The use of design thinking, lean startup, and high‐technology marketing in systems engineering is presented as a case study. All were used and evaluated for their potential to improve systems engineering processes and design, address the challenges of culture change, increase the adoption rate of new technology, and engage with potential users and sponsors more effectively. Multiple examples of training and use on a Model‐Based Systems Engineering (MBSE) initiative at a large government agency showcase how these approaches were tailored and used successfully for significant benefits such as enhanced collaboration and better problem definition and design solutions. Challenges remain for use by quiet thinkers and with virtual teams. These new ways of thinking are well aligned with creating and using new technologies and are suitable for situations involving innovation, uncertainty, and change within organizations. This case study intends to familiarize systems engineers with the application of these human‐centered approaches, to interest systems engineers in incorporating these approaches into their work processes, and to inspire the systems engineering research community to investigate further.