MCP‐1 and CCR2 gene variants in oral squamous cell carcinoma

Bektaş-Kayhan, Kıvanç; Ünür, Meral; Boy-Metin, Z; Çakmakoğlu, Bedia

doi:10.1111/j.1601-0825.2011.01843.x

Cited by 33 publications

(20 citation statements)

References 34 publications

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“…Degerli et al (2005) studied the CCR5-delta32 allele distribution and its relationship with breast, laryngeal, thyroid, and brain carcinomas in a Turkish population, which did not reveal any statistically significant relationships. In our previous studies, we found that the MCP-1 A2518G and CCR2-V64I genotypes were risk factors for endometrial (Attar et al, 2010), bladder (Narter et al, 2010), and oral cancer (Bektas-Kayhan et al, 2012). To the best of our knowledge, only two studies have investigated CCR5 variants with respect to the risk of oral cancer development.…”

Section: Discussionmentioning

confidence: 97%

“…Epidemiological studies have suggested that OSCC is a multifactorial disease that can be mediated by both environmental factors, such as alcohol and tobacco consumption, and genetic factors (Weng et al, 2010;Bektas-Kayhan et al, 2012). In parallel with these studies, we found that CCR5 59029 G+ genotypes (GG + AG), gender, smoking, alcohol consumption, and age were all associated with OSCC risk in univariate analyses; however, only CCR5 59029 G+ genotypes and alcohol consumption were associated with the disease in multivariate logistic regression analysis.…”

Section: Discussionmentioning

confidence: 99%

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Effects of genetic variants of CCR5 chemokine receptors on oral squamous cell carcinoma

Tanyel¹,

Çinçin²,

Röhlig³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. We aimed to evaluate the effect of genetic variants of the chemokine C-C motif receptor (CCR5) in the pathogenesis of oral squamous cell carcinoma (OSCC). A total of 127 patients diagnosed with OSCC and 104 healthy individuals were included in the study. The polymorphisms CCR5 59029 and CCR5-delta32 were assessed with the polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) method from peripheral blood samples of both groups. There was a statistically significant difference between the control and patient groups for CCR5 59029 A/G genotypes (P < 0.01). Individuals carrying the CCR5 59029 G allele (GG +AG genotypes) had a 2.84-fold increased risk for OSCC (P < 0.0001), and the CCR5 59029 AA genotype frequency was higher in the control group than in the patient group (P < 0.0001). The CCR5-delta 32 genotype frequencies did not differ significantly between controls and cases (P > 0.05). CCR5 59029 GG and CCR5- CCR5 gene in oral carcinoma delta32 DD + ID genotype frequencies were significantly increased in Grade II-III OSCC patients compared with Grade I-II OSCC patients. In conclusion, these results suggested that the G allele of the CCR5 59029 polymorphism might be a risk factor due to the loss of receptor function that might cause increased inflammation leading to the development of OSCC.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Effects of genetic variants of CCR5 chemokine receptors on oral squamous cell carcinoma

Tanyel¹,

Çinçin²,

Röhlig³

et al. 2013

Genet. Mol. Res.

View full text Add to dashboard Cite

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“…After HWE test, 3 articles (Saenz-Lopez et al, 2008;Attar et al, 2010;Gu et al, 2011) were deviated from HWE. Thus, a total of 11 case-control studies were extracted (VazquezLavista et al, 2009;Narter et al, 2010;Yang et al, 2010;Yeh et al, 2010;Chen et al, 2011;Kruszyna et al, 2011;Kucukgergin et al, 2012a;Kucukgergin et al, 2012b;Bektas-Kayhan et al, 2012;Singh et al, 2012;Wu et al, 2013). The characteristics of each case-control study are listed in Table 1.…”

