MCRT, a chimeric peptide based on morphiceptin and PFRTic-NH2, regulates the depressor effects induced by endokinin A/B

Zhang, Jing; He, Chunbo; Pi, Xiong; Wang, Yan; Zhou, Lei; Dong, Shouliang

doi:10.1016/j.ejphar.2016.10.028

Cited by 3 publications

(2 citation statements)

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“…MCRT (YPFPFRTic-NH 2 ), a chimeric heptapeptide based on morphiceptin (YPFP-NH 2 ) and a neuropeptide FF (NPFF) derivative (PFRTic-NH 2 ), was designed and synthesized via an overlapping proline. [1][2][3] Parent peptide morphiceptin, which was isolated from the enzymatic digest of bovine b-casein, showed the high selectivity for l-opioid receptor (MOR). [4] In-vitro contractility studies, morphiceptin at 10 À6 mol/l concentration completely blocked the neostigmine-induced colon contractions.…”

Section: Introductionmentioning

confidence: 99%

“…MCRT (YPFPFRTic‐NH 2 ), a chimeric heptapeptide based on morphiceptin (YPFP‐NH 2 ) and a neuropeptide FF (NPFF) derivative (PFRTic‐NH 2 ), was designed and synthesized via an overlapping proline . Parent peptide morphiceptin, which was isolated from the enzymatic digest of bovine β‐casein, showed the high selectivity for μ‐opioid receptor (MOR) .…”

Section: Introductionmentioning

confidence: 99%

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Supraspinal inhibitory effects of chimeric peptide MCRT on gastrointestinal motility in mice

Zhang

et al. 2017

Journal of Pharmacy and Pharmacology

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(1) Morphiceptin and PFRTic-NH played important roles in the regulation of gastrointestinal motility; (2) MCRT possessed higher bioactivity of pain relief than gastrointestinal regulation, suggesting its promising analgesic property; (3) MCRT-induced motility disorders were sensitive to DOR but not to MOR blockade, indicating the pain-relieving specificity of speculated MOR subtype or splice variant or MOR-DOR heterodimer.

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