MBL serum concentration in women with HPV presenting CIN III lesions

Ramos, Guilherme Piovezani; Nisihara, Renato; Maestri, Carlos Afonso; Bicalho, Maria Gabriela Parenti; Carvalho, Newton Sérgio de; Reason, Iara de Messias

doi:10.1016/j.humimm.2012.09.008

Cited by 2 publications

(3 citation statements)

References 12 publications

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“…The current data showed no statistically significant difference between median MBL serum levels of women presenting with CIN-III cervical lesions compared to healthy controls, as previously reported on MBL serum concentrations in HPV-infected women [17].…”

Section: Discussionsupporting

confidence: 82%

“…Ramos et al [17] have previously reported on MBL concentrations in women presenting with HPV-associated cervical lesions, but there was no statistically significant difference between the median serum MBL levels in HPV-infected women presenting with CIN-III lesions and healthy controls. There are still no reports on MBL concentrations in women presenting with CIN-I and II or invasive cervical cancer.…”

Section: Introductionmentioning

confidence: 84%

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Mannose-Binding Lectin Does Not Act as a Biomarker for the Progression of Preinvasive Lesions of Invasive Cervical Cancer

Maestri¹,

Nisihara²,

Ramos³

et al. 2017

Med Princ Pract

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Objective: To evaluate serum concentrations of mannose-binding lectin (MBL) in women presenting with different human papillomavirus (HPV)-associated cervical lesions. Subjects and Methods: A total of 364 women, who underwent screening for cervical cancer or treatment at the Erasto Gaertner Cancer Hospital (HEG), Curitiba, Brazil, were enrolled in the study. Based on the latest cervical colposcopy-guided biopsy results, the women were divided into 4 groups: cervical intraepithelial neoplasia CIN-I (n = 54), CIN-II (n = 72), CIN-III (n = 145), and invasive cancer (n = 93). A time-resolved immunofluorometric assay was used to measure the MBL concentrations in serum. The statistical analysis was done using GraphPad Prism 6.0. Comparisons were performed by Kruskal-Wallis and Mann-Whitney tests and analyzed by χ² test; continuous variables are presented as medians and categorical variables as frequencies. Results: The median MBL concentrations in decreasing order were as follows: invasive cancer: 1,452 ng/mL, CIN-I: 1,324 ng/mL, CIN-II: 1,104 ng/mL, and CIN-III 1,098 ng/mL. However, no statistical significance was found among the 4 groups with HPV-associated lesions (p = 0.11). Equally, the MBL levels did not show a significant association between the age of the patients and the severity of the cervical lesions (p = 0.68). No statistical significance was found in the median values of MBL or in the status of MBL deficient (<100 ng/mL) and high producers (>1,000 ng/mL) among the women in each group (p = 0.77). Conclusion: In this study, there was no statistically significant difference in MBL serum levels among the groups with CIN. Hence MBL serum concentration appeared not to have influenced the progression of HPV-related preinvasive cervical lesions into invasive cancer.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 84%

Mannose-Binding Lectin Does Not Act as a Biomarker for the Progression of Preinvasive Lesions of Invasive Cervical Cancer

Maestri¹,

Nisihara²,

Ramos³

et al. 2017

Med Princ Pract

Self Cite

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“…Nevertheless, MBL2 genetic variants were associated previously with susceptibility to HPV infection in Brazilian [Guimaraes et al, ], Taiwan [Tsai et al, ] and Italian subjects [Segat et al, ] but not in a southern Brazilian [Ramos et al, ] and in a center‐southern Italian populations [Parrella et al, ]. HPV is a non‐enveloped virus, and actually it is not known if MBL could interact directly with the virus; nevertheless MBL can bind to IgA and then activate the lectin pathway of complement system [Roos et al, ], and some works observed an association between low IgA levels and increased susceptibility towards HPV infection [Bierl et al, ; Nguyen et al, ; Gonçalves et al, ].…”

Section: Discussionmentioning

confidence: 99%

MBL2polymorphisms in women with atypical squamous cells of undetermined significance

et al. 2015

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Infection with high risk Human papillomavirus (HPV) is the main known cause of cervical cancer. HPV induces different grades of lesions: among them, Atypical squamous cells of undetermined significance are abnormal lesions that could evolve in pre-cancer lesions or spontaneously regress. The mannose binding lectin (MBL) is an innate immunity serum protein also found in cervico-vaginal mucosa, whose expression is known to be affected by polymorphisms in exon 1 and promoter of the MBL2 gene. In the present study the possible association between MBL2 functional polymorphisms and susceptibility to develop atypical squamous cells of undetermined significance was investigated in a group of women from North-East of Italy, stratified for HPV infection status. The MBL2 D and O alleles and the deficient producer combined genotypes, responsible for low MBL production, were more represented among atypical squamous cells of undetermined significance positive women than healthy controls and the results were confirmed when only HPV negative samples were considered. These results suggest a possible involvement of MBL2 functional polymorphisms in atypical squamous cells of undetermined significance susceptibility.

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MBL serum concentration in women with HPV presenting CIN III lesions

Cited by 2 publications

References 12 publications

Mannose-Binding Lectin Does Not Act as a Biomarker for the Progression of Preinvasive Lesions of Invasive Cervical Cancer

Mannose-Binding Lectin Does Not Act as a Biomarker for the Progression of Preinvasive Lesions of Invasive Cervical Cancer

MBL2polymorphisms in women with atypical squamous cells of undetermined significance

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