21% to 72%) has been reported all across the region, and sporadic cases occur both within the region and abroad, in Europe and the USA through travelers 14,16 . Although primarily transmitted by Hemagogous mosquitoes, certain strains of MAYV have the ability to adapt to replicate in and be transmitted by different, more anthropophilic mosquito vectors 14,17,18 . This feature is a significant public health concern as it has enabled the broader dissemination of related viruses like CHIKV, suggesting a potential global spread of MAYV 14,17,18 .…”

Section: Introductionmentioning

confidence: 99%

“…Although primarily transmitted by Hemagogous mosquitoes, certain strains of MAYV have the ability to adapt to replicate in and be transmitted by different, more anthropophilic mosquito vectors 14,17,18 . This feature is a significant public health concern as it has enabled the broader dissemination of related viruses like CHIKV, suggesting a potential global spread of MAYV 14,17,18 .…”

Section: Introductionmentioning

confidence: 99%

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Development of RT-RPA-based point-of-care tests for epidemic arthritogenic alphaviruses

Sridhar,

Tonto,

Lumkong

et al. 2024

Preprint

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Chikungunya (CHIKV), onyong-nyong (ONNV), and Mayaro (MAYV) viruses are transmitted by mosquitoes and known to cause a debilitating arthritogenic syndrome. These alphaviruses have emerged and re-emerged, leading to outbreaks in tropical and subtropical regions of Asia, South America, and Africa. Despite their prevalence, there persists a critical gap in the availability of sensitive and virus-specific point-of-care (POC) diagnostics. Traditional immunoglobulin-based tests such as enzyme-linked immunosorbent assay (ELISAs) often yield cross-reactive results due to the close genetic relationship between these viruses. Molecular diagnostics such as quantitative polymerase chain reaction (qPCR) offer high sensitivity but are limited by the need for specialized laboratory equipment. Recombinase polymerase amplification (RPA), an isothermal amplification method, presents a promising alternative to qPCR, providing rapid results with minimal equipment requirements. Here, we report the development and validation of three virus-specific RPA-based rapid tests for CHIKV, ONNV, and MAYV. These tests demonstrated both speed and sensitivity, capable of detecting 10 viral copies within 20 minutes of amplification, without exhibiting cross-reactivity to related alphaviruses and other arboviruses. Furthermore, we evaluated the clinical potential of these tests using serum and tissue samples from CHIKV, ONNV, and MAYV-infected mice. Ultimately, findings highlight the significance of these rapid and specific POC diagnostics in improving the early detection and management of these arboviral infections.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of RT-RPA-based point-of-care tests for epidemic arthritogenic alphaviruses

Sridhar,

Tonto,

Lumkong

et al. 2024

Preprint

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show abstract

“…Mayaro virus (MAYV) is a positive-sense single-stranded RNA virus in the Alphavirus genus that spreads among humans by the bite of infected mosquitoes. In most cases, human infection causes influenza-like illness (3–5-day duration) or may lead to severe debilitating arthralgia that persists for months [ 1 , 2 , 3 ]. MAYV has been detected through virus isolation or antibodies in several countries, such as Brazil, Venezuela, Ecuador, Peru, Panama, Mexico, French Guiana, and Colombia [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Temperature-Mediated Effects on Mayaro Virus Vector Competency of Florida Aedes aegypti Mosquito Vectors

Alomar

Alto

2022

Viruses

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Mayaro virus (MAYV) is an emerging mosquito-borne arbovirus and public health concern. We evaluated the influence of temperature on Aedes aegypti responses to MAYV oral infection and transmission at two constant temperatures (20 °C and 30 °C). Infection of mosquito tissues (bodies and legs) and salivary secretions with MAYV was determined at 3, 9, 15, 21, and 27 days post ingestion. At both temperatures, we observed a trend of increase in progression of MAYV infection and replication kinetics over time, followed by a decline during later periods. Peaks of MAYV infection, titer, and dissemination from the midgut were detected at 15 and 21 days post ingestion at 30 °C and 20 °C, respectively. Mosquitoes were able to transmit MAYV as early as day 3 at 30 °C, but MAYV was not detectable in salivary secretions until day 15 at 20 °C. Low rates of MAYV in salivary secretions collected from infected mosquitoes provided evidence supporting the notion that a substantial salivary gland barrier(s) in Florida Ae. aegypti can limit the risk of MAYV transmission. Our results provide insights into the effects of temperature and time on the progression of infection and replication of MAYV in Ae. aegypti vectors.

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“…MAYV is maintained in a sylvatic cycle using Haemagogus janthinomys mosquitoes as primary vectors and a variety of mammalian species as reservoirs such as rodents, birds, and non-human primates [6]. Although considered endemic to rural areas, MAYV has been detected in urban areas in Brazil (frequently in the Mato Grosso State, central region), potentially being transmitted by urbanized vectors such as Aedes spp and Culex spp [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…Although non-lethal, Mayaro fever can severely impact an individual's life quality. Thus, the similarity of symptoms to other arboviral diseases, such as chikungunya and dengue fever, often impairs correct diagnosis [6,16,17].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antiviral Activity of Cyclic Ketones against Mayaro Virus

Fernandes

Silva

Dias

et al. 2021

Viruses

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Mayaro virus (MAYV) is a neglected arthropod-borne virus found in the Americas. MAYV infection results in Mayaro fever, a non-lethal debilitating disease characterized by a strong inflammatory response affecting the joints and muscles. MAYV was once considered endemic to forested areas in Brazil but has managed to adapt and spread to urban regions using new vectors, such as Aedes aegypti, and has the potential to cause serious epidemics in the future. Currently, there are no vaccines or specific treatments against MAYV. In this study, the antiviral activity of a series of synthetic cyclic ketones were evaluated for the first time against MAYV. Twenty-four compounds were screened in a cell viability assay, and eight were selected for further evaluation. Effective concentration (EC50) and selectivity index (SI) were calculated and compound 9-(5-(4-chlorophenyl]furan-2-yl)-3,6-dimethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2))-dione (9) (EC50 = 21.5 µmol·L–1, SI = 15.8) was selected for mechanism of action assays. The substance was able to reduce viral activity by approximately 70% in both pre-treatment and post-treatment assays.

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Mayaro Virus Infection: Clinical Features and Global Threat

Cited by 5 publications

References 70 publications

Development of RT-RPA-based point-of-care tests for epidemic arthritogenic alphaviruses

Development of RT-RPA-based point-of-care tests for epidemic arthritogenic alphaviruses

Temperature-Mediated Effects on Mayaro Virus Vector Competency of Florida Aedes aegypti Mosquito Vectors

Evaluation of Antiviral Activity of Cyclic Ketones against Mayaro Virus

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