McCune-Albright syndrome associated with a functioning pituitary chromophobe adenoma

Gigantism Associated with McCune-Albright's Syndrome

“…The case reported by Scurry, Bicknell and Fajans (1964) was considered to have pituitary tumor by polytomography of the sella, the case of Lightner, Robert and Frasier (1975), Lightner, Penny and Frasier (1976) was found to have eosinophilic pituitary adenoma, and the case of Joishy and Morrow (1976) was due to chromophobe adenoma. The most recently reported case by Lipson and Hsu (1981) was found to have a pituitary and suprasellar mass and was effectively treated by 5000 rads of external radiotherapy to the sella and suprasellar regions.…”

“…17 (1985) H. Nakagawa, A. Nagasaka, T. Sugiura, K. Nakagawa, Y. Yabe, N. Nihei et al crine adenomatosis. This syndrome is rarely accompanied by gigantism or acromegaly (Scurry, Bicknell and Fajans 1964;Lightner, Robert andFrasier 1975;Scully and McNeely 1975;Joishy and Morrow 1976;Carr,Mathie, Manners and Colman 1979;Lipson and Hsu 1981 ;Higashihara, Takano, Murase, Murakami, Sasaki, Ishibashi, Yamaji, Osawa and Kosaka 1982).…”

“…Sexual precocity is the most common endocrine dysfunction in McCune-Albright's syndrome, which consists of the triad of fibrous dysplasia of bone, endocrine dysfunctions and cutaneous pigmentation, and is more common in girls than in boys (Lipson and Hsu 1981). This syndrome is rarely accompanied by gigantism (Lightner, Robert and Frasier 1975;Joishy and Morrow 1976) and little is known about the dynamics of the growth hormone secretion in this condition. It has been speculated that hypothalamopituitary disfunction underlies the endocrine manifestations of McCune-Albright's syndrome {Hall and Warrick 1972), and the endorgan autonomy (Danon, Robby, Kim, Scully and Crawford 1975) or a form of multiple endocrine adenomatosis {DiGeorge 1975) has also been suggested.…”

Acromegaly with Fibrous Dysplasia: McCune-Albright Syndrome-Clinical Studies in 3 Cases and Brief Review of Literature-

“…Till 2002, only 51 cases of MAS with acromegaly have been reported in English literature 34]. However, pathological examination of the pituitary either at surgery or necropsy has been reported in only 8 of them [3,6,7,10,14,24,28,30]. We report 3 patients, in the existing repertoire of this rare entity, who had fibrous dysplasia and acromegaly due to growth hormone (GH) secreting pituitary adenoma.…”

Acromegaly and Hyperthyroidism Associated with McCune-Albright Syndrome

“…His second endocrinologic abnor mality, acromegaly, is encountered rarely in McCuneAlbright syndrome. The few reported histologic studies in the adenohypophyses describe eosinophilic adenoma [8], multiloculated chromophobe adenoma [9] and mul tifocal acidophilic cell hyperplasia [10]. In this patient, neither tomography nor CT of the head could detect pituitary mass, suggesting that the hypersecretion of GH is caused by long-standing hypothalamic stimuli which may induce the release of GHRH rather than a rapidly growing pituitary tumor.…”