Maytenus robusta Reissek, a medicinal plant popularly used to treat digestive diseases, promotes ameliorative effects in colon and liver of mice exposed to dextran sulfate sodium

Mees, Mariéli; Meurer, Marianne Caroline; Mariano, Luísa Nathália Bolda; Boeing, Thaise; Somensi, Líncon Bordignon; Mariott, Marihá; Niero, Rivaldo; Cechinel‐Filho, Valdir; Andrade, Sérgio Faloni de; Duarte, Lucienir Pains; Sousa, Grasiely Faria de; Souza, Priscila de; Silva, Luísa Mota da

doi:10.1016/j.jep.2020.113180

Cited by 5 publications

(1 citation statement)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nonetheless, MTX treatment causes intestinal inflammation in mice and increases apoptosis by elevating Bax and caspase-9 expression levels, while inhibiting Bcl-2 expression levels through OS ( Aldhahrani, 2021 ). Similarly, ROS can be produced due to goblet cell depletion in the colon tissues of the dextran sulfate sodium (DSS)-induced UC mice model ( Mees et al, 2020 ). Recent studies showed that the OS damage to rat intestinal Paneth cells due to aluminum and ionizing radiation alters the abnormal cell morphology, such as the expansion of crypt cavity and the erosion of villus, induces apoptosis of crypt cells, and causes bacterial invasion in Paneth cells ( Eltahawy et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress in Wernicke’s encephalopathy

Wei

2023

Front. Aging Neurosci.

View full text Add to dashboard Cite

Wernicke’s encephalopathy (WE) is a severe life-threatening disease that occurs due to vitamin B1 (thiamine) deficiency (TD). It is characterized by acute mental disorder, ataxia, and ophthalmoplegia. TD occurs because of the following reasons: insufficient intake, increased demand, and long-term drinking due to corresponding organ damage or failure. Recent studies showed that oxidative stress (OS) can damage organs and cause TD in the brain, which further leads to neurodegenerative diseases, such as WE. In this review, we discuss the effects of TD caused by OS on multiple organ systems, including the liver, intestines, and brain in WE. We believe that strengthening the human antioxidant system and reducing TD can effectively treat WE.

show abstract

Section: Introductionmentioning

confidence: 99%