2011
DOI: 10.1186/1471-2156-12-34
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MCP1 haplotypes associated with protection from pulmonary tuberculosis

Abstract: BackgroundThe monocyte chemoattractant protein 1 (MCP-1) is involved in the recruitment of lymphocytes and monocytes and their migration to sites of injury and cellular immune reactions. In a Ghanaian tuberculosis (TB) case-control study group, associations of the MCP1 -362C and the MCP1 -2581G alleles with resistance to TB were recently described. The latter association was in contrast to genetic effects previously described in study groups originating from Mexico, Korea, Peru and Zambia. This inconsistency p… Show more

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Cited by 15 publications
(17 citation statements)
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“…Here, we discovered that BCG induces DCs to produce significantly higher concentrations of MCP-1 and RANTES than M. bovis. MCP-1 is known to be a T-lymphocyte chemoattractant (Shimizu et al, 2005), and MCP-1 gene variants are associated with susceptibility or protection against mycobacterial infection (Intemann et al, 2011). Similarly, RANTES plays an important role in mediating T-cell .…”
Section: Bovis Has a Stronger Ability Than Bcg To Induce Proinflammentioning
confidence: 99%
“…Here, we discovered that BCG induces DCs to produce significantly higher concentrations of MCP-1 and RANTES than M. bovis. MCP-1 is known to be a T-lymphocyte chemoattractant (Shimizu et al, 2005), and MCP-1 gene variants are associated with susceptibility or protection against mycobacterial infection (Intemann et al, 2011). Similarly, RANTES plays an important role in mediating T-cell .…”
Section: Bovis Has a Stronger Ability Than Bcg To Induce Proinflammentioning
confidence: 99%
“…Previous studies have variably demonstrated increased risk or protection from pulmonary tuberculosis associated with single SNP variants and/or different haplotypes created by promoter region SNPs at -362 bp and at -2,518 bp (Flores-Villanueva et al 2005, Thye et al 2009, Intemann et al 2011). One of these studies (Flores-Villanueva et al 2005) further showed that tuberculosis patients carrying the G allele for the SNP at -2,518 bp had the highest plasma levels of MCP-1 and the lowest plasma levels of IL-12p40, which was therefore interpreted as a secondary effect of MCP-1 in impairing the Th1 immune response against Mycobacterium tuberculosis .…”
mentioning
confidence: 99%
“…MCP-1 is involved in attracting monocytes to sites of inflammation and infection. In the Ghanaian study group, the MCP1 promoter allele −2581G (rs1024611) was significantly associated with resistance to tuberculosis [28,29]. In contrast, the same allele was associated in another study with susceptibility to clinical tuberculosis in a Korean and in an independent Mexican population [30], where both study groups were significantly smaller than was the Ghanaian group.…”
Section: Candidate Gene Studies In Tuberculosismentioning
confidence: 87%
“…In mycobacterial diseases, GWAS yielding genome-wide significant results have so far been conducted in tuberculosis and in leprosy [28][29][30][31]. In tuberculosis, more than 1300 cases and 1900 healthy controls from Ghana were analyzed on a genome-wide scale testing the 900 000 SNPs represented on the Affymetrix SNP array 6.0.…”
Section: Genome-wide Association Studiesmentioning
confidence: 99%