New insights in intestinal oxidative stress damage and the health intervention effects of nutrients: A review

Wang, Yajie; Chen, Yue; Zhang, Xiaoyu; Lu, Yangpeng; Chen, Hạixia

doi:10.1016/j.jff.2020.104248

Cited by 143 publications

(103 citation statements)

References 137 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our study, urinary sphingolipid levels increased with soft stools, suggesting that the urinary condition tended to be oxidized in soft stools. Many studies have reported that oxidative stress is involved in in ammation and affects gut health, and the results of this study con rm previous data 51,52 .…”

Section: Discussionsupporting

confidence: 92%

Multi-omics Analysis of Redox Imbalance-Related Mild Health Problems in Monkeys

Hamano

Tokuoka

Ishibashi

et al. 2021

Preprint

View full text Add to dashboard Cite

Certain symptoms associated with mild sickness and lethargy have not been categorized as definitive diseases. Confirming such symptoms in captive monkeys (Macaca fascicularis) can be difficult; however, it is possible to observe and analyze their feces. Even among monkeys that are housed under carefully monitored conditions, some monkeys occasionally have poor stool conditions. In this study, we investigated the relationship between stool state and various omics data by considering objective and quantitative values of stool water content as a phenotype for analysis. By examining the food intake of the monkeys, the stool and urine they expel, and the plasma circulating in their bodies, we attempted to obtain a comprehensive understanding of the health status of a single individual and understand its relationship with stool condition. Our metabolomics data strongly suggested an association between lipids and stool water content. Lipidomic analysis revealed the involvement of saturated and oxidized fatty acids, metallomics revealed the contribution of selenium (a bio-essential trace element), and intestinal microbiota analysis revealed the association of several bacterial species with the stool water content. Taken together, these results suggest that selenium-induced disturbance in redox balance may cause minor health problems.

show abstract

Section: Discussionsupporting

confidence: 92%

Multi-omics Analysis of Redox Imbalance-Related Mild Health Problems in Monkeys

Hamano

Tokuoka

Ishibashi

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Reactive oxygen species (ROS) are generated along with the process of cell respiration and normal metabolism continuously, and mitochondrion is the primary source of the majority of ROS in organisms ( Wang Y. et al, 2020 ; Yan Z. et al, 2020 ). ROS includes free radical ROS and non-radical ROS.…”

Section: Lonicera Japonica (Extracts) and Intestinal Antioxidantmentioning

confidence: 99%

Potential Application of Lonicera japonica Extracts in Animal Production: From the Perspective of Intestinal Health

et al. 2021

View full text Add to dashboard Cite

Lonicera japonica (L. japonica) extract is rich in active substances, such as phenolic acids, essential oils, flavones, saponins, and iridoids, which have a broad spectrum of antioxidant, anti-inflammatory, and anti-microbial effect. Previous studies have demonstrated that L. japonica has a good regulatory effect on animal intestinal health, which can be used as a potential antibiotic substitute product. However, previous studies about intestinal health regulation mainly focus on experimental animals or cells, like mice, rats, HMC-1 Cells, and RAW 264.7 cells. In this review, the intestinal health benefits including antioxidant, anti-inflammatory, and antimicrobial activity, and its potential application in animal production were summarized. Through this review, we can see that the effects and mechanism of L. japonica extract on intestinal health regulation of farm and aquatic animals are still rare and unclear. Further studies could focus on the regulatory mechanism of L. japonica extract on intestinal health especially the protective effects of L. japonica extract on oxidative injury, inflammation, and regulation of intestinal flora in farm animals and aquatic animals, thereby providing references for the rational utilization and application of L. japonica and its extracts in animal production.

show abstract

“…ROS are unstable and oxygen-centered molecules containing unpaired-valence electrons which are highly reactive with proteins, lipids, carbohydrates and nucleic acids in the cell. It includes radical compounds (superoxide (O 2 − ), hydroxyl radicals (HO), lipid hydroperoxides) and reactive non-radical compounds or oxidants (oxygen ( 1 O 2 ), ozone (O 3 ), hydrogen peroxide (H 2 O 2 ), hypochlorous acid (HOCl), hypobromous acid (HOBr), chloramines (RNHCl) and organic hydroperoxides (ROOH)), which can impair intestinal cells, leading to OS [ 53 , 54 , 55 ]. The animal body is equipped with antioxidant defense system which is responsible against the deleterious effect of ROS.…”

Section: Heat Stress and Its Induced Stressorsmentioning

confidence: 99%

“…Other antioxidant enzymes also have a significant role; GPx is responsible for the conversion of GSH into glutathione disulfide (GSSG), which reduces H 2 O 2 to H 2 O and lipid hydroperoxides to stable alcohols. Conversely, GR can reduce GSSG to GSH which maintains the balance of cell differentiation, growth and apoptosis [ 53 , 57 , 58 ]. Non-enzymatic antioxidants such as GSH, Trx and Mel interrupt free radical chain reaction.…”

Section: Heat Stress and Its Induced Stressorsmentioning

confidence: 99%

“…Trx serves as donors of electron to peroxidase to efficiently scavenge ROS, while Mel can efficiently protect the mitochondria from oxidative damage through its direct free radical scavenging capability; whilst other antioxidants can be converted into free radicals, the said conversion does not apply to Mel as its oxidative role involves donation of two electrons. These mechanisms can then result in reduced lipid peroxidation, DNA damage, protein activation and restoration of intestinal injury induced by OS [ 53 , 55 , 59 ]. Antioxidant to pro-oxidant balance in the intestine is an essential determinant of human [ 60 ] and pig gut health [ 61 ].…”

Section: Heat Stress and Its Induced Stressorsmentioning

confidence: 99%

See 1 more Smart Citation

Adverse Effects of Heat Stress on the Intestinal Integrity and Function of Pigs and the Mitigation Capacity of Dietary Antioxidants: A Review

Ortega

Szabó

2021

Animals

View full text Add to dashboard Cite

Heat stress (HS) significantly affects the performance of pigs by its induced stressors such as inflammation, hypoxia and oxidative stress (OS), which mightily strain the intestinal integrity and function of pigs. As heat stress progresses, several mechanisms in the intestinal epithelium involved in the absorption of nutrients and its protective functions are altered. Changes in these mechanisms are mainly driven by cellular oxidative stress, which promotes disruption of intestinal homeostasis, leading to intestinal permeability, emphasizing intestinal histology and morphology with little possibility of recovering even after exposure to HS. Identification and understanding of these altered mechanisms are crucial for providing appropriate intervention strategies. Therefore, it is this papers’ objective to review the important components for intestinal integrity that are negatively affected by HS and its induced stressors. With due consideration to the amelioration of such effects through nutritional intervention, this work will also look into the capability of dietary antioxidants in mitigating such adverse effects and maintaining the intestine’s integrity and function upon the pigs’ exposure to high environmental temperature.

show abstract

New insights in intestinal oxidative stress damage and the health intervention effects of nutrients: A review

Cited by 143 publications

References 137 publications

Multi-omics Analysis of Redox Imbalance-Related Mild Health Problems in Monkeys

Multi-omics Analysis of Redox Imbalance-Related Mild Health Problems in Monkeys

Potential Application of Lonicera japonica Extracts in Animal Production: From the Perspective of Intestinal Health

Adverse Effects of Heat Stress on the Intestinal Integrity and Function of Pigs and the Mitigation Capacity of Dietary Antioxidants: A Review

Contact Info

Product

Resources

About