MDL 73,404: A Cardioselective Antioxidant that Protects Against Myocardial Reperfusion Injury

Petty, Margaret A.

doi:10.1111/j.1527-3466.1992.tb00260.x

Cited by 6 publications

(2 citation statements)

References 34 publications

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“…C,H. 5-Acetoxy-2,3-dihydro-2,2,4,6,7-pentamethyl-l-benzofuran-3-carbonyl Chloride (11). To a solution of 9.59 g (0.047 mol) of trichloromethyl chloroformate in 80 mL of dry CH2C12 under N2 was added dropwise over 3 h a solution of 13.75 g (0.047 mol) of 10 and 4.77 g (0.047 mol) of NEt3 in 100 mL of CH2C12.…”

Section: Methodsmentioning

confidence: 99%

2,3-Dihydro-1-benzofuran-5-ols as Analogs of .alpha.-Tocopherol That Inhibit in Vitro and ex Vivo Lipid Autoxidation and Protect Mice against Central Nervous System Trauma

Jm¹,

Fn²,

Ma³

et al. 1995

J. Med. Chem.

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A series of alpha-tocopherol analogues was synthesized with potential therapeutic value for such pathological conditions as stroke and trauma. A set of criteria such as the inhibition of in vitro lipid peroxidation, superoxyl radical scavenging, and brain penetration, as measured by ex vivo inhibition of lipid peroxidation, was applied to select the most effective compound. 2,3-Dihydro-2,2,4,6,7-pentamethyl-3-[(4-methylpiperazino)methyl]-1 - benzofuran-5-ol dihydrochloride (22) was selected because of its superior antioxidant properties and better brain penetration. This compound also protected mice against the effects of head injury. The criteria thus turned out to be useful for the characterization of a neuroprotective analogue of alpha-tocopherol.

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Section: Methodsmentioning

confidence: 99%

2,3-Dihydro-1-benzofuran-5-ols as Analogs of .alpha.-Tocopherol That Inhibit in Vitro and ex Vivo Lipid Autoxidation and Protect Mice against Central Nervous System Trauma

Jm¹,

Fn²,

Ma³

et al. 1995

J. Med. Chem.

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show abstract

“…A water-soluble analogue, Trolox (7, Fig. (12)), which is also hydrophilic, to accumulate in heart tissue [58][59][60], reducing myocardial infarct size following reperfusion [61,62]. Then, Grisar and coworkers reported an analogue 62 ( Fig.…”

Section: Introductioinmentioning

confidence: 99%

Antioxidants Derived from Vitamin E: An Overview

Cerecetto

López²

2007

MRMC

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Alpha-tocopherol is a very well-known potent antioxidant and radical scavenger in chemical and biological systems. Its structure has served as starting point for design and synthesis of more potent antioxidant analogues with regard to its potential clinical and nutritional applications in human health. Furthermore, in recent years, intense research has been made not only in the development of hybrid compounds with classical drug moieties in a single molecule, but also in the preparation of label analogues with application in tocopherol metabolism studies. In the present review principal progresses in these aspects are outlined.

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Novel Synthetic Antioxidants and Nitrated Lipids: From Physiology to Therapeutic Implications

López

Rubbo

2010

Studies on Cardiovascular Disorders

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MDL 73,404: A Cardioselective Antioxidant that Protects Against Myocardial Reperfusion Injury

Cited by 6 publications

References 34 publications

2,3-Dihydro-1-benzofuran-5-ols as Analogs of .alpha.-Tocopherol That Inhibit in Vitro and ex Vivo Lipid Autoxidation and Protect Mice against Central Nervous System Trauma

2,3-Dihydro-1-benzofuran-5-ols as Analogs of .alpha.-Tocopherol That Inhibit in Vitro and ex Vivo Lipid Autoxidation and Protect Mice against Central Nervous System Trauma

Antioxidants Derived from Vitamin E: An Overview

Novel Synthetic Antioxidants and Nitrated Lipids: From Physiology to Therapeutic Implications

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