MbIDGF, a novel member of the imaginal disc growth factor family in Mamestra brassicae, stimulates cell proliferation in two lepidopteran cell lines without insulin

Silkworm egg proteins at the germ-band formation stage and a functional analysis of BmEP80 protein

“…A B. mori imaginal disk growth factor (BmIDGF) was found in this analysis. The function of its homolog in Mamestra brassicae, MbIDGF, has been extensively studied by Zhang et al (2006a). These studies revealed that MbIDGF stimulated the growth of lepidopteran cells in a dose-dependent manner through a new mechanism dissociated from the insulin pathway in moths.…”

Autophagy and its physiological relevance in arthropods: Current knowledge and perspectives

“…Proteomic analysis of the medium conditioned by oligomycin A-treated cells indicates a dramatic reduction in the secretion of an Imaginal Disk Growth Factor (IDGF)-like protein. 150 IDGF family members are proteins that play a fundamental role in promoting the growth and survival of Mamestra brassicae fat body cells and hemocytes, 152 of larval hemocytes of the flesh fly Sarcophaga peregrina, 153 and of imaginal disk cells in D. melanogaster. 154 In the larvae of the silkworm B. mori, the synthesis of IDGF is modulated on the basis of food availability.…”

Growth and mitogenic effects of arylphorin in vivo and in vitro

“…Aqueous extracts of fat body have also been shown to support the growth and development of imaginal wing discs of several lepidopteran species (Benson et al, 1974;Smagghe et al, 2001) (Zhang et al, 2006). Another distinct factor, of neural origin, bombyxin (4,5005,000 Da), is an insulin-like peptide that functions as a growth factor for wing imaginal discs in the buckeye butterfly, Precis coenia (Nijhout and Grunert, 2002) and for mixed and stem cell primary/secondary cultures of midgut cells derived from M. brassicae and the tobacco budworm H. virescens (Goto et al, 2005).…”