Section: Study Inclusion and Characteristicsmentioning

confidence: 99%

The 2518 A/G Polymorphism in the MCP-1 Gene and Cancer Risk: A Meta-analysis

Jia

Shen²,

Guo³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Chemokine Receptors As Biomarkers In Head and Neck Squamous mentioning

confidence: 99%

“…Also, another group demonstrated that mutation of MCP-1 gene, which encodes CCR2 ligands, increased the expression of MCP-1 resulting in elevated CCR2 activity which could increase the risk for developing oral squamous carcinoma [23]. The authors predicted that MCP-1 and CCR2 could be used as genetic markers for diagnosis of oral carcinoma squamous [23].Another CC chemokine receptor, i.e., CCR7, which plays a critical role in the migration of activated dendritic cells to regional lymph nodes, was also found elevated in HNSCC tumor tissues compared with paraneoplastic tissues and the elevated expression of CCR7 was correlated with lymph metastasis and tumor tissue differentiation status [21]. Another study evaluated the expression of CCR7 in primary and metastatic tumor cell lines and biopsies from both primary and metastatic lesions, and it was found that CCR7 expression was elevated in metastatic cells and tissues [24].…”

mentioning

confidence: 99%

Chemokine Receptors as Biomarkers in Head and Neck Squamous Cell Carcinoma

Hou¹,

2013

J Oncobiomarkers

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Head and neck squamous cell carcinoma (HNSCC) is reported to be the 6th most common solid tumor diagnosed in the world [1]. Around 95% head and neck cancers are squamous cell carcinomas originating in the upper aerodigestive epithelial cells [2]. Despite continuous research efforts and progresses in diagnostic and therapeutic strategies, the mortality rates have not significantly changed over the past several decades [3]. Moreover, the five-year survival rate of HNSCC after diagnosis is considerably lower than that of other cancers, such as cervix, colorectal and breast cancer [4,5]. The reason for the limited five-year survival rate of HNSCC could be advanced disease stages, failure in early diagnosis and low efficiency of therapeutic strategies [6,7]. The death of HNSCC is mainly caused by invasion along with regional and/or distant metastatic spreading of tumor cells from primary tumor lesions [8]. Therefore, the key point of the treatment of head and neck cancers is early diagnosis.So far, numerous genes related to tumorigenesis and tumor progression have been identified and characterized. Some of them, such as c-myc, Ras, P53, P63, cyclin D1 etc., are expressed abnormally in head and neck cancers [3,[9][10][11]. Moreover, other aberrantly expressed proteins have also been found in head and neck carcinoma lesions, including PTEN [12,13], p27 [3,14], p21 [15] as well as annexins [16], which play significantly roles in the progression, malignancy and prognosis in head and neck carcinoma. These discoveries are helpful in early diagnosis of HNSCC.Meanwhile, the importance of chemokines and their cognate receptors in head and neck cancers is being revealed by increasing amount of studies. Recently, the expression of CXC chemokine receptor 2 (CXCR2) was reported substantially higher than that in paraneoplastic tissue in laryngeal squamous cell carcinoma [17]. The authors also found that the elevated expression was significantly related with lymph node metastasis, histological grade, and 5-year survival [17]. They concluded that CXCR2 expression could be considered as a potent prognostic marker for laryngeal squamous cell carcinoma patients [17].Several studies have also documented the significance of CXCR4 in HNSCC tumor progression and organ-specific metastasis [18,19]. Wang et al investigated the expression of CXCR4 in nasopharyngeal carcinoma tissues, and they found that CXCR4 expression was elevated in tumor tissues and the increased expression was correlated with metastatic rates in patients as well as poor overall survival [20]. This finding was consistent with another study which reported that CXCR4 mRNA was significantly higher in HNSCC tissues than in paraneoplastic tissues and its expression were associated with lymph node metastasis and distant metastasis [21]. These findings clearly demonstrate that CXCR4 could also be used to predict prognosis and metastasis in HNSCC patients.Chen et al. reported that a 64I mutation of the CC chemokine receptor-2 (CCR2) is significantly associated with oral cancer sus...

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MCP‐1 and CCR2 gene variants in oral squamous cell carcinoma

Abstract: We can suggest that the G allele of MCP-1 and 64I allele of CCR2 may be risk factors for OSCC.

Cited by 33 publications

References 34 publications

Effects of genetic variants of CCR5 chemokine receptors on oral squamous cell carcinoma

Effects of genetic variants of CCR5 chemokine receptors on oral squamous cell carcinoma

The 2518 A/G Polymorphism in the MCP-1 Gene and Cancer Risk: A Meta-analysis

Chemokine Receptors as Biomarkers in Head and Neck Squamous Cell Carcinoma

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